Irtopan tablets


  • Active Ingredient: Metoclopramide
  • 10 mg
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What is Irtopan?

The active ingredient of Irtopan brand is metoclopramide. Metoclopramide increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Used for

Irtopan is used to treat diseases such as: Gastroparesis, GERD, Lactation Augmentation, Migraine, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Radiographic Exam, Small Intestine Intubation.

Side Effect

Possible side effects of Irtopan include: difficulty with breathing; convulsions (seizures); mask-like face; loss in sexual ability, desire, drive, or performance; increase in blood pressure; clay colored stools; uncontrolled movements of the arms and legs; decreased interest in sexual intercourse.

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CNS Effects

Restlessness, drowsiness, fatigue, and lassitude occur in approximately 10% of patients receiving the most commonly prescribed dosage of 10 mg q.i.d. (see PRECAUTIONS). Insomnia, headache, confusion, dizziness, or mental depression with suicidal ideation (see WARNINGS) occur less frequently. The incidence of drowsiness is greater at higher doses. There are isolated reports of convulsive seizures without clear-cut relationship to Irtopan. Rarely, hallucinations have been reported.

Ondansetron (Zofran) vs. Irtopan (Reglan): What's the difference?

  • Ondansetron and Irtopan are used to prevent and treat nausea and vomiting.
  • Ondansetron is most often used to prevent nausea and vomiting caused by cancerchemotherapy and to prevent vomiting and nausea after surgery.
  • Irtopan is used to relieve heartburn symptoms with gastroesophageal reflux when certain other treatments do not work and to relieve the symptoms of slow stomach emptying in people with diabetes.
  • Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz.
  • Brand names for Irtopan include Reglan and Metozolv ODT.
  • Ondansetron and Irtopan belong to different drug classes. Ondansetron is an anti-nausea medication and Irtopan is a "prokinetic" drug.
  • Side effects of ondansetron and Irtopan that are similar include fatigue and drowsiness.
  • Side effects of ondansetron that are different from Irtopan include headache, feeling unwell (malaise), constipation, dizziness, diarrhea, and abnormal heart rate and rhythm.
  • Side effects of Irtopan that are different from ondansetron include restlessness, anxiety, insomnia, depression, and sedation.


Each white, capsule-shaped, scored reglan ® tablet (Irtopan tablets, USP) contains 10 mg Irtopan base (as the monohydrochloride monohydrate). Available in:

Bottles of 100 tablets (NDC 62559-166-01)

Each green, elliptical-shaped reglan ® tablet (Irtopan tablets, USP) contains 5 mg Irtopan base (as the monohydrochloride monohydrate). Available in:

Bottles of 100 tablets (NDC 62559-165-01)

Why it's used

Irtopan is used to treat gastroesophageal reflux disease (GERD) that causes symptoms. GERD occurs when acid flows up from your stomach. This causes heartburn. It may also harm your esophagus (the tube that connects your mouth to your stomach). This drug is used to relieve heartburn and heal sores in your esophagus when other treatments haven’t worked.

Irtopan is also used to treat diabetic gastroparesis. Gastroparesis happens when your stomach takes too long to empty its contents. Symptoms may include nausea, vomiting, heartburn, loss of appetite, and feeling full long after meals.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications to treat your condition.

Important Information

Do not use this medicine if you've ever had muscle movement problems after using Irtopan or similar medicines, or if you've had a movement disorder called tardive dyskinesia. You also should not use this medicine if you've had stomach or intestinal problems (a blockage, bleeding, or a hole or tear), epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).

NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use can cause a serious movement disorder that may not be reversible. The longer you use Irtopan, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).

Before you take Irtopan, tell your doctor if you have kidney or liver disease, congestive heart failure, high blood pressure, diabetes, Parkinson's disease, or a history of depression.

Do not drink alcohol. It can increase some of the side effects of Irtopan.

Stop using Irtopan and call your doctor at once if you have tremors or uncontrolled muscle movements, fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing, depressed mood, thoughts of suicide or hurting yourself, hallucinations, anxiety, agitation, seizure, or jaundice (yellowing of your skin or eyes).

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