Clarac tablets

Clarac

  • Active Ingredient: Clarithromycin
  • 500 mg, 250 mg
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What is Clarac?

The active ingredient of Clarac brand is clarithromycin. Clarithromycin is a macrolide antibiotic. Clarithromycin fights bacteria in your body. Clarithromycin is a white to off-white crystalline powder. It is soluble in acetone, slightly soluble in methanol, ethanol, and acetonitrile, and practically insoluble in water. Clarithromycin tablets, USP are intended for oral administration and contain 250 mg or 500 mg of Clarithromycin, USP. In addition, each Clarithromycin tablet contains the following inactive ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, povidone, talc, and titanium dioxide.

Used for

Clarac is used to treat diseases such as: Bacterial Endocarditis Prevention, Bronchitis, Dental Abscess, Follicular Lymphoma, Helicobacter Pylori Infection, Legionella Pneumonia, Mycobacterium avium-intracellulare, Prophylaxis, Mycobacterium avium-intracellulare, Treatment, Mycoplasma Pneumonia, Nongonococcal Urethritis, Otitis Media, Pertussis, Pertussis Prophylaxis, Pharyngitis, Pneumonia, Sinusitis, Skin and Structure Infection, Skin or Soft Tissue Infection, Strep Throat, Tonsillitis/Pharyngitis, Toxoplasmosis, Upper Respiratory Tract Infection.

Side Effect

Possible side effects of Clarac include: excess air or gas in the stomach or intestines; skin rash and itching; lower back or side pain; sore throat; loss of taste; feeling that others are watching you or controlling your behavior; heartburn.

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Other uses for this medicine

Clarac also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), cryptosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease, (type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to Clarac.

How should Clarac be stored?

  • Store Clarac tablets at room temperature, 68°F to 77°F (20°C to 25°C). Protect the tablets from light.
  • Store Clarac granules for oral suspension below 77ºF ( 25ºC). After mixing Clarac granules with water as instructed by your health care provider or pharmacist, do not refrigerate the mixture (also called an oral suspension). Store the oral suspension between 59ºF and 86ºF (15ºC to 30ºC) and use within 14 days.
  • Keep Clarac in the container that it came in and keep the container tightly closed.
  • Do not use Clarac if the original seal over the container opening is broken or missing.
  • Throw away Clarac that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep Clarac and all medicines out of reach of children.

How does Clarac work?

It works by preventing bacteria from producing proteins that are essential to them. Without these proteins the bacteria cannot grow, replicate and increase in numbers. The bacteria eventually die or are destroyed by the immune system. This clears up the infection.

Introduction

Clarac is a semisynthetic macrolide antibiotic used for a wide variety of mild-to-moderate bacterial infections. Clarac has been linked to rare instances of acute liver injury that can be severe and even fatal.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Clarac only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 21.01.

Rated Clarac for Pneumonia Report

I honestly am so grateful for this drug. I got double pneumonia and amoxicillin did absolutely nothing for it. The gp prescribed Clarac and although i was ill for a while it was the only thing that worked. Yes it tastes absolutely disgusting and you wake up with the taste throughout the night. but id take that any day over double pneumonia.

Contraindications

  • Documented hypersensitivity
  • Coadministration with pimozide, cisapride, ergotamine, and dihydroergotamine
  • History of cholestatic jaundice or hepatic dysfunction associated with previous use of Clarac
  • Coadministration with colchicine in patients with kidney (renal) or liver (hepatic) impairment
  • Coadministration with HMG-CoA reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (lovastatin, simvastatin), due to the increased risk of muscle disease (myopathy), including destruction of muscle tissue (rhabdomyolysis)

Effects of Drug Abuse

  • No information available

  • See "What Are Side Effects Associated with Using Clarac?"

  • See "What Are Side Effects Associated with Using Clarac?"

  • Severe kidney (renal) impairment
  • Oral solution must not be refrigerated
  • Not for use in pregnancy, except when there is no alternative therapy; apprise patient about potential hazard to fetus if pregnancy occurs while in therapy
  • Use for endocarditis prophylaxis is appropriate only for high-risk patients, per American Heart Association (AHA) guidelines
  • Associated with heart rhythm disorder (QT interval prolongation) and infrequent cases of arrhythmias, including torsade de pointes; avoid using with ongoing proarrhythmic conditions (uncorrected low blood levels of potassium or low blood levels of magnesium), clinically significant slow heart rate; do not coadminister with class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol) antiarrhythmics
  • Elderly patients may be more susceptible to drug-associated hear rate disorder (QT prolongation)
  • Use caution in patients with coronary artery disease; postmarketing trials suggest increased risk of cardiovascularmortality
  • Discontinue immediately if severe hypersensitivity reactions occur (severe allergic reaction (anaphylaxis), Stevens-Johnson syndrome, TEN, drug reaction with eosinophilia and systemic symptoms syndrome, Henoch-Schonlein purpura)
  • Clostridium difficile associated diarrhea reported with use of nearly all antibacterial agents, including Clarac
  • May cause kidney injury when administered concomitantly with calcium channel blockers metabolized by CYP3A4
  • Do not coadminister with ranitidine/bismuth citrate with history of acute porphyria or if Creatinine Clearance under 25 mL/min
  • Coadministration with quetiapine may result in quetiapine related toxicities including neurolepticmalignant syndrome, heart rhythm disorder (QT prolongation), sleepiness, dizziness upon standing, altered state of consciousness
  • Exacerbation of myasthenia gravis or new onset of symptoms reported
  • Hepatic dysfunction
  • Increased liver enzyme activity and hepatocellular or cholestatic hepatitis, with or without jaundice, have been reported; this may be severe and is usually reversible
  • In some instances, hepatic failure with fatal outcome has been reported, generally in association with serious underlying diseases or concomitant medications
  • Discontinue Clarac immediately if signs and symptoms of hepatitis occur (anorexia, jaundice, dark urine, pruritus, or tender abdomen)

  • Use Clarac during pregnancy with caution if benefits outweigh risks. Animal studies show risk and human studies are not available, or neither animal nor human studies were done
  • Clarac is excreted in breast milk; use with caution if breastfeeding. Consult your doctor

How should I take Clarac?

Take Clarac exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not use this medicine to treat any condition that has not been checked by your doctor. Do not share this medicine with another person, even if they have the same symptoms you have.

You may take the regular tablets and oral suspension (liquid) with or without food.

Clarac extended-release tablets (Biaxin XL) should be taken with food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Shake the oral liquid well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Clarac is usually given for 7 to 14 days. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Clarac will not treat a viral infection such as the flu or a common cold.

Store this medicine in the original container at room temperature, away from moisture, heat, and light.

Do not keep the oral liquid in a refrigerator. Throw away any liquid that has not been used within 14 days.

If your infection is treated with a combination of drugs, use all medications as directed by your doctor. Read the instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

Mechanism Of Action

Clarac is a macrolide antimicrobial drug .

Rated Clarac for Pneumonia Report

Was prescribed this for suspected atypical pneumonia after a 7 day course of amoxycillin do not clear it. On Day 7 now - it seems to be effective in clearing the pneumonia but the side effects are much worse than amoxycillin: persistent metallic/ bitter taste in mouth, low mood and tearfulness started about Day 2-3 and have continued, strange dreams, disturbed sleep/ early morning waking with dry mouth/ dry cough, mild nausea and upset stomach/ cramps/ diarrhoea. Wide range of drug side effects but on the other hand, the chest infection has cleared and those symptoms were actually worse (fever, sore muscles, sore throat, coughing and shortness of breath - unable to do anything apart from staying bed), so was probably worth it overall.


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