Claribid should not be used in pregnant women except in clinical circumstances where no alternative therapy is appropriate. If BIAXIN is used during pregnancy, or if pregnancy occurs while the patient is taking this drug, the patient should be apprised of the potential hazard to the fetus. Claribid has demonstrated adverse effects on pregnancy outcome and/or embryo-fetal development in monkeys, rats, mice, and rabbits at doses that produced plasma levels 2 times to 17 times the serum levels achieved in humans treated at the maximum recommended human doses .
Michael Stewart, Reviewed by Sid Dajani | Last edited 31 May 2017 | Certified by The Information Standard
Claribid is a macrolide antibiotic. It can be taken by people who are allergic to penicillin.
It is important to complete the prescribed course (unless you are told to stop). Otherwise your infection could come back.
Any side-effects are usually mild. The most common are diarrhoea, feeling sick (nausea), tummy (abdominal) discomfort, and unusual tastes.
Decreases in MAC bacteremia or negative blood cultures were seen in the majority of patients in all BIAXIN dosage groups. The mean reductions in MAC colony forming units (CFU) from baseline after 4 weeks of therapy in the 1000 mg (n=32) twice daily and 2000 mg (n=26) twice daily regimen was 2.3 Log CFU compared to 1.5 Log CFU in the BIAXIN 500 mg twice daily (n=35) regimen. A separate trial with a four-drug regimen 2 (ciprofloxacin, ethambutol, rifampicin, and clofazimine) had a mean reduction of 1.4 Log CFU.
Clinical outcomes evaluated with the different dosing regimens of Claribid monotherapy are shown in Table 14. The 1000 mg and 2000 mg twice daily doses showed significantly better control of bacteremia during the first four weeks of therapy. No significant differences were seen beyond that point. All of the isolates had MIC less than 8 mcg/mL at pre-treatment. Relapse was almost always accompanied by an increase in MIC.
Table 14: Outcome with the Different Dosing Regimens of BIAXIN
Concomitant administration of BIAXIN with cisapride and pimozide is contraindicated .
There have been postmarketing reports of drug interactions when Claribid is co-administered with cisapride or pimozide, resulting in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) most likely due to inhibition of metabolism of these drugs by BIAXIN. Fatalities have been reported.
Rated Claribid for Streptococcus Agalactiae (group B Streptococci) Report
I was initially put on amoxicillin for strep throat. After a week had passed my infection got much worse, it had spread to my lungs which had caused wheezy bronchitis and also to my tonsils as I also had tonsillitis. So they put me on 500mg Claribid for 10 days to treat all three infections. The first night was not too bad, but after that I felt the worst I had ever felt in my entire life. I did not manage to sleep for about 6 days, I already had anxiety which was being managed through CBT, but this medicine made it very bad. I had severe hallucinations, migraines, extreme fatigue, paranoia, GERD issues and I also convinced myself I was hearing things. I have had bad reactions to some medicines before, but nowhere near as bad as this, in hindsight it cured my infection but I would strongly advise to not go near this medicine unless it is your absolute last resort.
Outcome and Management
The minor serum aminotransferase elevations that appear during therapy with Claribid are usually benign, asymptomatic and resolve rapidly whether or not Claribid is stopped. The acute hepatic injury with jaundice, however, can be prolonged and troublesome and lead to loss of intrahepatic bile ducts and vanishing bile duct syndrome. Rare instances of fatality from Claribid induced liver disease have been reported. It is unclear whether there is cross sensivity to hepatic injury about the different macrolide antibiotics, but after severe injury from one macrolide, it is prudent to avoid use of the others.
How it works
Claribid belongs to a class of drugs called antibiotics (macrolides). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Claribid works by stopping the bacteria that are causing an infection from multiplying.
This drug should only be used to treat or prevent bacterial infections. It shouldn’t be used to treat viruses such as the common cold.
Claribid oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Rated Claribid for Sinusitis Report
I was prescribed this medication after suffering from a sinus infection for 2 weeks then throat and chest infection I was totally fed up and in agony but as a student nurse out on placement I persevered for as long as possible before going to the docs. Yep I experienced diarrhoea for the first 2 days but I could feel it drying up and clearing up my infection and slept loads better. I think you need to weigh up how Ill you feel with the possible side effects. By the time I was prescribed this medication I was done in completely and anything was better than feeling so bad so I put up with it and I’m on the mend at last! On my 4th day and I will continue as I’m feeling better. Each to their own everyone is different
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Claribid is also given to get rid of Helicobacter pylori. This is the bacterium believed to cause stomach ulcers. If you are prescribed it for this reason, you will also be prescribed other medicines to take alongside it.
All-Cause Mortality In Patients With Coronary Artery Disease 1 To 10 Years After BIAXIN Exposure
In one clinical trial evaluating treatment with Claribid on outcomes in patients with coronary artery disease, an increase in risk of all-cause mortality one year or more after the end of treatment was observed in patients randomized to receive Claribid. 1 Claribid for treatment of coronary artery disease is not an approved indication. The cause of the increased risk has not been established. Other epidemiologic studies evaluating this risk have shown variable results . Consider balancing this potential risk with the treatment benefits when prescribing BIAXIN in patients who have suspected or confirmed coronary artery disease.
What should I avoid while taking Claribid?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
A randomized, double-blind clinical trial (trial 3) compared Claribid 500 mg twice a day to placebo in patients with CDC-defined AIDS and CD4 counts less than 100 cells/μL. This trial accrued 682 patients from November 1992 to January 1994, with a median CD4 cell count at entry of 30 cells/mcL. Median duration of BIAXIN was 10.6 months vs. 8.2 months for placebo. More patients in the placebo arm than the BIAXIN arm discontinued prematurely from the trial (75.6% and 67.4%, respectively). However, if premature discontinuations due to Mycobacterium avium complex (MAC) or death are excluded, approximately equal percentages of patients on each arm (54.8%) on BIAXIN and 52.5% on placebo) discontinued study drug early for other reasons. The trial was designed to evaluate the following endpoints:
- MAC bacteremia, defined as at least one positive culture for Mycobacterium avium complex bacteria from blood or another normally sterile site
- Clinically significant disseminated MAC disease, defined as MAC bacteremia accompanied by signs or symptoms of serious MAC infection, including fever, night sweats, weight loss, anemia, or elevations in liver function tests
In patients randomized to BIAXIN, the risk of MAC bacteremia was reduced by 69% compared to placebo. The difference between groups was statistically significant (p
Table 13: Mortality Rates at 18 months in Trial 3
Clinically Significant Disseminated MAC Disease
In association with the decreased incidence of MAC bacteremia, patients in the group randomized to BIAXIN showed reductions in the signs and symptoms of disseminated MAC disease, including fever, night sweats, weight loss, and anemia.
Rated Claribid for Helicobacter pylori Infection Report
Absolutely minging taste. Had me up in the night loads and I can’t bare to carry them on. Also, nausea and headaches. I came home early from work as I felt so rubbish. If you can complete a week of these, you deserve a medal ??
The concomitant use of BIAXIN and oral hypoglycemic agents and/or insulin can result in significant hypoglycemia. With certain hypoglycemic drugs such as nateglinide, pioglitazone, repaglinide and rosiglitazone, inhibition of CYP3A enzyme by Claribid may be involved and could cause hypoglycemia when used concomitantly. Careful monitoring of glucose is recommended .
Dictionary Entries near Claribid
Cite this Entry
“Claribid.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Claribid. Accessed 27 December 2019.
Comments on Claribid
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Rated Claribid for Upper Respiratory Tract Infection Report
It’s good as an alternative to penicillin if you’re allergic & it works great! But, be prepared to have diarrhea at some point on it. I seem to have diarrhea every time I am on this antibiotic.
Rated Claribid for Streptococcus Pneumoniae Report
I wish I had read other reviews before having taken Claribid. I took it 8 1/2 years ago and stuck it out for about half of my 14 day prescription. I had severe anxiety, hallucinations, severe claustrophobia, noise intolerance, raw skin under my eyes, racing heartbeat, peripheral bounding pulse, and severe insomnia. 8 1/2 years later, I still have anxiety, peripheral bounding pulse, and insomnia. Do not take this drug. I do not usually write reviews like this, but this drug has changed my life. I wish I could go back and take something different. I am finally finding treatment that looks hopeful in helping combat these side effects.