Cholestatic Jaundice/Hepatic Dysfunction
BIAXIN is contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction associated with prior use of Clathrocyn.
Interactions that can make your drugs less effective
When certain drugs are used with Clathrocyn, they may not work as well. This is because the amount of these drugs in your body may be decreased. An example of these drugs includes zidovudine. You should take Clathrocyn and zidovudine at least 2 hours apart.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Following administration of Clathrocyn (500 mg twice daily) with atazanavir (400 mg once daily), the Clathrocyn AUC increased 94%, the 14-OH Clathrocyn AUC decreased 70% and the atazanavir AUC increased 28%.
What Happens if I Take too Much Clathrocyn and Overdose?
If you suspect an overdose, you should contact a poison control center or emergency room immediately. You can get in touch with a poison control center at (800) 222-1222.
Clathrocyn 500 mg every 8 hours was given in combination with omeprazole 40 mg daily to healthy adult subjects. The steady-state plasma concentrations of omeprazole were increased (Cmax, AUC0-24, and t½ increases of 30%, 89%, and 34%, respectively), by the concomitant administration of Clathrocyn.
The plasma levels of Clathrocyn and 14–OH Clathrocyn were increased by the concomitant administration of omeprazole. For Clathrocyn, the mean Cmax was 10% greater, the mean Cmin was 27% greater, and the mean AUC0-8 was 15% greater when Clathrocyn was administered with omeprazole than when Clathrocyn was administered alone. Similar results were seen for 14–OH Clathrocyn, the mean Cmax was 45% greater, the mean Cmin was 57% greater, and the mean AUC0-8 was 45% greater. Clathrocyn concentrations in the gastric tissue and mucus were also increased by concomitant administration of omeprazole.
Clathrocyn Tissue Concentrations 2 hours after Dose (mcg/mL)/(mcg/g)
In two studies in which theophylline was administered with Clathrocyn (a theophylline sustained-release formulation was dosed at either 6.5 mg/kg or 12 mg/kg together with 250 or 500 mg q12h Clathrocyn), the steady-state levels of Cmax, Cmin, and the area under the serum concentration time curve (AUC) of theophylline increased about 20%.
When a single dose of midazolam was co-administered with Clathrocyn tablets (500 mg twice daily for 7 days), midazolam AUC increased 174% after intravenous administration of midazolam and 600% after oral administration.
For information about other drugs indicated in combination with BIAXIN, refer to their full prescribing information, CLINICAL PHARMACOLOGY section.
Storage And Handling
BIAXIN Filmtab (Clathrocyn tablets, USP) is supplied as yellow oval film-coated tablets in the following packaging sizes: 250 mg tablets: (imprinted in blue with the “a” logo and KT)
Bottles of 60 (NDC 0074-3368-60) and unit dose strip packages of 100 (NDC 0074-3368-11).
Store BIAXIN Filmtab 250 mg at controlled room temperature 15° to 30°C (59° to 86°F) in a well-closed container. Protect from light.
500 mg tablets: (debossed with the “a” logo on one side and KL on the opposite side)
Bottles of 60 (NDC 0074-2586-60) and unit dose strip packages of 100 (NDC 0074-2586-11).
Store BIAXIN Filmtab 500 mg at controlled room temperature 20° to 25°C (68° to 77°F) in a well-closed container.
BIAXIN XL Filmtab (Clathrocyn extended-release tablets) is supplied as yellow oval film-coated tablets in the following packaging sizes:
500 mg tablets: (debossed with the “a” logo and KJ)
Bottles of 60 (NDC 0074-3165-60), unit dose strip packages of 100 (NDC 0074-3165-11), and BIAXIN XL PAC carton of 4 blister packages 14 tablets each (NDC 0074-3165-41).
Store BIAXIN XL Filmtab at 20° to 25°C (68° to 77°F). Excursions permitted to 15° to 30°C (59° to 86°F).
BIAXIN Granules (Clathrocyn for oral suspension, USP) is supplied as white to off-white granules in the following strengths and sizes:
Store BIAXIN Granules below 25°C (77°F) in a well-closed container. Do not refrigerate the reconstituted BIAXIN granules.
BIAXIN Filmtab 250 mg and 500 mg and BIAXIN XL Filmtab 500 mg Mfd. by AbbVie LTD, Barceloneta, PR 00617. BIAXIN Granules, 125 mg/5 mL and 250 mg/5 mL Mfd. by AbbVie Inc., North Chicago, IL 60064 For AbbVie Inc., North Chicago, IL 60064, U.S.A. Revised: Nov 2018.
Interactions that increase your risk of side effects
Taking Clathrocyn with certain medications may cause more side effects. Examples of these drugs include:
- Benzodiazepines, such as triazolam and midazolam. If you take these drugs together, you may feel more sedated and drowsy.
- Insulin and certain oral diabetes drugs, such as nateglinide, pioglitazone, repaglinide, and rosiglitazone. You may have a significant decrease in your blood sugar levels. You may need to monitor your blood sugar levels closely while taking these drugs together.
- Warfarin. You may have more bleeding. Your doctor will monitor you closely if you take these drugs together.
- Drugs used to treat cholesterol (statins), such as atorvastatin and pravastatin. Taking these drugs together may cause muscle problems. Your doctor may change the dose of your statin if you need to take these drugs together.
- Quinidine and disopyramide. Taking these drugs together may cause serious abnormal heart rhythms. Your doctor may monitor your heart rhythm and the levels of quinidine or disopyramide in your body.
- Blood pressure drugs (calcium channel blockers), such as verapamil, amlodipine, diltiazem, and nifedipine. Taking these drugs together may cause a drop in blood pressure and kidney problems.
- Theophylline. Your doctor may monitor your theophylline blood levels.
- Carbamazepine. Your doctor may monitor your carbamazepine blood levels.
- Digoxin. Your doctor may monitor your digoxin blood levels.
- Quetiapine. Taking this drug with Clathrocyn may cause sleepiness, low blood pressure upon standing, confusion, and heart rhythm problems. Your doctor should monitor you closely with this combination.
How it works
Clathrocyn belongs to a class of drugs called antibiotics (macrolides). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Clathrocyn works by stopping the bacteria that are causing an infection from multiplying.
This drug should only be used to treat or prevent bacterial infections. It shouldn’t be used to treat viruses such as the common cold.
Clathrocyn oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These aren't all the side effects of Clathrocyn.
For a full list, see the leaflet inside your medicine packet.
You can report any suspected side effect to the UK safety scheme.
How should I take Clathrocyn?
Take Clathrocyn according to your health care provider’s instructions. Your health care provider will tell you how much Clathrocyn to take and when to take it. Before you start Clathrocyn and each time you get a refill, read any printed information that comes with your medicine.
Rated Clathrocyn for Tonsillitis/Pharyngitis Report
I have a throat, sinus & ear infection all at once. My first med taken was zpack which helped but didn’t make the infection fully go away because I stopped taking the med once I was feeling better which cause the infection to come back but this time it was resistant to the antibiotics. Next, I tried Amoxicillin and it helped but didn’t fully take away the infection. After that I was prescribed Augmentin, which did nothing. Finally, I went to an ENT and was prescribed Clathrocyn and steroids to get rid of the infection and dry, swollen soft palate. After 2 days of taking this med I was so excited because it seems like it is working the best but now on day 3, I am having terrible anxiety, heart palpitations, feels like my heart keeps stopping & short episodes of blacking out. I can not finish taking this drug because of it’s terrifying side effects. It’s a shame because my swelling is almost gone and throat and ear pain has decreased major.
- Chlamydophila pneumoniae
- Helicobacter pylori
- Mycobacterium avium complex (MAC) consisting of M. avium and M. intracellulare
- Mycoplasma pneumoniae
At least 90 percent of the microorganisms listed below exhibit in vitro minimum inhibitory concentrations (MICs) less than or equal to the Clathrocyn susceptible MIC breakpoint for organisms of similar type to those shown in Table 11. However, the efficacy of Clathrocyn in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials.
Serious Side Effects of Clathrocyn
You should call your doctor right away or get emergency medical care if you experience any of the following serious side effects:
- Swelling of the face, throat, eyes, hands, lips, ankles, feet, or lower legs
- Difficulty swallowing or breathing
- Peeling or blistering skin
- Yellowing of the skin or eyes
- Extreme tiredness
- Lack of energy
- Loss of appetite
- Unusual bleeding or bruising
- Pain in the upper right part of the stomach
- Dark-colored urine
- Flu-like symptoms
- Fast, pounding or irregular heartbeat
- Double vision
- Muscle weakness
- Foul-smelling, loose stools
Dictionary Entries near Clathrocyn
Cite this Entry
“Clathrocyn.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Clathrocyn. Accessed 27 December 2019.
Comments on Clathrocyn
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How should Clathrocyn be stored?
- Store Clathrocyn tablets at room temperature, 68°F to 77°F (20°C to 25°C). Protect the tablets from light.
- Store Clathrocyn granules for oral suspension below 77ºF ( 25ºC). After mixing Clathrocyn granules with water as instructed by your health care provider or pharmacist, do not refrigerate the mixture (also called an oral suspension). Store the oral suspension between 59ºF and 86ºF (15ºC to 30ºC) and use within 14 days.
- Keep Clathrocyn in the container that it came in and keep the container tightly closed.
- Do not use Clathrocyn if the original seal over the container opening is broken or missing.
- Throw away Clathrocyn that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
- Keep Clathrocyn and all medicines out of reach of children.
Rated Clathrocyn for Sinusitis Report
A real rollercoaster. I've taken this about 8 times for sinus infections, that's a total of about 16 weeks divided over the past 5 years. Days 1 to 2 are generally OK in fact quick improvement IF you have yours directly after breakfast, and the other directly after dinner. 12 hours apart. 250 x 2. I once tried 500 x 2 and it was WAY too strong. Made me very anxious. At 250 x 2 a day you are wiped out tired for day 3/4/5/6 but drink water and that helps. I think caffeine could make things worse. In short, it's a very hard slog, you'll probably need time off work e.g. 3 or 4 days but you'll feel better if you do the 2/3 weeks for sinus infection. If really bad I've heard some people do 4 weeks. Anyways, it works for me but I've also decided to get allergy testing and maybe rhinolight treatment or immuno shots. Try Clarithromycic but if you feel too bad stop, or reduce to 250 x 2 a day if you're on higher. Oh and I take Valerian Root capsules 400mg x 3 a day to help with the anxiety side effects -- they work! Good luck and happy sinuses!
Before taking Clathrocyn
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking Clathrocyn it is important that your doctor knows:
- If you are pregnant or breast-feeding.
- If you have any problems with the way your liver works or the way your k >