NEXIUM (Asector magnesium - capsule, delayed rel pellets;oral)
- Manufacturer: ASTRAZENECA PHARMS Approval date: February 20, 2001 Strength(s): EQ 20MG BASE , EQ 40MG BASE
4. How and when to take it
It's usual to take Asector once a day, first thing in the morning. You can take it with or without food.
If you take Asector twice a day, take one dose in the morning and one dose in the evening.
Swallow tablets whole with a drink of water. If you have problems swallowing tablets, you can put them in a glass of water. Stir until the tablets start to break up, then drink straight away.
If you have problems swallowing capsules, you can open up Asector capsules and empty the contents into a glass. Mix with some water and drink straight away. Fill the glass with water again, and drink that as well to make sure there's no medicine left at the bottom of the glass.
If your child is under 12 years old, their doctor may prescribe Asector granules which come in sachets. Empty the granules into a glass and mix with some water, then encourage them to drink it straight away.
Q: How long can you take Nexium without serious complications? Can it cause throat polyps?
A: Nexium (Asector) is in a drug class called proton pump inhibitors. Nexium is used to treat gastroesophageal reflux disease (GERD). Nexium is also used to prevent ulcers (sores in the lining of the stomach) in people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). In combination with certain other medications, Nexium is used to treat and prevent the recurrence of stomach ulcers caused by H. pylori, a type of bacteria. Nexium is also used to treat conditions (e.g., Zollinger-Ellison Syndrome) in which the stomach makes too much acid. Nexium works be reducing acid production in the stomach. The safety of Nexium has been assessed in over 15,000 people in clinical trials around the world, according to its prescribing information. Over 2900 people were treated with Nexium in long-term studies -- up to 6 to 12 months. Generally, Nexium was well tolerated in short-term and long-term clinical trials. The most common side effects with Nexium are: headache, diarrhea, nausea, excessive gas, abdominal pain, constipation, and dry mouth. Atrophic gastritis has been reported in people treated long-term with omeprazole. Structurally, omperazole is a mirror image of Nexium. Atrophic gastritis is a condition where the normal glands of the stomach are decreased or absent; inflammation is present; and stomach cells are damaged. Atrophic gastritis is a precursor for stomach cancer. The cancer-causing potential of Nexium was assessed using studies with omeprazole in rats. Two 24-month studies looked at rats given doses of omeprazole 0.7 to 57 times a normal human dose. In these studies, rats that got omeprazole were more likely to get stomach tumors. Benign (non-cancerous) polyps or nodules of the gastrointestinal tract have been observed in people following treatment with Nexium. Nexium has been shown to be safe and effective over long periods of time to treat conditions in which the stomach makes too much acid (e.g., Zollinger-Ellison Syndrome). Long-term use of proton pump inhibitors has not been proven to cause stomach cancer in humans. New safety information has become available regarding the use of proton pump inhibitors. The safety information includes a possible increased risk of fractures of the hip, wrist and spine with the use of the medications. Studies have found that the greatest risk of fractures were in people who received high doses of proton pump inhibitors or in people who used the medications for 1 year or more. In general, the risks of taking a medication must be weighed against its health benefits. Derek Dore, PharmD
See also How to Use section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John's wort.
Some products need stomach acid so that the body can absorb them properly. Asector decreases stomach acid, so it may change how well these products work. Some affected products include atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.
Asector is very similar to omeprazole. Do not use any medications containing omeprazole while using Asector.
This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
Q: If you are taking Nexium, can you stop at any time?
A: Your question regards if you can stop taking Nexium (Asector) //www.everydayhealth.com/drugs/nexium at any time. It is recommended to talk to your health care provider before stopping any prescription medication. If you do stop taking your medication, you may start to see symptoms returning of the condition that you initially were using it to treat (i.e. GERD). As always, talk with your health care provider regarding questions about your medications. Jen Marsico, RPh
Q: Does Nexium make me gain weight?
A: Drugs can cause weight gain in several different ways. Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others. There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. These include antidepressants like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs). Mood stabilizers (lithium, valproic acid), antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications (insulin, sulfonylureas, and thiazolidinediones), antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors. Nexium (Asector) has been reported to cause weight change, which could be a gain or loss. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Laura Cable, PharmD
Dosage Forms And Strengths
NEXIUM I.V. for Injection is supplied as a freeze-dried white to off-white powder containing 20 mg or 40 mg of Asector per single-use vial.
Q: Is there a generic for Nexium 40mg?
A: Nexium (Asector) is in a drug class called proton pump inhibitors. Nexium is used to treat gastroesophageal reflux disease (GERD). Nexium is also used to prevent ulcers (sores in the lining of the stomach) in people who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). In combination with certain other medications, Nexium is used to treat and prevent the recurrence of stomach ulcers caused by H. pylori, a type of bacteria. Nexium is also used to treat conditions (e.g., Zollinger-Ellison Syndrome) in which the stomach makes too much acid. Nexium works be reducing acid production in the stomach. Generic drugs are lower-cost alternatives to more expensive brand-name drugs. They will appear different and have a few other minor differences from the brand-name drugs, but their labeling and directions for use must be virtually the same as that of the brand name product. Both brand-name and generic drug manufacturing facilities must follow the same standards of good manufacturing practices and meet the U.S. Food and Drug Administration's (FDA) specifications. The FDA also requires that generic drugs be bioequivalent to their brand-name counterparts. This means that a generic drug will work the same way in your body as the brand-name medication. Generics are considered by the FDA to be identical to brand-name drugs in dose, strength, route of administration, safety, efficacy, and intended use. Currently there is not a generic version of Nexium available. The price of a medication, like Nexium, can vary depending on the wholesaler and pharmacy from which the medication is acquired. Pharmacies sell medication to consumers at a price that includes the cost for acquiring the drug from the wholesaler, plus a retail markup. If a third-party payer (for example, a health insurance company or Medicare) is providing coverage for a medication, such as Nexium, they determine the final cost of the product. Costs will vary from one plan to another, and the payer may cover or reimburse part or all of the cost. In addition to Nexium, Aciphex (rabeprazole), Kapidex (dexlansoprazole), Nexium (Asector), Prevacid (lansoprazole), Prilosec (omeprazole), and Protonix (pantoprazole) belong to the proton pump inhibitor drug class. Studies show that, in general, proton pump inhibitors are about equally effective. Moreover, in general, there is little scientific evidence that there are any important differences in the safety of the proton pump inhibitors. As such, many third-party payers promote
Q: I am currently taking Nexium and am concerned about gaining weight. Does it cause weight gain?
A: Weight gain is not a common side effect of Nexium (Asector). According to the prescribing information for Nexium, weight gain was reported by less than 1 percent of patients in clinical trials. Consult your healthcare provider for any changes in your medical condition, including unusual weight gain. Do not stop or change the amount of medication you take without talking to your healthcare provider first. You may also find helpful information at //www.everydayhealth.com/drugs/nexium and //www.everydayhealth.com/weight/weight-management.aspx. Sarah McKenney Lewis, Pharm
Is Asector safe to take if I'm pregnant or breastfeeding?
Use of Asector in pregnant women has not been adequately evaluated.
Asector has not been adequately studied in nursing women.
What should I discuss with my healthcare provider before taking Asector?
Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.
You should not use this medicine if you are allergic to Asector or to similar medicines such as lansoprazole, omeprazole, pantoprazole, rabeprazole, Dexilant, Nexium, Prevacid, Protonix, and others.
Tell your doctor if you have ever had:
- severe liver disease;
- osteoporosis or low bone mineral density (osteopenia); or
- low levels of magnesium in your blood.
You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
Ask a doctor before using this medicine if you are pregnant or breast-feeding.
What should I avoid while taking Asector?
This medicine can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
Some studies indicate that the differences between omeprazole and Asector may offer some advantages to people with certain conditions.
An older study from 2002 found that Asector provided more effective control of GERD than omeprazole at the same doses.
According to a later study in 2009, Asector offered faster relief than omeprazole in the first week of use. After one week, symptom relief was similar.
However, in a 2007 article in American Family Physician, doctors questioned these and other studies on PPIs. They cited concerns such as:
- differences in the amount of active ingredients given in the studies
- the size of the studies
- the clinical methods used to measure effectiveness
The authors analyzed 41 studies on the effectiveness of PPIs. They concluded that there’s little difference in the effectiveness of PPIs.
So, while there’s some data to suggest that Asector is more effective at relieving symptoms, most experts agree that the PPIs have similar effects overall.
The American College of Gastroenterology states that there are no major differences in how well different PPIs work for treating GERD.
How should I take Asector?
Use exactly as directed on the label, or as prescribed by your doctor.
Asector is usually given for 4 to 8 weeks only. Your doctor may recommend a second course of treatment if you need additional healing time.
Take each dose with a full glass (8 ounces) of water.
Asector should be taken at least one hour before a meal.
Swallow the capsule whole and do not crush, chew, break, or open it.
If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away without chewing. Do not save it for later use.
The Asector capsule can be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Call your doctor if your symptoms do not improve or if they get worse while you are taking this medicine.
This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Asector.
Some conditions are treated with a combination of Asector and antibiotics. Use all medications as directed.
Store at room temperature away from moisture and heat.