Sintecal tablets


  • Active Ingredient: Glimepiride
  • 4 mg, 2 mg, 1 mg
Buy Now

What is Sintecal?

The active ingredient of Sintecal brand is glimepiride. Glimepiride is an oral diabetes medicine that helps control blood sugar levels. Glimepiride tablets contain the active ingredient Glimepiride and the following inactive ingredients:lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate (potato). In addition, the 2 mgand 4 mg tablets contain D&C Yellow No. 10 Aluminum Lake and the 4 mg also contains D&C Red No. 27 Aluminum Lake.

Used for

Sintecal is used to treat diseases such as: Diabetes, Type 2.

Side Effect

Possible side effects of Sintecal include: confusion; dark urine; Anxiety; red, irritated eyes; fluid-filled skin blisters; shortness of breath; Abdominal or stomach pain; upper right abdominal or stomach pain.

How to Buy Sintecal tablets online?

To buy Sintecal online - simply click on the "Buy Now" button in the top and follow along with our store. Payment and Order takes a few minutes, and all measures are evident. We do not require a medical prescription and also we have many methods of payment. With all the details of fast delivery and confidentiality, you can read on the applicable pages on the hyperlinks in the top menu.

Related Medications


Prosan 50mg, 25mg


More info


Glifortex 850mg, 500mg


More info


Loctenk 50mg, 25mg


More info


Losatrix 50mg, 25mg


More info

Concomitant Administration of Colesevelam

Colesevelam can reduce the maximum plasma concentration and total exposure of Sintecal when the two are coadministered. However, absorption is not reduced when Sintecal is administered 4 hours prior to colesevelam. Therefore, Sintecal should be administered at least 4 hours prior to colesevelam.

Quinolone antibiotics

These drugs can increase the effect of Sintecal and cause low blood sugar. Examples of these drugs include:

  • ciprofloxacin (Cipro)
  • levofloxacin (Levaquin)

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Sintecal overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

Which drugs or supplements interact with Sintecal?

  • Some medications when given with Sintecal may reduce its ability to lower blood sugar. These drugs include diuretics, for example, hydrochlorothiazide (Microzide, and many combinations with other drugs), loop diuretics (for example, furosemide ), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), colesevelam (Welchol), danazol and somatropin (Genotropin). Rifampin increases the breakdown of Sintecal by liver enzymes. This might reduce the effect of Sintecal and result in higher levels of sugar in the blood.
  • Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar. Additionally, they can directly reverse the sugar-lowering effect of sulfonylureas and render them less effective. Beta blockers also can blunt some of the body's protective responses to low blood sugar, thus making it difficult for patients to recognize reactions due to low blood sugar (hypoglycemia).
  • Certain drugs when given with Sintecal may increase the risk of low blood sugar (hypoglycemia). These include nonsteroidal anti-inflammatory drugs or NSAIDs (for example ibuprofen), sulfa drugs, warfarin (Coumadin), miconazole (Oravig), fluconazole (Diflucan), chloramphenicol, cimetidine (Tagamet HB), ranitidine (Zantac), clarithromycin (Biaxin), MAO Inhibitors (for example, isocarboxazid and phenelzine ), mifepristone (Mifeprex), probenecid, quinolone antibiotics and selective serotonin reuptake inhibitors or SSRIs (for example paroxetine , fluoxetine and sertraline ) and voriconazole (Vfend). Blood sugar should be closely monitored when interacting drugs are given with Sintecal.
  • Combination Sintecal with insulin and use in patients with congestive heart failure may increase risk of other heart related side effects.


Available data from a small number of published studies and postmarketing experience with Glimepir >Clinical Considerations). Poorly controlled diabetes in pregnancy is also associated with risks to the mother and fetus (see Clinical Considerations ). In animal studies (see Data) , there were no effects on embryo-fetal development following administration of Sintecal to pregnant rats and rabbits at oral doses approximately 4,000 times and 60 times the maximum human dose based on body surface area, respectively. However, fetotoxicity was observed in rats and rabbits at doses 50 times and 0.1 times the maximum human dose, respectively.

The estimated background risk of major birth defects is 6% to 10% in women with pregestational diabetes with a HbA1c >7% and has been reported to be as high as 20% to 25% in women with a HbA1c >10%. The estimated background risk of miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively.

Disease-associated maternal and/or embryo-fetal risk

Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery, and delivery complications. Poorly controlled diabetes increases the fetal risk for major birth defects, still birth, and macrosomia-related morbidity.

Fetal/neonatal adverse reactions

Neonates of women with gestational diabetes who are treated with sulfonylureas during pregnancy may be at increased risk for neonatal intensive care admission and may develop respiratory distress, hypoglycemia, birth injury, and be large for gestational age. Prolonged severe hypoglycemia, lasting 4 to 10 days, has been reported in neonates born to mothers receiving a sulfonylurea at the time of delivery and has been reported with the use of agents with a prolonged half-life. Observe newborns for symptoms of hypoglycemia and respiratory distress and manage accordingly.

Dose adjustments during pregnancy and the postpartum period

Due to reports of prolonged severe hypoglycemia in neonates born to mothers receiving a sulfonylurea at the time of delivery, Glimepir >Fetal/Neonatal Adverse Reactions ).

In animal studies, there was no increase in congenital anomalies, but an increase in fetal deaths occurred in rats and rabbits at Sintecal doses 50 times (rats) and 0.1 times (rabbits) the maximum recommended human dose (based on body surface area). This fetotoxicity was observed only at doses inducing maternal hypoglycemia and is believed to be directly related to the pharmacologic (hypoglycemic) action of Sintecal, as has been similarly noted with other sulfonylureas.

Hemolytic Anemia

Sulfonylureas can cause hemolytic anemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Because Sintecal tablets are a sulfonylurea, use caution in patients with G6PD deficiency and consider the use of a non-sulfonylurea alternative.

There are also postmarketing reports of hemolytic anemia in patients receiving Glimepir >Adverse Reactions ( 6.2 ) ].

Conversion from other oral hypoglycemic agents

  • Observe patients carefully for 1-2 weeks when being converted from long half-life sulfonylureas to Sintecal, because of potential for overlapping of hypoglycemic effects

What is Sintecal (Amaryl)?

Sintecal is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Sintecal may also be used for purposes not listed in this medication guide.

Blood pressure and heart drugs (angiotensin-converting enzyme inhibitors)

These drugs can increase the effect of Sintecal and cause low blood sugar. Examples of these drugs include:

  • benazepril (Lotensin)
  • captopril (Capoten)
  • enalapril (Vasotec)
  • enalaprilat
  • fosinopril (Monopril)
  • lisinopril (Prinivil)
  • moexipril (Univasc)
  • perindopril (Aceon)
  • quinapril (Accupril)
  • ramipril (Altace)
  • trandolapril (Mavik)

Where can I get more information (Amaryl)?

Your pharmacist can provide more information about Sintecal.

© Copyright 2017-2020 - - We Care About You!