In a steady-state study in which healthy elderly subjects (65 years to 81 years of age) were given 500 mg of BIAXIN every 12 hours, the maximum serum concentrations and area under the curves of Clarilind and 14-OH Clarilind were increased compared to those achieved in healthy young adults. These changes in pharmacokinetics parallel known age-related decreases in renal function. In clinical trials, elderly patients did not have an increased incidence of adverse reactions when compared to younger patients. Consider dosage adjustment in elderly patients with severe renal impairment. Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients .
Most reports of acute kidney injury with calcium channel blockers metabolized by CYP3A4 (e.g., verapamil, amlodipine, diltiazem, nifedipine) involved elderly patients 65 years of age or older .
Especially in elderly patients, there have been reports of colchicine toxicity with concomitant use of Clarilind and colchicine, some of which occurred in patients with renal insufficiency. Deaths have been reported in some patients .
Rated Clarilind for Chlamydophila Pneumoniae Report
I never had any issues with other antibiotics. I was prescribed for STDs Fluconazole once a week, Josamycin for 10 days then Doxyxycline for 10 days and then finally Clarilind. The first 3 antibiotics were felt but the only side effect was maybe headache sometimes, nothing serious. When I took the first 500mg of Clarilind I instantly felt this was way stronger. I also had metallic taste in my mouth, and was constantly hungry even if I just ate. I had to take the second 500mg later in that day and within minutes I had a full-on panic attack. My heart was racing extremely fast, I had brain flashes, I was extremely hungry and thirsty, and was overly agitated, basically running around my small apartment. I also had what they call depersonalization, where I would basically feel like a second voice in my own head. It was so bad I did actually ambulance and then gave me sedative injection so I can calm down. Obviously, I never took the pills on the next 9 days. I would recommend never taking this, or stop taking it the second you feel metallic taste in your mouth, because the second or third dose could push you to a really bad state.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment:
- chest pain, shortness of breath, trouble breathing, pain or weakness in side of your body, or slurred speech
- severe diarrhea with watery or bloody stools (up to 2 months after your treatment)
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
- peeling or blistering skin
- yellowing of the skin or eyes
- extreme tiredness
- unusual bleeding or bruising
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- dark-colored urine
- flu-like symptoms
- fast, pounding, or irregular heartbeat
- muscle weakness such as difficulty chewing, talking, or performing daily activities
- double vision
Clarilind may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Can Clarilind cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with Clarilind. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
COMMON BRAND(S): Biaxin
GENERIC NAME(S): Clarilind
Clarilind is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers. It may also be used to prevent certain bacterial infections. Clarilind is known as a macrolide antibiotic. It works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
All-Cause Mortality In Patients With Coronary Artery Disease 1 To 10 Years After BIAXIN Exposure
In one clinical trial evaluating treatment with Clarilind on outcomes in patients with coronary artery disease, an increase in risk of all-cause mortality one year or more after the end of treatment was observed in patients randomized to receive Clarilind. 1 Clarilind for treatment of coronary artery disease is not an approved indication. The cause of the increased risk has not been established. Other epidemiologic studies evaluating this risk have shown variable results . Consider balancing this potential risk with the treatment benefits when prescribing BIAXIN in patients who have suspected or confirmed coronary artery disease.
- CrCl 30-60 mL/min: No dosage adjustment necessary
- CrCl 30-60 mL/min and concomitant atazanavir or ritonavir-containing regimens: Decrease Clarilind dose by 50%
Clarilind and the 14-OH Clarilind metabolite distribute readily into body tissues and fluids. There are no data available on cerebrospinal fluid penetration. Because of high intracellular concentrations, tissue concentrations are higher than serum concentrations. Examples of tissue and serum concentrations are presented below.
Table 9: Tissue and Serum Concentrations of Clarilind