• Active Ingredient: Esomeprazole
  • 40 mg, 20 mg
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What is Esomep?

The active ingredient of Esomep brand is esomeprazole. Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Used for

Esomep is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer Prophylaxis, Erosive Esophagitis, Gastric Ulcer Prophylaxis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, NSAID-Induced Gastric Ulcer, Pathological Hypersecretory Conditions, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Esomep include: nausea; intravenous powder for solution; fever; cough; Bad, unusual, or unpleasant (after) taste; dizziness; constipation.

How to Buy Esomep online?

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What other drugs will affect Esomep?

Tell your doctor about all your current medicines. Many drugs can affect Esomep, especially:

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of NEXIUM. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing Reports - There have been spontaneous reports of adverse events with postmarketing use of Esomep. These reports occurred rarely and are listed below by body system:

Blood And Lymphatic System Disorders: agranulocytosis, pancytopenia; Eye Disorders: blurred vision; Gastrointestinal Disorders: pancreatitis; stomatitis; microscopic colitis; fundic gland polyps; Hepatobiliary Disorders: hepatic failure, hepatitis with or without jaundice; Immune System Disorders: anaphylactic reaction/shock; systemic lupus erythematosus; Infections and Infestations: GI candidiasis; Metabolism and nutritional disorders: hypomagnesemia with or without hypocalcemia and/or hypokalemia; Musculoskeletal And Connective Tissue Disorders: muscular weakness, myalgia, bone fracture; Nervous System Disorders: hepatic encephalopathy, taste disturbance; Psychiatric Disorders: aggression, agitation, depression, hallucination; Renal and Urinary Disorders: interstitial nephritis; Reproductive System and Breast Disorders: gynecomastia; Respiratory, Thoracic and Mediastinal Disorders: bronchospasm; Skin and Subcutaneous Tissue Disorders: alopecia, erythema multiforme, hyperhidrosis, photosensitivity, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN, some fatal), cutaneous lupus erythematosus.

Other adverse events not observed with NEXIUM, but occurring with omeprazole can be found in the omeprazole package insert, ADVERSE REACTIONS section.

7. Pregnancy and breastfeeding

Esomep isn't usually recommended during pregnancy as there's no firm evidence it's safe.

A medicine called omeprazole, which is similar to Esomep, is safe in pregnancy.

However, if you're pregnant, it's always better to try to treat your symptoms without taking a medicine.

Your doctor or midwife may suggest eating smaller meals more often and avoiding fatty and spicy food.

They may also suggest raising the head of your bed 10 to 20cm by putting something under your bed or mattress, so that your chest and head are above your waist. This helps stop stomach acid travelling up towards your throat.

If these lifestyle changes don't work, you may be recommended omeprazole to help ease your symptoms.

Q: Is Nexium safe to take during pregnancy?

A: Nexium (Esomep) is listed by the FDA as FDA pregnancy category B. Category B means that animal studies show no risk or adverse fetal effects, but controlled human first trimester studies are not available. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Nexium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breastfeeding a baby

Q: What is Nexium, and what are its side effects?

A: Nexium (Esomep), one of a group of drugs called proton pump inhibitors, decreases the amount of acid produced in the stomach. Nexium is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome, and is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). Nexium may also be given to prevent gastric ulcer caused by infection with helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Nexium is not for immediate relief of heartburn symptoms. The most common side effects with Nexium are headache, dizziness, rash, diarrhea, nausea/vomiting, and altered taste sensation. Less frequent, sever side effects include pancreatitis and hepatitis. This is not a complete list of the side effects associated with Nexium. Gregory Latham, RPh

Q: I'm taking Nexium 40 mg once daily. Could this cause me to gain wieght? I also feel tired since I have been on this medication. Is it causing the fatigue?

A: Nexium (Esomep) is a proton pump inhibitor (PPI) used for the treatment of esophageal reflux disease (GERD), gastric ulcers and other conditions. According to Lexi-Comp, insomnia was reported in 2% of patients during clinical trials. Less than 1% of patients reported somnolence (drowsiness) or weight changes during clinical trials. Your health care provider may be able to provide more information. Please see the following Everyday Health link for more information on Nexium (Esomep). // Laura Cable, PharmD

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Esomep.

Q: I have acid reflux and hiatus hernia. Should I be taking Nexium, even though I am not bothered with problems?

A: The decision on whether or not you need to be on a medication should be made by your health care provider. There are many variables in this decision. If you are currently taking Nexium (Esomep) (// you may not be having symptoms because the medication is working for you. As always, talk with your health care provider regarding questions you have about your medication. The following link will take you to information provided by Everyday Health regarding acid reflux or GERD: // Jen Marsico, RPh

How should I take Esomep?

Use exactly as directed on the label, or as prescribed by your doctor.

Take each dose with a full glass (8 ounces) of water.

Esomep should be taken at least one hour before a meal.

Swallow the pill whole and do not crush, chew, break, or open it.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

The Esomep capsule can be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Esomep is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.

Use Esomep for the full prescribed length of time, even if your symptoms quickly improve.

Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Esomep.

Some conditions are treated with a combination of Esomep and antibiotics. Use all medications as directed.

Store at room temperature away from moisture and heat.

8. Cautions with other medicines

Some medicines can interfere with Esomep and make you more likely to have side effects.

Tell your doctor if you're taking these medicines before you start taking Esomep:

  • digoxin (a heart medicine)
  • cilostazol (a medicine used to treat painful legs caused by poor circulation)
  • antifungal medicines such as itraconazole, ketoconazole or posaconazole
  • methotrexate (a medicine used to treat cancer and conditions like psoriasis and rheumatoid arthritis)
  • HIV medicines
  • phenytoin (an anti-epilepsy medicine)
  • rifampicin (an antibiotic)
  • blood thinning medicines, such as clopidogrel
  • citalopram, escitalopram, clomipramine or imipramine (antidepressants)
  • tacrolimus (a medicine used for eczema or to prevent organ rejection after a transplant)

These are not all the medicines that may not mix well with Esomep. For a full list see the leaflet inside your medicines packet.

What other drugs will affect Esomep?

Tell your doctor about all your current medicines. Many drugs can affect Esomep, especially:

This list is not complete and many other drugs may affect Esomep. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Q: What are the interactions, if any, between Plavix and Nexium? I had to switch from Protonix to Nexium for insurance reasons.

A: Since you are on Plavix (clopidogrel), you should not be taking Nexium (Esomep). New studies state that these products should not be taken together and that patients should use Zantac (ranitidine) or Pepcid (famotidine) instead. Contact your health care provider and let him or her know about the medication your insurance company put you on. Gerald S. Levy, RPh

Q: I am 23 years old. I was diagnosed with esophagitis and my doctor ask me to take Nexium 40 mg for all my life. I am worried that Nexium will cause osteoporosis, because I was had a hip fracture three years ago. So can Nexium cause osteoporosis, and how can I prevent that from happening?

A: Nexium (Esomep) (// is indicated for the treatment of GERD or gastroesophageal reflux disease. Nexium relieves heartburn that is caused by the backflow of stomach acid from the stomach to the esophagus. (// Common side effects associated with Nexium include dizziness, headache, diarrhea, constipation and dry mouth. Other less common side effects associated with Nexium include muscle pain, rash, back pain and chest pain. A search of prescribing information did not specifically list osteoporosis as an adverse event of Nexium. This is not a complete list of the side effects associated with Nexium. Kimberly Hotz, PharmD

Generic Name: Esomep Injection (ES oh MEP ra zole)Brand Name: Nexium I.V.

Medically reviewed by Last updated on Nov 1, 2019.

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