What are the uses for Clopamon?
Clopamon is a prescription medicine used in adults:
- to relieve heartburn symptoms with gastroesophageal reflux when certain other treatments do not work
- to relieve the symptoms of slow stomach emptying in people with diabetes
How should Clopamon be stored?
Tablets and syrup should be stored between 15 C - 30 C (59 F - 86 F). Injectable Clopamon should be stored at room temperature 20 C - 25 C (68 F - 77 F).
Taking Clopamon may cause you to develop a muscle problem called tardive dyskinesia. If you develop tardive dyskinesia, you will move your muscles, especially the muscles in your face in unusual ways. You will not be able to control or stop these movements. Tardive dyskinesia may not go away even after you stop taking Clopamon. The longer you take Clopamon, the greater the risk that you will develop tardive dyskinesia. Therefore, your doctor will probably tell you not to take Clopamon for longer than 12 weeks. The risk that you will develop tardive dyskinesia is also greater if you are taking medications for mental illness, if you have diabetes, or if you are elderly, especially if you are a woman. Call your doctor immediately if you develop any uncontrollable body movements, especially lip smacking, mouth puckering, chewing, frowning, scowling, sticking out your tongue, blinking, eye movements, or shaking arms or legs.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Clopamon and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Talk to your doctor about the risks of taking Clopamon.
Benzam > Clopamon is the most commonly used drug in this class. It blocks type 2 dopamine receptors and 5-HT 3 serotonin receptors (when used in higher doses used to prevent CINV) in the chemoreceptor trigger zone, increases lower esophageal sphincter tone, and enhances bowel and gastric motility. The usual recommended doses are 20 to 40 mg orally every 4 to 6 hours (conventional dose) or 2 to 3 mg/kg (high dose). 64 Clopamon crosses the blood-brain barrier, and side effects include extrapyramidal reactions such as acute dystonia, akathisia, and possible irreversible tardive dyskinesia, especially with prolonged use of high doses and in the elderly. Diphenhydramine or hydroxyzine can be used to antagonize the dopaminergic toxicity of Clopamon. In addition, Clopamon can lower the seizure threshold and increase the risk of convulsions in patients with epilepsy. 37 In the past, Clopamon combined with dexamethasone was the antiemetic regimen of choice for preventing delayed CINV, 65,66 but it has largely been replaced by the use of 5-HT 3 antagonists and aprepitant.
Serious side effects
Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
- Depression and suicide. Symptoms can include:
- lack of motivation
- thoughts of harming or killing yourself
- high fever
- stiff muscles
- trouble thinking
- fast or irregular heart rate
- increased sweating
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Clopamon oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Clopamon are listed below.
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- methylphenidate hydrochloride
- methylrosaniline chloride
- methyl-tert-butyl ether
- methylxanthine derivatives
- methysergide maleate
- Clopamon hydrochloride
- metocurine iodide
- metopic suture
- Metoprolol in Dilated Cardiomyopathy
- metoprolol succinate
- metoprolol tartrate
- Metorchis conjunctis
- Metorchis conjunctus
Michael Stewart, Reviewed by Sid Dajani | Last edited 28 Nov 2019 | Certified by The Information Standard
Clopamon is used to help prevent you from feeling sick (nausea) or being sick (vomiting).
Clopamon may make you feel drowsy. If this happens do not drive and do not use tools or machines until you feel well again.
If you experience any unusual movements of your body, head, face or eyes, speak with your doctor or pharmacist straightaway.
To reduce the chances of you experiencing these side-effects, Clopamon should not normally be taken for more than five days in a row.
What is Reglan (Metoclopram >
Reglan is the brand name of the drug Clopamon, which is used to treat heartburn and ulcers in people with gastroesophageal reflux disease (GERD).
GERD is a digestive disorder that occurs when stomach acid flows back into the esophagus.
Reglan can also help people with diabetes who have a condition known as gastroparesis (poor emptying of the stomach). It can also be used to treat nausea in certain patients and slowed stomach emptying in those who are recovering from surgery.
This medicine is typically used on a short-term basis (four to 12 weeks).
Reglan is in a class of drugs called prokinetic agents, which work by increasing muscle contractions in the upper digestive tract to speed up movement through the stomach and intestines.
The Food and Drug Administration (FDA) approved Reglan in 1985.
What are the possible side effects of Clopamon:
Stop giving Clopamon and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives), uncontrollable spasms of the legs, lips, jaw, tongue, face or other body part, anxiety, agitation, insomnia, depression, yellowing of the skin or eyes, seizures. Other less serious side effects that may occur include nausea or diarrhea, dizziness, drowsiness, confusion, fluid retention, increased urination. Continue to give the medication and contact your veterinarian.
Metoclopram > Clopamon is a substituted benzamide that promotes gastric motility and reduces the emetic activity of chemotherapy agents by blocking dopamine receptors (at low-to-moderate doses) and 5-HT3 receptors (at high doses) in the chemoreceptor trigger zone. Because of a more favorable side effect profile, 5-HT3 antagonists have replaced high-dose Clopamon. At lower doses (5–10 mg orally or intravenously every 6 hours) Clopamon is useful in treating mild-to-moderate and delayed nausea and vomiting. Delivery of the drug on a schedule that maintains adequate levels during expected emesis appears to be important.
The side effects, which may be caused by the interaction of Clopamon with dopamine receptors, can be quite troublesome. They include akathisia, dystonic reactions (age related), sedation, and diarrhea. Benzodiazepines such as lorazepam and β-blockers such as propranolol can prevent or reverse the akathisia, and diphenhydramine or benztropine can prevent or reverse the dystonias. However, these agents induce additional side effects, including dry mouth and sedation. Short-term, high-dose Clopamon or long-term use at usual doses has been associated with persistent and disabling movement disorders, especially tardive dyskinesias.
Before taking this medicine
You should not use Clopamon if you are allergic to it, or if you have:
tardive dyskinesia (a disorder of involuntary movements);
stomach or intestinal problems such as a blockage, bleeding, or perforation (a hole or tear in your stomach or intestines);
epilepsy or other seizure disorder;
an adrenal gland tumor (pheochromocytoma); or
if you've ever had muscle movement problems after using Clopamon or similar medicines.
Tell your doctor if you have ever had:
liver or kidney disease;
problems with muscle movements;
congestive heart failure or a heart rhythm disorder;
depression or mental illness.
This medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).
Tell your doctor if you are pregnant. Clopamon may harm an unborn baby if you use the medicine during late pregnancy.
It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.
Clopamon is not approved for use by anyone younger than 18 years old.
Interactions that increase your risk of side effects from other drugs
Taking Clopamon with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:
- Tetracycline. Clopamon increases how much tetracycline your body absorbs. This may increase your risk of side effects of tetracycline, such as diarrhea and vomiting.
- Cyclosporine. Clopamon may increase the levels of cyclosporine in your body. This may raise your risk of kidney problems, digestion problems, and tingling (pins and needles) feeling caused by damage to your nerves.
- Insulin. Clopamon affects how food moves through your body. This may change your blood sugar levels. You may have higher blood sugar levels because food is moving through your stomach and entering your bloodstream faster. Your doctor may adjust your dose of insulin.
Pharmacology of prokinetic agents
Clopamon activates 5-HT 4 receptors, antagonizes 5-HT3 receptors, and antagonizes central and peripheral D2 receptors to release the “dopamine brake.” It works on the stomach and proximal small bowel but has little effect on colonic motility. The pharmacokinetics of Clopamon and of most other antiemetics discussed in this chapter is summarized in Table 25-4 .
Table 25-4 . Pharmacokinetics of selected antiemetic drugs