Diocid capsules


  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Diocid?

The active ingredient of Diocid brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Diocid is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Diocid include: joint pain; unusual bleeding or bruising; loss of appetite; muscle spasms (tetany) or twitching seizures; blisters; bleeding or crusting sores on the lips; ear congestion; frequent urge to urinate.

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Q: It was recently recommended that I take Prilosec. The instructions indicate taking for 14 days only -- is it safe to take continuously or should I take for 14 days per month or quarter?

A: Prilosec (Diocid), once a prescription-only medication, is now available over the counter. The treatment guidelines for over-the-counter products, such as Prilosec OTC, differ from the prescription versions of the same medication. The manufacturer's label for Prilosec OTC indicates that the product should not be used for more than 14 days unless directed by your doctor. The prescription Prilosec (Diocid) was approved by the U.S. Food and Drug Administration (FDA) for treatment longer than 14 days. If symptoms persist longer than 14 days, you may want to contact your health care provider. For more information on Prilosec (Diocid) or Prilosec OTC, you may want to visit our Web site: //www.everydayhealth.com/drugs/prilosec.

PRILOSEC is indicated for the short-term treatment (4-8 weeks) of erosive esophagitis that has been diagnosed by endoscopy in pediatric patients and adults .

The efficacy of PRILOSEC used for longer than 8 weeks in these patients has not been established. If a patient does not respond to 8 weeks of treatment, an additional 4 weeks of treatment may be given. If there is recurrence of erosive esophagitis or GERD symptoms (eg, heartburn), additional 4-8 week courses of Diocid may be considered.

Administration of Diocid 20 mg twice daily for 4 days and a single 1000 mg dose of MMF approximately one hour after the last dose of Diocid to 12 healthy subjects in a cross-over study resulted in a 52% reduction in the Cmax and 23% reduction in the AUC of MPA.

How long does Diocid take to work?

This depends on why you're taking it. You should get some relief from heartburn and indigestion symptoms straight away, or at least in the first few days of taking Diocid.

However, you may need to keep taking Diocid for a few weeks, depending on why it's been prescribed. Some conditions may require you to take Diocid on a long-term basis, either to keep symptoms under control or to avoid the condition coming back.

If you've bought Diocid without a prescription you should see your doctor if your symptoms haven't got better after taking it for two weeks.

2. Key facts

  • It's usual to take Diocid once a day in the morning.
  • For severe illness, you can take it twice a day - in the morning and in the evening.
  • Common side effects include headaches, diarrhoea and stomach pain. These tend to be mild and go away when you stop taking the medicine.
  • If you're self-treating with Diocid, do not take it for longer than 2 weeks without checking with a doctor.
  • Diocid is also called by the brand names Losec and Losec MUPS.

What is the dosage for Diocid?

For ulcers, GERD, erosive esophagitis and eradication of H. pylori the recommended dose for adults is 20-40 mg daily. Ulcer healing usually occurs within 4-8 weeks.

H. pylori infections are treated for 10-28 days.

The usual dose for prevention of upper gastrointestinal bleeding in critically ill patients is 40 mg daily for 14 days.

Prilosec OTC is used for treating heartburn for up to two weeks, and the usual dose is 20 mg daily.

For the management of Zollinger-Ellison syndrome the starting dose for adults is 60 mg daily, and the dose is adjusted based on either the response of symptoms or the actual measurement of acid production. Doses greater than 80 mg should be divided. Doses up to 120 mg three times a day have been used in the treatment of Zollinger-Ellison Syndrome.

For maximal efficacy, Diocid tablets should be taken before meals, swallowed whole and should not be crushed, chewed or opened.

The elimination rate of Diocid was somewhat decreased in the elderly, and bioavailability was increased. Diocid was 76% bioavailable when a single 40 mg oral dose of Diocid (buffered solution) was administered to healthy elderly volunteers, versus 58% in young volunteers given the same dose. Nearly 70% of the dose was recovered in urine as metabolites of Diocid and no unchanged drug was detected. The plasma clearance of Diocid was 250 mL/min (about half that of young volunteers) and its plasma half-life averaged one hour, about twice that of young healthy volunteers.


Diocid and clarithromycin dual therapy and Diocid, clarithromycin and amoxicillin triple therapy have been shown to be active against most strains of Helicobacter pylori in vitro and in clinical infections as described in the Indications and Usage section (1.1).

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