Espaven syrup


  • Active Ingredient: Ranitidine
  • 300 mg, 150 mg
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What is Espaven?

The active ingredient of Espaven brand is ranitidine. Ranitidine is in a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces. The empirical formula is C13H22N4O3S.HCl, representing a molecular weight of 350.87. Ranitidine HCl USP is a white to pale yellow crystalline powder that is soluble in water. It has a slightly bitter taste and sulfur-like odor. Each Ranitidine tablets, USP 150 mg for oral administration contains 168 mg of Ranitidine HCl USP equivalent to 150 mg of Ranitidine. Each tablet also contains the inactive ingredients magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hypromellose, titanium dioxide, triacetin, and iron oxide red. Each Ranitidine tablets, USP 300 mg for oral administration contains 336 mg of Ranitidine HCl USP equivalent to 300 mg of Ranitidine. Each tablet also contains the inactive ingredients magnesium stearate, microcrystalline cellulose, croscarmellose sodium, silicon dioxide, hypromellose, titanium dioxide, triacetin, and iron oxide red.

Used for

Espaven is used to treat diseases such as: Cutaneous Mastocytosis, Duodenal Ulcer, Duodenal Ulcer Prophylaxis, Eczema, Erosive Esophagitis, Gastric Ulcer Maintenance Treatment, Gastrointestinal Hemorrhage, GERD, Indigestion, Pathological Hypersecretory Conditions, Stomach Ulcer, Stress Ulcer Prophylaxis, Surgical Prophylaxis, Urticaria, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Espaven include: ; ; ; ; .

How to Buy Espaven capsules online?

To get Espaven online - simply click on the "Buy Now" button from the top and follow on to our store. Payment and Order takes a few minutes, and all steps are evident. We don't require a medical prescription plus also we have many procedures of payment. With all the details of fast delivery and confidentiality, then you may read on the applicable pages on the hyperlinks from the top menu.

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What other drugs will affect Espaven?

Before taking Espaven, tell your doctor if you are taking triazolam (Halcion). You may not be able to use this medicine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs that can interact with Espaven. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Why it’s used

Espaven oral tablet is used to treat several conditions, including:

Espaven may be used as part of a combination therapy. This means you may need to take it with other medications.

Espaven is typically used for short-term treatment, especially for GERD. If you’re taking this drug for other conditions, you may need long-term treatment. You may need to take it for several weeks or months.

What to do about:

  • stomach pains - try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you are in a lot of pain, speak to your pharmacist or doctor.
  • constipation - eat more high-fibre foods such as fresh fruit and vegetables and cereals, and drink plenty of water. Try to exercise, for example, by going for a daily walk or run. If this doesn't help, talk to your pharmacist or doctor.
  • feeling sick - it may help if you don't eat rich or spicy food while you're taking Espaven.

What Are Warnings and Precautions for Espaven?

  • Symptom relieve does not rule out presence of gastric malignancy
  • This medication contains Espaven. Do not take Zantac, Zantac 150 Maximum Strength, or Zantac 75 if you are allergic to Espaven or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

  • Hypersensitivity to Espaven or components of the formulation

Effects of Drug Abuse

  • Symptom relieve does not rule out presence of gastric malignancy
  • See also "What Are Side Effects Associated with Using Espaven?”

  • Prolonged treatment may lead to B12malabsorption and subsequent vitamin B12 deficiency; degree of deficiency is dose-related and association stronger in females and younger in age (younger than 30 years)
  • See also "What Are Side Effects Associated with Using Espaven?”

  • If gastroesophageal reflux disease does not respond adequately in 6-8 weeks, do not increase dosage; prescribe proton pump inhibitor instead
  • Prolonged treatment may lead to B12 malabsorption and subsequent vitamin B12 deficiency; degree of deficiency is dose-related and association stronger in females and younger in age (younger than 30 years)
  • Use caution in renal impairment; adjust dosage
  • Use caution in hepatic impairment
  • Elevation of ALT levels reported with higher doses (greater than 100 mg) or prolonged IV therapy (longer than 5 days); monitor for ALT levels for the remainder of treatment
  • Avoid in patients with acuteporphyria; may precipitate attack
  • Symptom relieve does not rule out presence of gastric malignancy
  • Reversible state of confusion reported with use (linked to age over 50 years and renal or hepatic impairment); clears within 3-4 days after discontinuation

  • Use of Espaven in pregnancy may be acceptable
  • Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk
  • Espaven transfers into breast milk
  • Discontinue use of Espaven if lactating and use caution

What are the possible s >

Stop using Espaven and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Espaven and call your doctor at once if you have a serious side effect such as:

  • chest pain, fever, feeling short of breath, coughing up green or yellow mucus;
  • easy bruising or bleeding, unusual weakness;
  • fast or slow heart rate;
  • problems with your vision;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • headache (may be severe);
  • drowsiness, dizziness;
  • sleep problems (insomnia);
  • decreased sex drive, impotence, or difficulty having an orgasm; or
  • swollen or tender breasts (in men);
  • nausea, vomiting, stomach pain; or
  • diarrhea or constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I take Espaven?

Take exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor's directions about the type of antacid to use, and when to use it.

Do not crush, chew, or break the Espaven effervescent tablet, and do not allow it to dissolve on your tongue. The 25-milligram effervescent tablet must be dissolved in at least 1 teaspoon of water before swallowing. The150-milligram effervescent tablet should be dissolved in 6 to 8 ounces of water.

Allow the Espaven effervescent tablet to dissolve completely in the water, and then drink the entire mixture. If you are giving this medicine to a child, you may draw the liquid mixture into a medicine dropper and empty the dropper into the child's mouth.

Espaven granules should be mixed with 6 to 8 ounces of water before drinking.

Measure Espaven liquid with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

It may take up to 8 weeks before your ulcer heals. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 6 weeks of treatment.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Espaven.

Store at room temperature away from moisture, heat, and light.


GENERIC NAME(S): Espaven Hcl

Espaven is used to treat ulcers of the stomach and intestines and prevent them from coming back after they have healed. This medication is also used to treat certain stomach and throat (esophagus) problems (such as erosive esophagitis, gastroesophageal reflux disease-GERD, Zollinger-Ellison syndrome). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Espaven belongs to a class of drugs known as H2 blockers.

This medication is also available without a prescription. It is used to prevent and treat heartburn and other symptoms caused by too much acid in the stomach (acid indigestion). If you are taking this medication for self-treatment, it is important to read the manufacturer's package instructions carefully so you know when to consult your doctor or pharmacist.

Q. How long has NDMA been present in Espaven?

A. FDA does not have enough scientific evidence yet to determine how long NDMA has been present in Espaven. The agency is continuing to investigate and will communicate more information as it is available.

Q. Should I stop taking Espaven?

A. FDA does not have scientific evidence to recommend whether individuals should continue or stop taking Espaven medicines at this time, but our testing of Espaven samples so far has shown levels of NDMA similar to the levels in common foods like grilled and smoked meats. There are multiple drugs that are approved for the same or similar uses as Espaven. Patients taking prescription Espaven who wish to discontinue use should talk to their health care professional about other treatment options. People taking OTC Espaven may consider using other OTC products approved for their condition.

If you are taking one of the recalled medicines, you should follow the recall instructions provided by the company. This information is on FDA’s website.

Q. Are other H2 blockers and other drugs for stomach acid conditions impacted by the impurity? Are there safe alternatives to Espaven?

A. FDA’s testing has not found NDMA in Pepcid (famotidine), Tagamet (cimetidine), Nexium (esomeprazole), Prevacid (lansoprazole) and Prilosec (omeprazole) at this time. In addition, assessment of their manufacturing processes indicates these medicines should not contain NDMA. FDA continues to test and assess other H2 blockers and proton pump inhibitors (PPIs) that could be used as alternatives to Espaven.

What is Espaven?

Espaven is in a group of drugs called histamine-2 blockers. Espaven works by reducing the amount of acid your stomach produces.

Espaven is used to treat and prevent ulcers in the stomach and intestines. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Espaven also treats gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

Espaven may also be used for purposes not listed in this medication guide.

Before using Espaven

Do not use this medication if you are allergic to Espaven.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

liver disease; or

porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Espaven is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Espaven passes into breast milk. Do not take this medicine without telling your doctor if you are breast-feeding a baby.

Using this medicine may increase your risk of developing pneumonia. Symptoms of pneumonia include chest pain, fever, feeling short of breath, and coughing up green or yellow mucus. Talk with your doctor about your specific risk of developing pneumonia.

The effervescent tablet may contain phenylalanine. Talk to your doctor before using the effervescent tablets if you have phenylketonuria (PKU).


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Zantac 75 (Espaven)." Pfizer U.S. Pharmaceuticals, New York, NY.

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Zantac (Espaven)." Glaxo Wellcome, Research Triangle Park, NC.


Espaven (Zantac) is a drug used for the treatment and prevention of stomach and duodenum ulcers. It is also used to treat heartburn, inflammation of the esophagus, and Zollinger-Ellison syndrome. Review side effects, drug interactions, dosage, and pregnancy safety information prior to taking any medication.

Q: Is Zantac okay to take in late pregnancy? I'm 32 weeks pregnant and can't live without them. I'm taking about 2 per day.

A: For stomach acid during pregnancy, Zantac (Espaven) is a category "B." In pregnancy, there are only 1 or 2 "perfect" drugs that are category "A," so if you need medication, you will probably be prescribed drugs that are in categories "B" or "C." The drugs that should be avoided are in catagories "D" and "X" because they can cause harmful effects. However, you should always consult with your doctor before taking any medication. You can also find helpful information on pregnancy at Patti Brown, PharmD

Drugs you should not use with Espaven

Delavirdine: Do not take delavirdine with Espaven. Doing so can cause dangerous effects. Espaven reduces the levels of delavirdine in your body. This means delavirdine won’t work as well.

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