Mechanism Of Action
Claricide is a macrolide antimicrobial drug .
Claricide 500 mg every 8 hours was given in combination with omeprazole 40 mg daily to healthy adult subjects. The steady-state plasma concentrations of omeprazole were increased (Cmax, AUC0-24, and t½ increases of 30%, 89%, and 34%, respectively), by the concomitant administration of Claricide.
The plasma levels of Claricide and 14–OH Claricide were increased by the concomitant administration of omeprazole. For Claricide, the mean Cmax was 10% greater, the mean Cmin was 27% greater, and the mean AUC0-8 was 15% greater when Claricide was administered with omeprazole than when Claricide was administered alone. Similar results were seen for 14–OH Claricide, the mean Cmax was 45% greater, the mean Cmin was 57% greater, and the mean AUC0-8 was 45% greater. Claricide concentrations in the gastric tissue and mucus were also increased by concomitant administration of omeprazole.
Claricide Tissue Concentrations 2 hours after Dose (mcg/mL)/(mcg/g)
In two studies in which theophylline was administered with Claricide (a theophylline sustained-release formulation was dosed at either 6.5 mg/kg or 12 mg/kg together with 250 or 500 mg q12h Claricide), the steady-state levels of Cmax, Cmin, and the area under the serum concentration time curve (AUC) of theophylline increased about 20%.
When a single dose of midazolam was co-administered with Claricide tablets (500 mg twice daily for 7 days), midazolam AUC increased 174% after intravenous administration of midazolam and 600% after oral administration.
For information about other drugs indicated in combination with BIAXIN, refer to their full prescribing information, CLINICAL PHARMACOLOGY section.
Rated Claricide for Helicobacter pylori Infection Report
Absolutely minging taste. Had me up in the night loads and I can’t bare to carry them on. Also, nausea and headaches. I came home early from work as I felt so rubbish. If you can complete a week of these, you deserve a medal ??
How to use Claricide
Take this medication by mouth with or without food as directed by your doctor, usually every 12 hours. If stomach upset occurs, you may take it with food or milk.
For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage may also be based on weight.
If you are using this medication to treat an infection, continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.
If you are taking this medication to prevent certain bacterial infections, take it exactly as directed by your doctor. Do not stop taking the medication without your doctor's approval. Tell your doctor if you develop signs of infection such as fever or night sweats.
What Happens if I Miss a Dose of Claricide or Don't Take It as Prescribed?
If you miss a dose of Claricide, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue on your regular dosing schedule. Do not take a double dose to make up for a missed dose.