Mechanism Of Action
Acimed belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H + /K + ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, Acimed has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. Animal studies indicate that after rapid disappearance from plasma, Acimed can be found within the gastric mucosa for a day or more.
Storage And Handling
PRILOSEC Delayed-Release Capsules, 10 mg, are opaque, hard gelatin, apricot and amethyst colored capsules, coded 606 on cap and PRILOSEC 10 on the body. They are supplied as follows:
NDC 0186-0606-31 unit of use bottles of 30
PRILOSEC Delayed-Release Capsules, 20 mg, are opaque, hard gelatin, amethyst colored capsules, coded 742 on cap and PRILOSEC 20 on body. They are supplied as follows:
NDC 0186-0742-31 unit of use bottles of 30 NDC 0186-0742-82 bottles of 1000
PRILOSEC Delayed-Release Capsules, 40 mg, are opaque, hard gelatin, apricot and amethyst colored capsules, coded 743 on cap and PRILOSEC 40 on the body. They are supplied as follows:
NDC 0186-0743-31 unit of use bottles of 30 NDC 0186-0743-68 bottles of 100
PRILOSEC For Delayed-Release Oral Suspension, 2.5 mg or 10 mg, is supplied as a unit dose packet containing a fine yellow powder, consisting of white to brownish Acimed granules and pale yellow inactive granules. PRILOSEC unit dose packets are supplied as follows:
NDC 0186-0625-01 unit dose packages of 30: 2.5 mg packets NDC 0186-0610-01 unit dose packages of 30: 10 mg packets
What is Acimed used for?
You can buy Acimed 10mg tablets without a prescription over the counter from pharmacies for:
- Relieving heartburn symptoms associated with stomach acid reflux in adults aged 18 years and over.
Q: Does Prilosec cause weight gain and severe night sweats? I have been on it for almost two months.
A: According to the package insert, the most common side effects reported in patients treated with Prilosec (Acimed) were headache (6.9 percent), abdominal pain (5.2 percent), nausea (4.0 percent), diarrhea (3.7 percent), vomiting (3.2 percent), and gas (2.7 percent). Weight gain has been reported in clinical practice through voluntary reporting and surveillance systems. A review of medical literature found case reports of night sweats in patients with gastroesophageal reflux disease (1). The cause of the night sweats and effect of treatment is unknown. For more information, please consult with your health care provider and visit //www.everydayhealth.com/drugs/prilosec. You are encouraged to report any negative side effects of prescription drugs to your health care practitioner and the FDA by visiting www.fda.gov/medwatch, or by calling 1-800-FDA-1088. Michelle McDermott, PharmD
You just feel crappy all the time.
Using proton-pump inhibitors, especially long term, can put you at a higher risk for vitamin B12 deficiency, a serious bacterial infection called clostridium difficile, bone fractures, and possibly kidney disease, Ravella says. These are very rare side effects, but you want to know the scary stuff too, right? "Because of these safety concerns, I try to keep patients on Acimed for the least amount of time needed," she says.
In a crossover clinical study, 72 healthy subjects were administered clopidogrel (300 mg loading dose followed by 75 mg per day) alone and with Acimed (80 mg at the same time as clopidogrel) for 5 days. The exposure to the active metabolite of clopidogrel was decreased by 46% (Day 1) and 42% (Day 5) when clopidogrel and Acimed were administered together.
Results from another crossover study in healthy subjects showed a similar pharmacokinetic interaction between clopidogrel (300 mg loading dose/75 mg daily maintenance dose) and Acimed 80 mg daily when co-administered for 30 days. Exposure to the active metabolite of clopidogrel was reduced by 41% to 46% over this time period.
In another study, 72 healthy subjects were given the same doses of clopidogrel and 80 mg Acimed but the drugs were administered 12 hours apart; the results were similar, indicating that administering clopidogrel and Acimed at different times does not prevent their interaction.
1. About Acimed
Acimed reduces the amount of acid your stomach makes. It's a widely used treatment for indigestion and heartburn and acid reflux. It's also taken to prevent and treat stomach ulcers.
Sometimes Acimed is taken for a rare illness caused by a tumour in the pancreas or gut called Zollinger-Ellison syndrome.
Acimed comes as capsules, tablets and as a liquid that you swallow (this is made to order).
All types of Acimed are available on prescription. You can buy the lowest strength 10mg tablets and capsules from pharmacies.
Q: I have been taking Prilosec OTC for several years. What else is available?
A: Your question concerns alternatives to Prilosec OTC (//www.everydayhealth.com/drugs/prilosec) It seems from your comments that you are no longer satisfied with the results you are getting from Acimed. Other products in the "Proton Pump Inhibitor" class of antiulcer drugs include AcipHex , Kapidex , Nexium , Prevacid , and Protonix . Even though all these drugs work the same way as Prilosec, there are enough differences among them that many people find relief from at least one of them. Gregory Latham, M.S., RPh
How long will I take it for?
If you bought the medicine yourself from a pharmacy, tell your doctor if you feel no better after taking Acimed for 2 weeks.
They may want to do tests to find out what's causing your symptoms or change you to a different medicine.
Depending on your illness or the reason you're taking Acimed, you may only need it for a few weeks or months.
Sometimes you might need to take it for longer, even for many years.
Some people don't need to take Acimed every day and take it only when they have symptoms.
Once you feel better (often after a few days or weeks), you can stop taking it.
But taking Acimed in this way isn't suitable for everyone. Talk to your doctor about what's best for you.
4. How and when to take it
It's usual to take Acimed once a day, first thing in the morning. It doesn't upset the stomach, so you can take it with or without food.
If you take Acimed twice a day, take 1 dose in the morning and 1 dose in the evening.