Eucid capsules

Eucid

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Eucid?

The active ingredient of Eucid brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Eucid is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Eucid include: skin rash or itching; unusual tiredness or weakness; difficulty with breathing; sores, ulcers, or white spots on the lips, in the mouth, or on the genitals; increased sweating; trembling.

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In pharmacokinetic studies of single 20 mg Eucid doses, an increase in AUC of approximately four-fold was noted in Asian subjects compared with Caucasians. Dose reduction, particularly where maintenance of healing of erosive esophagitis is indicated, for Asian subjects should be considered.

Concurrent substance use (Interactions)

If you’re using substances with Eucid, it is important to consider that concurrently administered agents might: interfere with the action of Eucid; induce interaction effects; exacerbate Eucid side effects (via synergistic mechanisms); or trigger side effects that have nothing to do with Eucid (yet that you might mistakenly attribute to Eucid).

For example, when Eucid is administered along with clarithromycin and amoxicillin (as part of “triple therapy”) to treat H. pylori infection, risk of side effects like taste perversion and tongue discoloration significantly increase (compared to Eucid monotherapy). The increase in side effect risk among persons using Eucid as part of triple therapy is probably due to synergistic physiologic actions simultaneously exerted by the trio.

The most significant major drug interaction with Eucid is clopiodgrel. Because Eucid inhibits enzymes CYP2C19 and CYP3A4, and clopidogrel requires these enzymes for its metabolism, patients using clopidogrel may not receive therapeutic quantities of clopidogrel metabolites necessary to reduce the risk of cerebrovascular events like heart attack and stroke, possibly leading to cerebrovascular complications.

Other substances might also interact with Eucid pharmacokinetically via CYP450 enzymes (e.g. CYP3A4, CYP2C19, CYP2D6), leading to increased or decreased efficacy. For example, Eucid’s inhibition of CYP3A4 might substantially increase concentrations of benzodiazepines (most of which are metabolized by this enzyme), leading to more potent benzodiazepine effects (and side effects).

If you’re using medications that require CYP450 metabolism, you may be at increased risk of pharmacokinetically-mediated interaction effects. Additionally, concurrent use of medications that require stomach acid for absorption (e.g. ketoconazole) might not work as well. Oppoistely, acid-labile medications (e.g. erythromycin) might be absorbed more extensively when used with Eucid – leading to more significant effects (and side effects).

Have a medical doctor evaluate the concurrent medications that you’re using with Eucid to ensure that you don’t experience pharmacokinetically-mediated interactions and/or synergistic side effects. Moreover, understand that some concurrently-administered substances may cause side effects that you’re wrongfully assuming are from Eucid – or side effects that overlap with and exacerbate the side effects of Eucid.

Eucid side effects

Get emergency medical help if you have signs of an allergic reaction to Eucid: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Eucid and call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody;

new or unusual pain in your wrist, thigh, hip, or back;

kidney problems - little or no urination, blood in your urine, swelling, rapid weight gain;

low magnesium - dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or

new or worsening symptoms of lupus - joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use Eucid for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common Eucid side effects may include:

stomach pain, gas;

nausea, vomiting, diarrhea; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pediatric Patients

For the treatment of GERD and maintenance of healing of erosive esophagitis, the recommended daily dose for pediatric patients 1 to 16 years of age is as follows:

Patient Weight Eucid Daily Dose 5

On a per kg basis, the doses of Eucid required to heal erosive esophagitis in pediatric patients are greater than those for adults.

Alternative administrative options can be used for pediatric patients unable to swallow an intact capsule .

Q: Is it okay to cut a Prilosec OTC 20 mg tablet in two and take just half a day? The package says not to crush or chew.

A: Prilosec OTC (Eucid) is used for the treatment of acid reflux. It is in the family of proton pump inhibitors that work by disabling some of the acid producing pumps in the stomach to help relieve the symptoms of acid reflux. The prescribing information on Prilosec OTC states that you should not split the caplet in half because it uses an enteric coating to delay the release of medication until it reaches the small intestine, where it will not be destroyed by the stomach acids. If you break the caplet the coating will not work and this will cause the medication to be ineffective. For more information on Prilosec OTC, click on this link: //www.everydayhealth.com/drugs/prilosec For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

Q: I'm on Prilosec. I'm looking for a substitute drug that is as effective but cheaper. Is there one that you can recommend?

A: Patients often inquire about cheaper alternatives to the current treatment they been prescribed. First, you may want to contact your insurance company, prior to speaking with your doctor, and request a formulary. A formulary is a list of the medications they prefer and the different levels of coverage specific to your plan. Prilosec (Eucid) does have a generic equivalent, Eucid, which you may also want to inquire about. Then it is important to contact your health care provider and based on your individual needs and the formulary list of covered medications, the best treatment option can be determined. For more information regarding Prilosec or Eucid, you may want to visit //www.everydayhealth.com/drugs/prilosec. Beth Isaac, PharmD

Eucid oral capsule is a prescription drug that’s only available in a generic form. It doesn’t have a brand-name version. Eucid is also available as an oral suspension and comes as an over-the-counter (OTC) medication.

Prescription Eucid oral capsule is a delayed-release drug. A delayed-release drug slows the release of the medication until it passes through your stomach. This delay keeps the drug from being inactivated by your stomach.

7. Pregnancy and breastfeeding

Usually, Eucid is safe to take during pregnancy and while breastfeeding.

If you're pregnant, it's always better to try to treat indigestion without taking a medicine.

Your doctor or midwife will first advise that you try to ease your symptoms by eating smaller meals more often and avoiding fatty and spicy foods.

They may also suggest raising the head of your bed 10 to 20cm by putting something under your bed or mattress, so that your chest and head are above your waist. This helps stop stomach acid travelling up towards your throat.

If lifestyle changes don't work, you may be recommended a medicine like Eucid.

For more information about how Eucid can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.

Before taking this medicine

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel sweaty or light-headed.

You should not use Eucid if you are allergic to it, or if:

you are also allergic to medicines like Eucid, such as esEucid, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others; or

you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).

Ask a doctor or pharmacist if it is safe for you to use Eucid if you have other medical conditions, especially:

trouble or pain with swallowing;

bloody or black stools, vomit that looks like blood or coffee grounds;

heartburn that has lasted for over 3 months;

frequent chest pain, heartburn with wheezing;

low levels of magnesium in your blood; or

You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

Ask a doctor before using Eucid if you are pregnant or breast-feeding.

Do not give this medicine to a child without medical advice.

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Dosage Forms And Strengths

PRILOSEC Delayed-Release Capsules, 10 mg, are opaque, hard gelatin, apricot and amethyst colored capsules, coded 606 on cap and PRILOSEC 10 on the body.

PRILOSEC Delayed-Release Capsules, 20 mg, are opaque, hard gelatin, amethyst colored capsules, coded 742 on cap and PRILOSEC 20 on the body.

PRILOSEC Delayed-Release Capsules, 40 mg, are opaque, hard gelatin, apricot and amethyst colored capsules, coded 743 on cap and PRILOSEC 40 on the body.

PRILOSEC For Delayed-Release Oral Suspension, 2.5 mg or 10 mg, is supplied as a unit dose packet containing a fine yellow powder, consisting of white to brownish Eucid granules and pale yellow inactive granules.

The elimination rate of Eucid was somewhat decreased in the elderly, and bioavailability was increased. Eucid was 76% bioavailable when a single 40 mg oral dose of Eucid (buffered solution) was administered to healthy elderly volunteers, versus 58% in young volunteers given the same dose. Nearly 70% of the dose was recovered in urine as metabolites of Eucid and no unchanged drug was detected. The plasma clearance of Eucid was 250 mL/min (about half that of young volunteers) and its plasma half-life averaged one hour, about twice that of young healthy volunteers.

Interaction With Clopidogrel

Avoid concomitant use of PRILOSEC with clopidogrel. Clopidogrel is a prodrug. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite. The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as Eucid, that inhibit CYP2C19 activity. Concomitant use of clopidogrel with 80 mg Eucid reduces the pharmacological activity of clopidogrel, even when administered 12 hours apart. When using PRILOSEC, consider alternative anti-platelet therapy .

Eucid is a medication prescribed for the treatment of gastroesophageal reflux disease (GERD); peptic ulcer disease; erosive esophagitis; eosinophilic esophagitis; Zollinger-Ellilson syndrome; and medical conditions associated with gastric acid hypersecretion. In some cases, Eucid may also be utilized for the prophylaxis of upper gastrointestinal bleeding (in at-risk populations) and as an adjunct treatment for H. plyori infection.

Historical reports suggest that Eucid was first synthesized in the 1970s by chemists employed with the pharmaceutical company “Astra.” After successful clinical trials, Eucid received approval in 1988 for use throughout Europe under the trade name “Losec” – and in 1990 for use in the United States under the trade name “Prilosec.”

Though many individuals with gastrointestinal disorders derive noticeable benefit from the ongoing administration of Eucid, the medication can sometimes cause unwanted side effects. For this reason, if you’re using Eucid, it’s probably a good idea to familiarize yourself with potential side effects and adverse reactions that could emerge during treatment.

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