Adprazole capsules

Adprazole

  • Active Ingredient: Omeprazole
  • 40 mg, 20 mg, 10 mg
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What is Adprazole?

The active ingredient of Adprazole brand is omeprazole. Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprazole, USP is a white to off-white crystalline powder that melts with decomposition at about 155В°C. It is a weak base, freely soluble in ethanol and methanol, and slightly soluble in acetone and isopropanol and very slightly soluble in water. The stability of Omeprazole is a function of pH; it is rapidly degraded in acid media, but has acceptable stability under alkaline conditions. Omeprazole is supplied as delayed-release capsules for oral administration. Each delayed-release capsule contains either 10 mg, 20 mg or 40 mg of Omeprazole in the form of enteric-coated beads with the following inactive ingredients: ammonium hydroxide, dibutyl sebacate, D&C Yellow No. 10, FD&C Green No. 3, gelatin, ethylcellulose, fumed silica, hypromellose, methacrylic acid, oleic acid, silicon dioxide, sodium lauryl sulfate, sugar spheres, talc, titanium dioxide and triethyl citrate. The 40 mg empty gelatin capsule shell also contains FD&C Blue No. 1. In addition, the white imprinting ink contains ammonium hydroxide, propylene glycol, shellac glaze, simethicone and titanium dioxide. Meets USP Dissolution Test 2.

Used for

Adprazole is used to treat diseases such as: Barrett's Esophagus, Duodenal Ulcer, Erosive Esophagitis, Gastritis/Duodenitis, GERD, Helicobacter Pylori Infection, Indigestion, Multiple Endocrine Adenomas, Stomach Ulcer, Systemic Mastocytosis, Zollinger-Ellison Syndrome.

Side Effect

Possible side effects of Adprazole include: sore throat; muscle spasms (tetany) or twitching seizures; Blurred vision; skin rash or itching; red or irritated eyes; chills.

How to Buy Adprazole capsules online?

To buy Adprazole online - simply click on the "Buy Now" button from the top and follow on to our shop. Order and payment takes a few minutes, and all measures are obvious. We don't take a medical prescription and also we have many procedures of payment. Considering each detail of fast shipping and confidentiality, then you may read on the applicable pages on the hyperlinks from the navigation menu.

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1. About Adprazole

Adprazole reduces the amount of acid your stomach makes. It's a widely used treatment for indigestion and heartburn and acid reflux. It's also taken to prevent and treat stomach ulcers.

Sometimes Adprazole is taken for a rare illness caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.

Adprazole comes as capsules, tablets and as a liquid that you swallow (this is made to order).

All types of Adprazole are available on prescription. You can buy the lowest strength 10mg tablets and capsules from pharmacies.

Q: Is there a substitute drug for Prilosec that is as effective, but cheaper?

A: Prilosec does have a generic equivalent, Adprazole, which you may also want to inquire about. First, you may want to contact your insurance company, prior to speaking with your doctor, and request a formulary. A formulary is a list of the medications they prefer and the different levels of coverage specific to your plan. Then it is i mportant to contact your health care provider and based on your individual needs and the formulary list of covered medications, determine the best treatment option. For more information regarding Prilosec or Adprazole, visit //www.everydayhealth.com/drugs/prilosec Beth Isaac, PharmD

Forms and strengths

Generic: Adprazole

  • Form: delayed-release oral capsule
  • Strengths: 10 mg, 20 mg, 40 mg

Four randomized, double-blind, multi-center studies (4, 5, 6, and 7) evaluated PRILOSEC 40 mg once daily plus clarithromycin 500 mg three times daily for 14 days, followed by PRILOSEC 20 mg once daily, (Studies 4, 5, and 7) or by PRILOSEC 40 mg once daily (Study 6) for an additional 14 days in patients with active duodenal ulcer associated with H. pylori. Studies 4 and 5 were conducted in the U.S. and Canada and enrolled 242 and 256 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 219 patients in Study 4 and 228 patients in Study 5. These studies compared the combination regimen to PRILOSEC and clarithromycin monotherapies. Studies 6 and 7 were conducted in Europe and enrolled 154 and 215 patients, respectively. H. pylori infection and duodenal ulcer were confirmed in 148 patients in Study 6 and 208 patients in Study 7. These studies compared the combination regimen with Adprazole monotherapy. The results for the efficacy analyses for these studies are described below. H. pylori eradication was defined as no positive test (culture or histology) at 4 weeks following the end of treatment, and two negative tests were required to be considered eradicated of H. pylori. In the per-protocol analysis, the following patients were excluded: dropouts, patients with missing H. pylori tests post-treatment, and patients that were not assessed for H. pylori eradication because they were found to have an ulcer at the end of treatment.

The combination of Adprazole and clarithromycin was effective in eradicating H. pylori.

Table 6 : H. pylori Eradication Rates (Per-Protocol Analysis at 4 to 6 Weeks) % of Patients Cured PRILOSEC + Clarithromycin PRILOSEC Clarithromycin U.S. Studies Study 4 74 †‡ 0 31 (n = 53) (n = 54) (n = 42) Study 5 64 †‡ 0 39 (n = 61) (n = 59) (n = 44) Non U.S. Studies Study 6 83 ‡ 1 N/A (n = 60) (n = 74) Study 7 74 ‡ 1 N/A (n = 86) (n = 90) †Statistically significantly higher than clarithromycin monotherapy (p

Ulcer healing was not significantly different when clarithromycin was added to Adprazole therapy compared with Adprazole therapy alone.

The combination of Adprazole and clarithromycin was effective in eradicating H. pylori and reduced duodenal ulcer recurrence.

Table 7 : Duodenal Ulcer Recurrence Rates by H. pylori Eradication Status % of Patients with Ulcer Recurrence

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people.

Call a doctor straight away if you have:

  • joint pain along with a red skin rash, especially in parts of your body exposed to the sun, such as your arms, cheeks and nose - these can be signs of a rare condition called subacute cutaneous lupus erythematosus. This can happen even if you have been taking Adprazole for a long time
  • yellow skin, dark pee and tiredness - these can be signs of liver problems

Reproductive Toxicology Studies

Reproductive studies conducted with Adprazole in rats at oral doses up to 138 mg/kg/day (about 34 times the human dose of 40 mg/day on a body surface area basis) and in rabbits at doses up to 69 mg/kg/day (about 34 times the human dose on a body surface area basis) did not disclose any evidence for a teratogenic potential of Adprazole. In rabbits, Adprazole in a dose range of 6.9 to 69.1 mg/kg/day (about 3.4 to 34 times the human dose of 40 mg/day on a body surface area basis) produced dose-related increases in embryo-lethality, fetal resorptions, and pregnancy disruptions. In rats, dose-related embryo/fetal toxicity and postnatal developmental toxicity were observed in offspring resulting from parents treated with Adprazole at 13.8 to 138.0 mg/kg/day (about 3.4 to 34 times the human dose of 40 mg/day on a body surface area basis) .

Juvenile Animal Study

A 28-day toxicity study with a 14-day recovery phase was conducted in juvenile rats with esAdprazole magnesium at doses of 70 to 280 mg /kg/day (about 17 to 68 times a daily oral human dose of 40 mg on a body surface area basis). An increase in the number of deaths at the high dose of 280 mg/kg/day was observed when juvenile rats were administered esAdprazole magnesium from postnatal day 7 through postnatal day 35. In addition, doses equal to or greater than 140 mg/kg/day (about 34 times a daily oral human dose of 40 mg on a body surface area basis), produced treatment-related decreases in body weight (approximately 14%) and body weight gain, decreases in femur weight and femur length, and affected overall growth. Comparable findings described above have also been observed in this study with another esAdprazole salt, esAdprazole strontium, at equimolar doses of esAdprazole.

Adprazole oral capsule is a prescription drug that’s only available in a generic form. It doesn’t have a brand-name version. Adprazole is also available as an oral suspension and comes as an over-the-counter (OTC) medication.

Prescription Adprazole oral capsule is a delayed-release drug. A delayed-release drug slows the release of the medication until it passes through your stomach. This delay keeps the drug from being inactivated by your stomach.

Liquid Adprazole

Liquid Adprazole can be prescribed by a doctor and made to order for children and people who cannot swallow capsules or tablets.

It'll come with a syringe or spoon to help you take the right amount. If you don't have a syringe or spoon, ask your pharmacist for one.

Do not use a kitchen teaspoon as it will not give the right amount.

The effectiveness of PRILOSEC for the treatment of nonerosive GERD in pediatric patients 1 to 16 years of age is based in part on data obtained from 125 pediatric patients in two uncontrolled Phase III studies .

The first study enrolled 12 pediatric patients 1 to 2 years of age with a history of clinically diagnosed GERD. Patients were administered a single dose of Adprazole (0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg) for 8 weeks as an open capsule in 8.4% sodium bicarbonate solution. Seventy-five percent (9/12) of the patients had vomiting/regurgitation episodes decreased from baseline by at least 50%.

The second study enrolled 113 pediatric patients 2 to 16 years of age with a history of symptoms suggestive of nonerosive GERD. Patients were administered a single dose of Adprazole (10 mg or 20 mg, based on body weight) for 4 weeks either as an intact capsule or as an open capsule in applesauce. Successful response was defined as no moderate or severe episodes of either pain-related symptoms or vomiting/regurgitation during the last 4 days of treatment. Results showed success rates of 60% (9/15; 10 mg Adprazole) and 59% (58/98; 20 mg Adprazole), respectively.

Interference With Antiretroviral Therapy

Concomitant use of atazanavir and nelfinavir with proton pump inhibitors is not recommended. Co-administration of atazanavir with proton pump inhibitors is expected to substantially decrease atazanavir plasma concentrations and may result in a loss of therapeutic effect and the development of drug resistance. Co-administration of saquinavir with proton pump inhibitors is expected to increase saquinavir concentrations, which may increase toxicity and require dose reduction.

Adprazole has been reported to interact with some antiretroviral drugs. The clinical importance and the mechanisms behind these interactions are not always known. Increased gastric pH during Adprazole treatment may change the absorption of the antiretroviral drug. Other possible interaction mechanisms are via CYP2C19.

Variables that influence Adprazole side effects

There are many variables that could influence the side effects and/or adverse reactions that a person experiences while taking Adprazole. Variables that likely influence the specific side effects that occur while taking Adprazole (and the severities of those side effects) include: dosage of Adprazole; duration of Adprazole use; concurrent substance use; and user-specific factors (e.g. medical status, genetics, lifestyle).

Interactions With Diagnostic Investigations For Neuroendocrine Tumors

Serum chromogranin A (CgA) levels increase secondary to drug-induced decreases in gastric acidity. The increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumors. Healthcare providers should temporarily stop Adprazole treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are high. If serial tests are performed (e.g. for monitoring), the same commercial laboratory should be used for testing, as reference ranges between tests may vary.

That fire in your chest might be the least of your problems.

Raise your hand if you want to physically rip your throat out of your neck after eating a spicy meal—or, honestly, after eating anything at all. I feel you; heartburn is no joke. Luckily, there's a drug for that: Adprazole.

Omepra-what? You've probably heard of it as Prilosec or Zegerid—it's one of the most popular treatments for chronic heartburn. You can buy it over the counter any time you're having after-dinner indigestion, or if you've got a serious case of the burn, your doctor can prescribe you a stronger dosage.

The medicine's a type of drug called a "proton-pump inhibitor." Adprazole works by blocking gastric acid secretion in your stomach which reduces heartburn, says Shilpa Ravella, M.D., a gastroenterologist and assistant professor of medicine at Columbia University Medical Center.

It can also be used to treat ulcers and to help patients with tumors that result in high levels of gastric acid secretion, she adds. Adprazole can be used for a short period like a few weeks, or for a longer time, including lifetime use.

But whether you're just popping an OTC pill to help you get through a rough patch or you need to stay on it long-term, there are some side effects of Adprazole you should definitely know about.

Gastric Ulcer

In a U.S. multicenter, double-blind, study of Adprazole 40 mg once daily, 20 mg once daily, and placebo in 520 patients with endoscopically diagnosed gastric ulcer, the following results were obtained.

Treatment of Gastric Ulcer % of Patients Healed (All Patients Treated) PRILOSEC 20 mg once daily (n = 202) PRILOSEC 40 mg once daily (n = 214) Placebo (n = 104) Week 4 47 5** 55.6** 30.8 Week 8 74.8** 82.7**,+ 48.1 **(p + (p

For the stratified groups of patients with ulcer size less than or equal to 1 cm, no difference in healing rates between 40 mg and 20 mg was detected at either 4 or 8 weeks. For patients with ulcer size greater than 1 cm, 40 mg was significantly more effective than 20 mg at 8 weeks.

In a foreign, multinational, double-blind study of 602 patients with endoscopically diagnosed gastric ulcer, Adprazole 40 mg once daily, 20 mg once daily, and ranitidine 150 mg twice a day were evaluated.

Treatment of Gastric Ulcer % of Patients Healed (All Patients Treated) PRILOSEC 20 mg once daily (n = 200) PRILOSEC 40 mg once daily (n = 187) Ranitidine 150 mg twice daily (n = 199) Week 4 63.5 78.1**,++ 56.3 Week 8 81.5 91.4**,++ 78.4 ** (p


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