• Active Ingredient: Esomeprazole
  • 40 mg, 20 mg
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What is Esopral?

The active ingredient of Esopral brand is esomeprazole. Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Used for

Esopral is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer Prophylaxis, Erosive Esophagitis, Gastric Ulcer Prophylaxis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, NSAID-Induced Gastric Ulcer, Pathological Hypersecretory Conditions, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Esopral include: Bad, unusual, or unpleasant (after) taste; Acne; pains in the stomach, side, or abdomen, possibly radiating to the back; intravenous powder for solution; difficulty with swallowing; drowsiness; unusual tiredness or weakness.

How to Buy Esopral online?

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What is Esopral, and how does it work (mechanism of action)?

Esopral is in a class of drugs called proton pump inhibitors (PPIs) which block the production of acid by the stomach. Other drugs in the same class include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex) and pantoprazole (Protonix). Chemically, Esopral is very similar to omeprazole. Proton pump inhibitors are used for the treatment of conditions such as stomach and duodenal ulcers, gastroesophageal reflux disease (GERD) and the Zollinger-Ellison syndrome which all are caused by stomach acid. Esopral, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. Esopral was approved by the FDA in February 2001.

  • K >Magnesium vs. strontium vs. sodiumThere are three types of Esopral: Esopral magnesium, Esopral strontium, and Esopral sodium. (This article is about Esopral magnesium.) They’re all Esopral, but they contain different salt forms. The different salt forms enable Esopral to be used to treat gastrointestinal issues in a range of people with different health needs.

Esopral is a prescription drug. Some forms are also available over the counter, but this article covers the prescription version only.

Esopral magnesium and Esopral strontium come as delayed-release capsules. Esopral magnesium also comes as a liquid suspension. Esopral sodium comes in an intravenous (IV) form, which is only given by a healthcare provider.

Esopral magnesium is available as the brand-name drug Nexium and as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug.

Esopral magnesium may be used as part of a combination therapy. This means you may need to take it with other medications, especially to treat H. pylori.

What is Esopral?

Esopral is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Esopral is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. Esopral is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Esopral may also be given to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Esopral is not for immediate relief of heartburn symptoms.

Esopral may also be used for purposes not listed in this medication guide.

Do I need a prescription for Esopral?

  • Yes - Nexium, Nexium IV
  • No - Nexium 24 hour

How should I take Esopral?

Use exactly as directed on the label, or as prescribed by your doctor.

Esopral is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.

Take each dose with a full glass (8 ounces) of water.

Esopral should be taken at least one hour before a meal.

Swallow the capsule whole and do not crush, chew, break, or open it.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

The Esopral capsule can be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Esopral.

Some conditions are treated with a combination of Esopral and antibiotics. Use all medications as directed.

Store at room temperature away from moisture and heat.

Risk Reduction Of Rebleeding Of Gastric Or Duodenal Ulcers Following Therapeutic Endoscopy In Adults

Adult dose is 80 mg administered as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg/h for a total treatment duration of 72 hours (i.e., includes initial 30-minute dose plus 71.5 hours of continuous infusion). Intravenous therapy is aimed solely at the acute initial management of bleeding gastric or duodenal ulcers and does not constitute full treatment. Intravenous therapy should be followed by oral acid-suppressive therapy. For patients with liver impairment, no dosage adjustment of the initial Esopral 80 mg infusion is necessary. For patients with mild to moderate liver impairment (Child-Pugh Classes A and B), a maximum continuous infusion of Esopral 6 mg/h should not be exceeded. For patients with severe liver impairment (Child-Pugh Class C), a maximum continuous infusion of 4 mg/h should not be exceeded .

Q: Are there any adverse effects from taking Nexium long-term?

A: Nexium (Esopral) is classified as a proton pump inhibitor and a substituted benzimidazole medication. Nexium works in the body to decrease the amount of acid produced by the stomach. Nexium is approved for the treatment of erosive esophagitis, GERD (gastroesophageal reflux disease), Helicobacter pylori (along with other medications), and in hypersecretory conditions including Zollinger-Ellison syndrome. Nexium, like any other medication, has possible side effects, risks, and warnings associated with its use. An alert was announced in in May 2010 about a possible increased risk of fractures of the hip, wrist, and spine associated with the proton pump inhibitor class of medications. The U.S. Food and Drug Administration (FDA) is in the process of revising the labeling for this class of medications and the risk of fractures. The greatest risk to patients were for those using the medication in high doses or taking the medication for longer than a year. According to medical references, the most common side effect of Nexium (occurring in greater than 10 percent of studied patients) is headache. Other common side effects include diarrhea, abdominal pain, and nausea. This is not a complete listing of all the associated side effects, risks, or warnings associated with the use of Nexium. According to the prescribing information, Nexium has been studied in both short-term and long-term studies. Long-term studies examined patients taking the medication for 6 to 12 months. In general, Nexium was said to be well tolerated in both the short-term and long-term clinical trials. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jen Marsico, RPh

Q: If you are taking Nexium, can you stop at any time?

A: Your question regards if you can stop taking Nexium (Esopral) // at any time. It is recommended to talk to your health care provider before stopping any prescription medication. If you do stop taking your medication, you may start to see symptoms returning of the condition that you initially were using it to treat (i.e. GERD). As always, talk with your health care provider regarding questions about your medications. Jen Marsico, RPh

Q: Can Nexium cause aches and pains after long term use?

A: Nexium (Esopral) belongs to a class of medications called Proton-Pump Inhibitors. Nexium decreases the amount of acid that is in the stomach and relieves heartburn that is caused by backflow of the stomach acid from the stomach to the esophagus. Nexium is indicated for the treatment of GERD or gastroesophageal reflux disease. Nexium is also used for a condition called Zollinger-Ellison syndrome. Nexium can be used to heal damage done to the esophagus from stomach acid and prevent gastric ulcers that are caused by certain bacteria. Nexium may be prescribed with certain antibiotics to treat bacteria called H Pylori. Ulcers may also develop from the use of Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Advil, Motrin (ibuprofen) and Aleve (naproxen). Nexium should be taken exactly as prescribed by the doctor. Nexium is a delayed release capsule or it should never be crushed or chewed to provide maximum benefit. Nexium can be opened and put with applesauce if the capsules cannot be swallowed. Nexium is usually taken at least one hour before food generally in the morning with a full glass of water. Unfortunately, Nexium will not provide immediate relief of heartburn symptoms. Nexium may take a few days to provide relief from symptoms of GERD. Common side effects associated with Nexium include dizziness, headache, diarrhea, constipation and dry mouth. Other less common side effects occurring in less than 1% of patients treated with Nexium include muscle pain, rash, back pain, chest pain, malaise or feeling "out of sorts" and flu-like symptoms. This is not a complete list of the side effects associated with Nexium. Kimberly Hotz, PharmD

Will my dose go up or down?

Sometimes your doctor will increase your dose if it isn't working well enough.

Depending on the reason you take Esopral, you may take a higher dose to begin with, usually for a month or two. After this, your doctor may recommend that you take a lower dose.

Serious Side Effects of Nexium (Esopral)

Stop using Nexium immediately and call your healthcare provider if you experience:

  • Confusion
  • Uneven heart rate
  • Jerking muscle movements
  • Muscle weakness and limp feeling
  • Convulsions
  • Severe allergic reaction (swelling of face, lips, throat, hives, difficulty breathing)
  • Hoarseness or trouble swallowing

Q: I'm taking Nexium 40 mg once daily. Could this cause me to gain wieght? I also feel tired since I have been on this medication. Is it causing the fatigue?

A: Nexium (Esopral) is a proton pump inhibitor (PPI) used for the treatment of esophageal reflux disease (GERD), gastric ulcers and other conditions. According to Lexi-Comp, insomnia was reported in 2% of patients during clinical trials. Less than 1% of patients reported somnolence (drowsiness) or weight changes during clinical trials. Your health care provider may be able to provide more information. Please see the following Everyday Health link for more information on Nexium (Esopral). // Laura Cable, PharmD

What if I take too much?

It is very unlikely that taking one or two extra doses by accident will cause any problems. However, you should check with your doctor if you have taken too much and have any of these symptoms:

  • feeling sweaty
  • a fast heartbeat
  • feeling sleepy
  • blurred vision
  • feeling confused or agitated

Most people who take Esopral do not have any side effects. If you do get a side effect, it is usually mild and will go away when you stop taking Esopral.

Q: Is there a generic for Nexium 40mg?

A: Nexium (Esopral) is in a drug class called proton pump inhibitors. Nexium is used to treat gastroesophageal reflux disease (GERD). Nexium is also used to prevent ulcers (sores in the lining of the stomach) in people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). In combination with certain other medications, Nexium is used to treat and prevent the recurrence of stomach ulcers caused by H. pylori, a type of bacteria. Nexium is also used to treat conditions (e.g., Zollinger-Ellison Syndrome) in which the stomach makes too much acid. Nexium works be reducing acid production in the stomach. Generic drugs are lower-cost alternatives to more expensive brand-name drugs. They will appear different and have a few other minor differences from the brand-name drugs, but their labeling and directions for use must be virtually the same as that of the brand name product. Both brand-name and generic drug manufacturing facilities must follow the same standards of good manufacturing practices and meet the U.S. Food and Drug Administration's (FDA) specifications. The FDA also requires that generic drugs be bioequivalent to their brand-name counterparts. This means that a generic drug will work the same way in your body as the brand-name medication. Generics are considered by the FDA to be identical to brand-name drugs in dose, strength, route of administration, safety, efficacy, and intended use. Currently there is not a generic version of Nexium available. The price of a medication, like Nexium, can vary depending on the wholesaler and pharmacy from which the medication is acquired. Pharmacies sell medication to consumers at a price that includes the cost for acquiring the drug from the wholesaler, plus a retail markup. If a third-party payer (for example, a health insurance company or Medicare) is providing coverage for a medication, such as Nexium, they determine the final cost of the product. Costs will vary from one plan to another, and the payer may cover or reimburse part or all of the cost. In addition to Nexium, Aciphex (rabeprazole), Kapidex (dexlansoprazole), Nexium (Esopral), Prevacid (lansoprazole), Prilosec (omeprazole), and Protonix (pantoprazole) belong to the proton pump inhibitor drug class. Studies show that, in general, proton pump inhibitors are about equally effective. Moreover, in general, there is little scientific evidence that there are any important differences in the safety of the proton pump inhibitors. As such, many third-party payers promote


Esopral (Nexium, Nexium 24HR, Nexium IV) is a proton pump inhibitor prescribed for the treatment of gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and for the treatment of H. pylori in combination with antibiotics. Side effects, dosing, warnings and precautions, and pregnancy safety should be reviewed prior to taking any medication.

Q: Are there risks with long-term use of Nexium?

A: Nexium (Esopral) belongs to a class of drugs called proton pump inhibitors. PPIs decrease the amount of acid produced by the stomach. They are used to treat the symptoms of gastro-esophageal reflux disease (GERD), to heal erosive esophagitis, and to treat or prevent ulcers. PPIs have been around for over 20 years and have good safety record, even with long-term use. However, there are some precautions to consider. The major long-term side effects of PPIs is a vitamin B12 deficiency, and more rarely an iron deficiency. In addition to blocking the acid pumps in the stomach, PPIs also block the production of a protein in the stomach called intrinsic factor. Intrinsic factor is necessary for the proper absorption of vitamin B12. So, over many years, a deficiency may develop. This can be treated with vitamin B12 supplements, if advised by your doctor. Another risk with long-term use is a possible increased risk of fractures of the hip, wrist, and spine. Studies are not clear at this point about whether PPIs actually cause the increased risk or if it is due to some other factor. For now, tell your doctor if you develop any new bone pain. Your doctor is best able to guide your treatment decisions. Sarah Lewis, PharmD

How it works

Esopral magnesium belongs to a class of drugs called proton pump inhibitors. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Esopral decreases the amount of acid your stomach produces. It works by blocking the proton pump in the stomach’s cells. When the proton pump is blocked, your stomach makes less acid.

Esopral magnesium oral capsule doesn’t cause drowsiness, but it can cause other side effects.

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