Furobactina capsules

Furobactina

  • Active Ingredient: Nitrofurantoin
  • 50 mg
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What is Furobactina?

The active ingredient of Furobactina brand is nitrofurantoin. Nitrofurantoin is an antibiotic that fights bacteria in the body. Molecular Weight: 238.16 The chemical name of nitrofurantoin monohydrate is 1-[[[5-nitro-2-furanyl]methylene]amino]-2,4- imidazolidinedione monohydrate. The chemical structure is the following:

Used for

Furobactina is used to treat diseases such as: Bladder Infection, Prevention of Bladder infection, Urinary Tract Infection.

Side Effect

Possible side effects of Furobactina include: nausea or vomiting; loss of heat from the body; joint or muscle pain; drowsiness; confusion; diarrhea, watery and severe, which may also be bloody.

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Before taking Furobactina

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Furobactina it is important that your doctor knows:

  • If you are pregnant or breastfeeding. Although Furobactina can be taken during pregnancy, it is still important that you tell your doctor about being pregnant.
  • If you have any problems with the way your liver works, or if you have any problems with the way your k >

Respiratory

CHRONIC, SUBACUTE, OR ACUTE PULMONARY HYPERSENSITIVITY REACTIONS MAY OCCUR WITH THE USE OF NITROFURANTOIN.

CHRONIC PULMONARY REACTIONS GENERALLY OCCUR IN PATIENTS WHO HAVE RECEIVED CONTINUOUS TREATMENT FOR SIX MONTHS OR LONGER. MALAISE, DYSPNEA ON EXERTION, COUGH, AND ALTERED PULMONARY FUNCTION ARE COMMON MANIFESTATIONS WHICH CAN OCCUR INSIDIOUSLY. RADIOLOGIC AND HISTOLOGIC FINDINGS OF DIFFUSE INTERSTITIAL PNEUMONITIS OR FIBROSIS, OR BOTH, ARE ALSO COMMON MANIFESTATIONS OF THE CHRONIC PULMONARY REACTION. FEVER IS RARELY PROMINENT

THE SEVERITY OF CHRONIC PULMONARY REACTIONS AND THEIR DEGREE OF RESOLUTION APPEAR TO BE RELATED TO THE DURATION OF THERAPY AFTER THE FIRST CLINICAL SIGNS APPEAR. PULMONARY FUNCTION MAY BE IMPAIRED PERMANENTLY, EVEN AFTER CESSATION OF THERAPY. THE RISK IS GREATER WHEN CHRONIC PULMONARY REACTIONS ARE NOT RECOGNIZED EARLY.

In subacute pulmonary reactions, fever and eosinophilia occur less often than in the acute form. Upon cessation of therapy, recovery may require several months. If the symptoms are not recognized as being drug-related and Furobactina therapy is not stopped, the symptoms may become more severe.

Acute pulmonary reactions are commonly manifested by fever, chills, cough, chest pain, dyspnea, pulmonary infiltration with consolidation or pleural effusion on x-ray, and eosinophilia. Acute reactions usually occur within the first week of treatment and are reversible with cessation of therapy. Resolution often is dramatic. (See WARNINGS.)

Changes in EKG (e.g., non-specific ST/T wave changes, bundle branch block) have been reported in association with pulmonary reactions.

Cyanosis has been reported rarely.

Hepatic: Hepatic reactions, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. (See WARNINGS.)

Allergic: Lupus-like syndrome associated with pulmonary reaction to Furobactina has been reported. Also, angioedema; maculopapular, erythematous, or eczematous eruptions; anaphylaxis; arthralgia; myalgia; drug fever; chills; and vasculitis (sometimes associated with pulmonary reactions) have been reported. Hypersensitivity reactions represent the most frequent spontaneously-reported adverse events in worldwide postmarketing experience with Furobactina formulations.

Dermatologic: Exfoliative dermatitis and erythema multiforme (including Stevens-Johnson syndrome) have been reported rarely.

Hematologic: Cyanosis secondary to methemoglobinemia has been reported rarely.

Miscellaneous: As with other antimicrobial agents, superinfections caused by resistant organisms, e.g., Pseudomonas species or Candida species, can occur.

In clinical trials of Macrobid, the most frequent laboratory adverse events (1-5%), without regard to drug relationship, were as follows: eosinophilia, increased AST (SGOT), increased ALT (SGPT), decreased hemoglobin, increased serum phosphorus. The following laboratory adverse events also have been reported with the use of Furobactina: glucose-6- phosphate dehydrogenase deficiency anemia (see WARNINGS), agranulocytosis, leukopenia, granulocytopenia, hemolytic anemia, thrombocytopenia, megaloblastic anemia. In most cases, these hematologic abnormalities resolved following cessation of therapy. Aplastic anemia has been reported rarely.

Side Effects

Nausea, vomiting, loss of appetite, or headache may occur. Take this medication with food to help minimize nausea. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

This medication may cause your urine to turn dark yellow or brown in color. This effect is harmless and will disappear when the medication is stopped.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may rarely cause very serious (possibly fatal) lung problems. Lung problems may occur within the first month of treatment or after long-term use of Furobactina (generally for 6 months or longer). Get medical help right away if you develop symptoms of lung problems, including: persistent cough, chest pain, shortness of breath/trouble breathing, joint/muscle pain, bluish/purplish skin.

Tell your doctor right away if any of these rare but very serious side effects occur: new signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, mental/mood changes, persistent or severe headaches, vision changes.

This drug may rarely cause serious (possibly fatal) liver disease, blood or nerve problems. Tell your doctor right away if you notice any of the following rare but very serious side effects: persistent nausea/vomiting, dark urine, yellowing of eyes/skin, unusual/persistent fatigue, fast/pounding heartbeat, numbness/tingling of the arms/legs, muscle weakness.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea or opioid medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (e.g., oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Can Furobactina cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the ones associated with Furobactina. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Drugs you should not use with Furobactina

Do not take these drugs with Furobactina. Examples of these drugs include:

  • Antacids such as Gaviscon that contain magnesium trisilicate: These drugs can make Furobactina less effective.
  • Probenecid and sulfinpyrazone: Taking these drugs while you’re taking Furobactina may cause harmful levels of Furobactina to build up in your blood. High levels of this drug in your body raise your risk of side effects, while reduced levels in your urine can make the drug less effective.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Furobactina oral capsule comes with several warnings.

SIDE EFFECTS

In clinical trials of Macrobid, the most frequent clinical adverse events that were reported as possibly or probably drug-related were nausea (8%), headache (6%): and flatulence (1.5%). Additional clinical adverse events reported as possibly or probably drug-related occurred in less than 1% of patients studied and are listed below within each body system in order of decreasing frequency:

Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, emesis

Neurologic: Dizziness, drowsiness, amblyopia

Respiratory: Acute pulmonary hypersensitivity reaction (see WARNINGS)

Miscellaneous: Fever, chills, malaise

The following additional clinical adverse events have been reported with the use of Furobactina:

Gastrointestinal: Sialadenitis, pancreatitis. There have been sporadic reports of pseudomembranous colitis with the use of Furobactina. The onset of pseudomembranous colitis symptoms may occur during or after antimicrobial treatment. (See WARNINGS.)

Neurologic: Peripheral neuropathy, which may become severe or irreversible, has occurred. Fatalities have been reported. Conditions such as renal impairment (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine), anemia, diabetes mellitus, electrolyte imbalance, vitamin B deficiency, and debilitating diseases may increase the possibility of peripheral neuropathy. (See WARNINGS.)

Asthenia, vertigo, and nystagmus also have been reported with the use of Furobactina.

Benign intracranial hypertension (pseudotumor cerebri), confusion, depression, optic neuritis, and psychotic reactions have been reported rarely. Bulging fontanels, as a sign of benign intracranial hypertension in infants, have been reported rarely.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to Furobactina.

If you have diabetes, use Clinistix or Tes-Tape instead of Clinitest to test your urine for sugar. Furobactina can cause Clinitest to show false results.

Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the Furobactina, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Warnings for people with certain health conditions

For people with kidney disease: If you have a history of kidney disease, you may not be able to clear Furobactina from your body well. This could lead to a buildup of Furobactina. This raises your risk of side effects.

For people with liver disease: You should not use Furobactina. It can make your liver damage worse.

8. Cautions with other medicines

There are some medicines that don't mix well with Furobactina.

Tell your doctor if you're taking these medicines before you start Furobactina treatment:

  • indigestion remedies known as antacids, particularly those that contain magnesium
  • certain medicines for gout, including probenecid or sulfinpyrazone
  • cystitis remedies you can buy from a pharmacy
  • antibiotics known as quinolones, including nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin and moxifloxacin

Typhoid vaccine given by mouth may not work properly if you're taking Furobactina. This doesn't apply to typhoid vaccines given by injection.

Citrobacter ama/onaticus Citrobacter diversus Citrobacter freundii Klebsiella oxytoca Klebsiella ozaenae

Furobactina is not active against most strains of Proteus species or Serratia species. It has no activity against Pseudomonas species.

Recommendation

Furobactina can be given during pregnancy to treat urinary tract infections when the antibiotics of choice have been ineffective. If possible, it should be avoided towards the end of pregnancy. The use of nifuroxazide, nifurtimox, local nitrofurans, methenamine, and nitroxoline should be avoided during pregnancy.

When the antibiotics of choice in pregnancy cannot be used, fosfomycin tromethamine may be used to treat urinary tract infections in pregnancy. The intravenous application of fosfomycin should be restricted to severe bacterial infections with problematic germs.

On this page

  1. About Furobactina
  2. Key facts
  3. Who can and can't take Furobactina
  4. How and when to take it
  5. Side effects
  6. How to cope with side effects
  7. Pregnancy and breastfeeding
  8. Cautions with other medicines
  9. Common questions

Nursing Mothers

Furobactina has been detected in human breast milk in trace amounts. Because of the potential for serious adverse reactions from Furobactina in nursing infants under one month of age, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. (See CONTRAINDICATIONS.)

Before taking this medicine

You should not take Furobactina if you are allergic to it, or if you have:

severe kidney disease;

a history of jaundice or liver problems caused by taking Furobactina;

if you are urinating less than usual or not at all; or

if you are in the last 2 to 4 weeks of pregnancy.

Do not take Furobactina if you are in the last 2 to 4 weeks of pregnancy.

To make sure Furobactina is safe for you, tell your doctor if you have:

an electrolyte imbalance or vitamin B deficiency;

glucose-6-phosphate dehydrogenase (G6PD) deficiency; or

any type of debilitating disease.

FDA pregnancy category B. This medicine is not expected to be harmful to an unborn baby during early pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Furobactina side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Furobactina: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

diarrhea that is watery or bloody;

sudden chest pain or discomfort, wheezing, dry cough or hack;

new or worsening cough, trouble breathing;

fever, chills, body aches, tiredness, unexplained weight loss;

numbness, tingling, or pain in your hands or feet;

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

lupus-like syndrome--joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color.

Serious side effects may be more likely in older adults and those who are ill or debilitated.

Common Furobactina side effects may include:

gas, upset stomach;

mild diarrhea; or

vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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