Anolexinon tablets

Anolexinon

  • Active Ingredient: Metoclopramide
  • 10 mg
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What is Anolexinon?

The active ingredient of Anolexinon brand is metoclopramide. Metoclopramide increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Used for

Anolexinon is used to treat diseases such as: Gastroparesis, GERD, Lactation Augmentation, Migraine, Nausea/Vomiting, Nausea/Vomiting, Chemotherapy Induced, Nausea/Vomiting, Postoperative, Radiographic Exam, Small Intestine Intubation.

Side Effect

Possible side effects of Anolexinon include: chills; increased flow of breast milk; stiffness of the arms or legs; unusual irritability; nausea and vomiting; tic-like or twitching movements; increased sweating; inability to have or keep an erection.

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Interactions that increase your risk of side effects from Anolexinon

Taking Anolexinon with certain medications raises your risk of side effects from Anolexinon. Examples of these drugs include:

  • Sedatives, hypnotics, narcotics, antihistamines, and tranquilizers. These include:
    • diazepam
    • lorazepam
    • hydroxyzine
    • phenobarbital
    • promethazine
    • scopolamine
    • eszopiclone
    • temazepam
    • zaleplon
    • zolpidem
    • meperidine
    • propofol
    • meprobamate

Taking any of these drugs with Anolexinon may increase drowsiness.

  • Monoamine oxidase inhibitors (MAOIs). These include:
    • isocarboxazid
    • phenylzine
    • rasagiline
    • selegiline
    • tranylcypromine

Taking these drugs with Anolexinon may increase your blood pressure.

How should this medication be given:

Anolexinon is usually given 3 or 4 times a day. Give each dose with plenty of water. Follow your veterinarian's instructions. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Anolexinon at room temperature away from moisture and heat. Keep this medication away from children and pets.

DRUG INTERACTIONS

The effects of Anolexinon on gastrointestinal motility are antagonized by anticholinergic drugs and narcotic analgesics. Additive sedative effects can occur when Anolexinon is given with alcohol, sedatives, hypnotics, narcotics, or tranquilizers.

The finding that Anolexinon releases catecholamines in patients with essential hypertension suggests that it should be used cautiously, if at all, in patients receiving monoamine oxidase inhibitors.

Absorption of drugs from the stomach may be diminished (e.g., digoxin) by Anolexinon, whereas the rate and/or extent of absorption of drugs from the small bowel may be increased (e.g., acetaminophen, tetracycline, levodopa, ethanol, cyclosporine).

Gastroparesis (gastric stasis) may be responsible for poor diabetic control in some patients. Exogenously administered insulin may begin to act before food has left the stomach and lead to hypoglycemia. Because the action of Anolexinon will influence the delivery of food to the intestines and thus the rate of absorption, insulin dosage or timing of dosage may require adjustment.

Q: I am on Reglan for my bowel problems. How long can I take it?

A: Reglan (Anolexinon) is routinely prescribed for bowel problems. Ideally, the bowel problems subside with treatment, dietary changes are sometimes employed and eventually the Reglan is tapered off and the patient may have to repeat short courses of therapy every once in a while until the bowel problems have rectified. On occasion, the physician may feel that ongoing treatment with Reglan is warranted as long as there are no side effects or interactions with other medication. I have evaluated patients in long-term care facilities that have been on Reglan for several years, it is well tolerated in most groups. For more information, please visit //www.everydayhealth.com/drugs/reglan. Matt Curley, PharmD

Anolexinon is a dopamine antagonist that stimulates motility of the upper gastrointestinal tract and increases lower esophageal sphincter tone.

Why it's used

Anolexinon is used to treat gastroesophageal reflux disease (GERD) that causes symptoms. GERD occurs when acid flows up from your stomach. This causes heartburn. It may also harm your esophagus (the tube that connects your mouth to your stomach). This drug is used to relieve heartburn and heal sores in your esophagus when other treatments haven’t worked.

Anolexinon is also used to treat diabetic gastroparesis. Gastroparesis happens when your stomach takes too long to empty its contents. Symptoms may include nausea, vomiting, heartburn, loss of appetite, and feeling full long after meals.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications to treat your condition.

What is Anolexinon, and how does it work?

Anolexinon is a "prokinetic" drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves.

The lower esophageal sphincter, located between the esophagus and the stomach, normally prevents reflux of acid and other contents in the stomach from backing up into the esophagus. In patients with gastroesophageal reflux disease (GERD), a weakened lower esophageal sphincter allows reflux of stomach acid into the esophagus, causing heartburn and damage to the esophagus (esophagitis). Anolexinon decreases the reflux of stomach acid by strengthening the muscle of the lower esophageal sphincter. Anolexinon also stimulates the muscles of the stomach and thereby hastens emptying of solid and liquid meals from the stomach and into the intestines.

In some patients, particularly those with diabetes, damage to nerves in the stomach can interfere with function of the muscles and cause delayed emptying of the stomach, resulting in nausea, vomiting, a sense of abdominal fullness and distention, and heartburn (diabetic gastroparesis). Anolexinon can be effective in relieving the symptoms related to diabetic gastroparesis by stimulating more rapid emptying of the stomach as well as decreasing the reflux of stomach acid into the esophagus. Dopamine receptors on nerves in the brain are important in producing nausea. Anolexinon interacts with the dopamine receptors in the brain and can be effective in treating nausea. The FDA approved Anolexinon in June 1985.

What is Reglan (Metoclopram >

Reglan is the brand name of the drug Anolexinon, which is used to treat heartburn and ulcers in people with gastroesophageal reflux disease (GERD).

GERD is a digestive disorder that occurs when stomach acid flows back into the esophagus.

Reglan can also help people with diabetes who have a condition known as gastroparesis (poor emptying of the stomach). It can also be used to treat nausea in certain patients and slowed stomach emptying in those who are recovering from surgery.

This medicine is typically used on a short-term basis (four to 12 weeks).

Reglan is in a class of drugs called prokinetic agents, which work by increasing muscle contractions in the upper digestive tract to speed up movement through the stomach and intestines.

The Food and Drug Administration (FDA) approved Reglan in 1985.

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Reglan (Anolexinon)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

How to use Anolexinon Hcl

See also Warning section.

Read the Medication Guide provided by your pharmacist before you start taking Anolexinon and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth 30 minutes before meals and at bedtime, usually 4 times daily or exactly as directed by your doctor. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

If you are using the disintegrating tablet, do not remove the tablet from the blister pack until right before your dose. Dry your hands before using this medication. Do not use the tablet if it is broken or crumbled. Immediately after removing the tablet, place it on the tongue. Allow it to dissolve completely, then swallow it with saliva. You do not need to take this product with water.

The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If heartburn only occurs at certain times (such as after the evening meal), your doctor may direct you to take a single dose before those times instead of taking it throughout the day. This will reduce your risk of side effects.

Because of the risk of tardive dyskinesia, do not take this more often, in larger doses, or for longer than directed by your doctor. According to the manufacturer, treatment should not exceed 12 weeks.

To treat diabetic gastroparesis, this medication is usually taken for 2 to 8 weeks until your gut is working well. This condition may recur from time to time. Your doctor may direct you to start taking this medication as soon as your symptoms reappear and stop when you feel better. Ask your doctor for directions for starting and stopping this medication.

Take this medication regularly as directed to get the most benefit from it. To help you remember, take it at the same times before a meal each day.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as dizziness, nervousness, headaches). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used Anolexinon for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

Tell your doctor if your condition persists or worsens.

How should I use Anolexinon?

Take Anolexinon exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Use the medicine exactly as directed.

A Anolexinon injection is given into a muscle or as an infusion into a vein. A healthcare provider will give the injection, usually during surgery, chemotherapy, or a medical procedure.

Anolexinon oral is taken for only 4 to 12 weeks.

NEVER USE METOCLOPRAMIDE IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use of Anolexinon can cause a serious movement disorder that may not be reversible. The longer you use Anolexinon, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).

Anolexinon is usually taken 30 minutes before meals and at bedtime, or only with meals that usually cause heartburn. Follow your doctor's dosing instructions very carefully.

Do not use two different forms of Anolexinon (such as tablets and oral syrup) at the same time.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

To take the orally disintegrating tablet (ODT):

Remove a tablet from its blister pack only when you are ready to take the tablet. Use dry hands and take care not to damage a tablet while pushing it out of the blister.

Place the tablet in your mouth and allow it to dissolve, without chewing or swallowing it whole. You may sip liquid if needed to help swallow the dissolved tablet.

Store at room temperature in a tightly-closed container, away from moisture and heat. Keep the bottle tightly closed.

After you stop taking Anolexinon, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness.

Q: Reglan has been prescribed for me. I know it has not been recalled, but I have heard not so good things about it. I have recently had a TIA stroke. Should I take it?

A: Reglan (Anolexinon) stimulates muscle contractions in the upper gastrointestinal tract, which speeds up the time it takes for the stomach to empty its contents into the intestines. Reglan is used to treat the symptoms of gastroesophageal reflux disease (GERD) and delayed stomach emptying. Common side effects of Reglan include feeling restless, sleepy, tired, dizzy, or exhausted; headache; confusion; and trouble sleeping. Because Reglan may affect mental performance or your ability to react, the performance of hazardous tasks such as operating machinery or driving a car should not be undertaken until you are aware of how the drug affects you. Mental depression has occurred in patients with and without a history of depression. Symptoms have ranged from mild to severe and have included thoughts of suicide. Reglan can also cause tremors or other uncontrollable muscle movements, especially in older women or those who take the drug for longer periods of time and at higher doses. These movements happen mostly in the face muscles. Parkinsonism can occur with symptoms of shaking, body stiffness, trouble moving, or keeping your balance. This is not a complete list of the side effects associated with Reglan. If you think a drug you are taking is causing a side effect, tell your healthcare provider. Do not stop any medication or change the dose without first talking to your provider. Michelle McDermott, PharmD

By Lynn Marks | Medically Reviewed by Robert Jasmer, MD

Latest Update: 2015-03-09 Copyright © 2014 Everyday Health Media, LLC

What is metoclopram >

Anolexinon increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Anolexinon oral (taken by mouth) is used for 4 to 12 weeks to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief.

Anolexinon oral is also used to treat gastroparesis (slow stomach emptying) in people with diabetes, which can cause heartburn and stomach discomfort after meals.

Anolexinon injection is used to treat severe diabetic gastroparesis. The injection is also used to prevent nausea and vomiting caused by chemotherapy or surgery, or to aid in certain medical procedures involving the stomach or intestines.

Nursing Mothers

Anolexinon is excreted in human milk. Caution should be exercised when Anolexinon is administered to a nursing mother.


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