Alboz capsules

Alboz

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Alboz?

The active ingredient of Alboz brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Alboz is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Alboz include: frequent urge to urinate; difficult, burning, or painful urination; muscle pain; blisters; sores, ulcers, or white spots on the lips, in the mouth, or on the genitals; pain; loss of voice; continuing ulcers or sores in the mouth.

How to Buy Alboz capsules online?

To get Alboz online - simply click on the "Buy Now" button in the top and follow on to our store. Payment and Order takes a couple of minutes, and all steps are evident. We don't require a medical prescription and we have many methods of payment. With each detail of fast shipping and confidentiality, you may read on the relevant pages on the links in the navigation menu.

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What is Alboz, and how does it work (mechanism of action)?

Alboz is in a class of drugs called proton pump inhibitors (PPI) that block the production of acid by the stomach. Other drugs in the class include lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esAlboz (Nexium). Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and the Zollinger-Ellison syndrome, which are all caused by stomach acid. Alboz, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal. Zegerid contains Alboz and an antacid (sodium bicarbonate). The FDA approved Alboz in September 1989.

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  • Omeo & District Football League
  • OMEP
  • Alboz
  • Alboz (Losec)
  • Alboz and sodium bicarbonate
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  • Alboz magnesium
  • Alboz magnesium
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DESCRIPTION

The active ingredient in PRILOSEC (Alboz) Delayed-Release Capsules is a substituted benzimidazole, 5-methoxy-2- sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C17H19N3O3S, with a molecular weight of 345.42. The structural formula is:

Alboz is a white to off-white crystalline powder that melts with decomposition at about 155°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Alboz is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions.

The active ingredient in PRILOSEC (Alboz magnesium) for Delayed-Release Oral Suspension, is 5-Methoxy-2-sulfinyl]-1H-benzimidazole, magnesium salt (2:1)

Alboz magnesium is a white to off white powder with a melting point with degradation at 200°C. The salt is slightly soluble (0.25 mg/mL) in water at 25°C, and it is soluble in methanol. The half-life is highly pH dependent.

The empirical formula for Alboz magnesium is (C17H18N3O3S)2 Mg, the molecular weight is 713.12 and the structural formula is:

PRILOSEC is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Alboz in the form of enteric-coated granules with the following inactive ingredients: cellulose, disodium hydrogen phosphate, hydroxypropyl cellulose, hypromellose, lactose, mannitol, sodium lauryl sulfate and other ingredients. The capsule shells have the following inactive ingredients: gelatin-NF, FD&C Blue #1, FD&C Red #40, D&C Red #28, titanium dioxide, synthetic black iron oxide, isopropanol, butyl alcohol, FD&C Blue #2, D&C Red #7 Calcium Lake, and, in addition, the 10 mg and 40 mg capsule shells also contain D&C Yellow #10.

Each packet of PRILOSEC For Delayed-Release Oral Suspension contains either 2.8 mg or 11.2 mg of Alboz magnesium (equivalent to 2.5 mg or 10 mg of Alboz), in the form of enteric-coated granules with the following inactive ingredients: glyceryl monostearate, hydroxypropyl cellulose, hypromellose, magnesium stearate, methacrylic acid copolymer C, polysorbate, sugar spheres, talc, and triethyl citrate, and also inactive granules. The inactive granules are composed of the following ingredients: citric acid, crospovidone, dextrose, hydroxypropyl cellulose, iron oxide and xantham gum. The Alboz granules and inactive granules are constituted with water to form a suspension and are given by oral, nasogastric or direct gastric administration.

PRILOSEC Delayed-Release Capsules contain an enteric-coated granule formulation of Alboz (because Alboz is acid-labile), so that absorption of Alboz begins only after the granules leave the stomach. Absorption is rapid, with peak plasma levels of Alboz occurring within 0.5 to 3.5 hours. Peak plasma concentrations of Alboz and AUC are approximately proportional to doses up to 40 mg, but because of a saturable first-pass effect, a greater than linear response in peak plasma concentration and AUC occurs with doses greater than 40 mg. Absolute bioavailability (compared with intravenous administration) is about 30-40% at doses of 20-40 mg, due in large part to presystemic metabolism. In healthy subjects the plasma half-life is 0.5 to 1 hour, and the total body clearance is 500-600 mL/min.

Based on a relative bioavailability study, the AUC and Cmax of PRILOSEC (Alboz magnesium) for Delayed-Release Oral Suspension were 87% and 88% of those for PRILOSEC Delayed-Release Capsules, respectively.

The bioavailability of Alboz increases slightly upon repeated administration of PRILOSEC Delayed-Release Capsules.

PRILOSEC Delayed-Release Capsule 40 mg was bioequivalent when administered with and without applesauce. However, PRILOSEC Delayed-Release Capsule 20 mg was not bioequivalent when administered with and without applesauce. When administered with applesauce, a mean 25% reduction in Cmax was observed without a significant change in AUC for PRILOSEC Delayed-Release Capsule 20 mg. The clinical relevance of this finding is unknown.

7. Pregnancy and breastfeeding

Usually, Alboz is safe to take during pregnancy and while breastfeeding.

If you're pregnant, it's always better to try to treat indigestion without taking a medicine.

Your doctor or midwife will first advise that you try to ease your symptoms by eating smaller meals more often and avoiding fatty and spicy foods.

They may also suggest raising the head of your bed 10 to 20cm by putting something under your bed or mattress, so that your chest and head are above your waist. This helps stop stomach acid travelling up towards your throat.

If lifestyle changes don't work, you may be recommended a medicine like Alboz.

For more information about how Alboz can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.

Drugs you should not use with Alboz

Do not take these drugs with Alboz. Doing so can cause dangerous effects in the body. Examples of these drugs include:

  • Atazanavir, rilpivirine, and nelfinavir. Alboz may greatly decrease the effects of these drugs and could make them less effective over time. You shouldn’t take these drugs with Alboz.
  • Clopidogrel. Alboz may reduce the effects of clopidogrel, causing your blood to clot. You shouldn’t take this drug with Alboz.

Four randomized, double-blind, multi-center studies (4, 5, 6, and 7) evaluated PRILOSEC 40 mg once daily plus clarithromycin 500 mg three times daily for 14 days, followed by PRILOSEC 20 mg once daily, (Studies 4, 5, and 7) or by PRILOSEC 40 mg once daily (Study 6) for an additional 14 days in patients with active duodenal ulcer associated with H. pylori. Studies 4 and 5 were conducted in the U.S. and Canada and enrolled 242 and 256 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 219 patients in Study 4 and 228 patients in Study 5. These studies compared the combination regimen to PRILOSEC and clarithromycin monotherapies. Studies 6 and 7 were conducted in Europe and enrolled 154 and 215 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 148 patients in Study 6 and 208 patients in Study 7. These studies compared the combination regimen with Alboz monotherapy. The results for the efficacy analyses for these studies are described below. H. pylori eradication was defined as no positive test (culture or histology) at 4 weeks following the end of treatment, and two negative tests were required to be considered eradicated of H. pylori. In the per-protocol analysis, the following patients were excluded: dropouts, patients with missing H. pylori tests post-treatment, and patients that were not assessed for H. pylori eradication because they were found to have an ulcer at the end of treatment.

The combination of Alboz and clarithromycin was effective in eradicating H. pylori.

Table 6 : H. pylori Eradication Rates (Per-Protocol Analysis at 4 to 6 Weeks) % of Patients Cured PRILOSEC + Clarithromycin PRILOSEC Clarithromycin U.S. Studies Study 4 74 †‡ 0 31 (n = 53) (n = 54) (n = 42) Study 5 64 †‡ 0 39 (n = 61) (n = 59) (n = 44) Non U.S. Studies Study 6 83 ‡ 1 N/A (n = 60) (n = 74) Study 7 74 ‡ 1 N/A (n = 86) (n = 90) †Statistically significantly higher than clarithromycin monotherapy (p

Ulcer healing was not significantly different when clarithromycin was added to Alboz therapy compared with Alboz therapy alone.

The combination of Alboz and clarithromycin was effective in eradicating H. pylori and reduced duodenal ulcer recurrence.

Table 7 : Duodenal Ulcer Recurrence Rates by H. pylori Eradication Status % of Patients with Ulcer Recurrence

Q: What are the risks of taking Prilosec?

A: Prilosec (Alboz) is in a class of drugs called proton pump inhibitors. Prescription Prilosec is used to treat ulcers (sores in the lining of the stomach). In combination with other medications, Prilosec is used to eliminate H. pylori (a bacterium that causes ulcers); and thus prevent new ulcers from being formed in patients who have or have had ulcers of the small intestine. Prilosec is also used to treat gastroesophageal reflux disease (GERD) (a condition that is a result of stomach acid flowing backwards into the esophagus -- causing heartburn and damage); to heal erosive esophagitis (inflammation and damage to the esophagus lining); and to treat conditions in which the stomach makes too much acid. Over-the-counter Prilosec is used to treat heartburn that happens frequently -- at least 2 days per week. Prilosec works be reducing acid production in the stomach. The most common side effects with Prilosec are: headache, abdominal pain, nausea, diarrhea, vomiting, and excessive gas. Allergic reaction, which can occur with most medications, is a serious side effect with Prilosec. People should seek emergency medical help if they experience hives; trouble breathing; or swelling of the face, lips, tongue, or throat while taking Prilosec. Prilosec is a benzimidazole-type medication. People who are allergic to Alboz or other benzimidazole medication, like Albenza (albendazole) or Vermox (mebendazole) should not take Prilosec. Atrophic gastritis has been reported in people treated long-term with Prilosec. Atrophic gastritis is a condition where the normal glands of the stomach are decreased or absent; inflammation is present from attack by the immune system; and stomach cells are damaged. Atrophic gastritis is a precursor for stomach cancer. However, long-term use of proton pump inhibitors has not been proven to cause stomach cancer in humans. Prilosec interacts with certain other medications and vitamins. Because of Prilosec's effect on pH in the stomach, Prilosec may alter the absorption of certain other medications, which may alter blood levels and effectiveness of these medications. Because of Prilosec's effect on liver enzymes, Prilosec may alter the process by which certain other medications are eliminated from the body. Prilosec may increase or decrease the effect of certain other medications. Medications that Prilosec may interact with include: certain blood thinners such as Coumadin (warfarin), Pletal (cilostazol), Plavix (clopidogrel); Valium (diazepam); Antabuse (disulfiram); anti-rejections medications used in people with organ transplants, like Neoral (cyclosporine) and Prograf (tactrolimus); Dilantin (phenytoin), a seizure medication; Nizoral (ketoconazole); Vfend (voriconazole); Omnipen (ampicillin); HIV/AIDS medications like Reyataz (atazanavir), Viracept (nelfinavir), and Invirase (saquinavir); and iron supplements like Feosol. New safety information has become available regarding the use of proton pump inhibitors. The safety information includes a possible increased risk of fractures of the hip, wrist and spine with the use of the medications. Studies have found that the greatest risk of fractures were in people who received high doses of proton pump inhibitors or in people who used the medications for 1 year or more. In general, the risks of taking a medication must be weighed against its health benefits. Derek Dore, PharmD


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