What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Bone pain.
- Feeling very tired or weak.
- Change in eyesight.
- Pain when passing urine or blood in urine.
- Passing urine more often.
- Low blood sugar can happen. The chance may be raised when Piolit is used with other drugs for diabetes. Signs may be dizziness, headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow what you have been told to do for low blood sugar. This may include taking glucose tablets, liquid glucose, or some fruit juices.
- Very bad and sometimes deadly liver problems have happened with Piolit. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
8. Cautions with other medicines
Some medicines interfere with the way Piolit works. Your doctor may need to adjust your dose of Piolit. They may also recommend checking your blood sugar levels more often.
Tell your doctor if you're taking any of these medicines before starting on Piolit:
- gemfibrozil, a medicine used to reduce cholesterol
- rifampicin, a medicine for treating tuberculosis
Oral route (Tablet)
Piolit hydrochloride may cause or worsen congestive heart failure. Monitor patients for signs and symptoms of heart failure after initiation or dose increases. Should such signs and symptoms of congestive heart failure develop, manage according to current standards of care and consider discontinuing therapy or a dose reduction. Piolit hydrochloride is not recommended in patients with symptomatic heart failure and is contraindicated in patients with established NYHA Class III or IV heart failure.
Along with its needed effects, Piolit may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking Piolit:
- Chest pain
- decreased urine output
- dilated neck veins
- extreme fatigue
- irregular breathing
- irregular heartbeat
- problems with teeth
- swelling of the face, fingers, feet, or lower legs
- tightness in the chest
- trouble breathing
- weight gain
- Pain or swelling in the arms or legs without an injury
- pale skin
- trouble with breathing when active
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence not known
- Dark urine
- loss of appetite
- nausea or vomiting
- stomach pain
- unexplained, rapid weight gain
- yellow eyes or skin
Some side effects of Piolit may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Blurred vision or other changes in vision
- dry mouth
- flushed, dry skin
- fruit-like breath odor
- increased hunger
- increased thirst
- increased urination
- loss of consciousness
- muscle pain or soreness
- problems with your teeth
- runny or stuffy nose
- sore throat
- unexplained weight loss
What if I forget to take it?
If you forget to take your Piolit, skip the missed dose and take your next dose at the usual time.
Do not take a double dose to make up for a forgotten one.
If you forget doses often, it may help to set an alarm to remind you. You could ask your pharmacist for advice on other ways to remember your medicines.
Like all medicines, Piolit can cause side effects, although not everyone gets them.
Piolit and Alcohol
Alcohol can cause your blood-sugar levels to decrease.
Ask your doctor if it's safe for you to consume alcoholic beverages while taking Piolit.
Urgent advice: Contact your doctor straight away if you take too much Piolit
If you take Piolit with other diabetes medicines, taking too many tablets may cause low blood sugar.
If you think you have low blood sugar, have some food or drink that quickly gets sugar into your bloodstream such as sugar cubes or fruit juice. This type of sugar won't last long in your blood. You may also need to eat a starchy carbohydrate, like a sandwich or some biscuits.
Why is Actos (Piolit) prescribed to patients?
- Actos is used for the treatment of type 2 diabetes in adults. It is used along with a healthy diabetic diet, regular exercise, weight control, smoking reduction, and careful monitoring of blood glucose.
- Actos may be used alone or in combination with metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet), a drug in a different class of anti-diabetic drugs, that also lowers blood glucose.
- Actos requires naturally-secreted insulin to be effective so it is not recommended in type 1 diabetes where the amount of insulin is very low or absent.
- Nevertheless, Actos is approved for treating type 2 diabetes in combination with insulin as well as another class of diabetes drugs, the sulfonylureas, that increases the amount of insulin produced.