Melizide tablets

Melizide

  • Active Ingredient: Glipizide
  • 10 mg
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What is Melizide?

The active ingredient of Melizide brand is glipizide. Glipizide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin. Glipizide, USP is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 N NaOH; it is freely soluble in dimethylformamide. Glipizide tablets for oral use are available in 5 mg and 10 mg strengths. Inert ingredients are: colloidal silicon dioxide, lactose (anhydrous), microcrystalline cellulose, pregelatinized starch (corn) and stearic acid.

Used for

Melizide is used to treat diseases such as: Diabetes, Type 2.

Side Effect

Possible side effects of Melizide include: trouble sleeping; unusual tiredness or weakness; Acid or sour stomach; dizziness; severe stomach pain.

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Which drugs or supplements interact with Melizide?

  • Alcohol may prolong the action of Melizide by delaying the absorption and elimination of Melizide. Patients taking Melizide should keep alcohol consumption to a minimum.
  • Cholestyramine (Questran, Questran Light) may reduce both the absorption and effects of Melizide. Melizide should therefore be administered 1-2 hours before cholestyramine is given.
  • Fluconazole (Diflucan) also can increase the absorption and effects of Melizide.
  • nonsteroidal anti-inflammatory drugs (for example ),
  • sulfa drugs,
  • warfarin (Coumadin),
  • miconazole (Oravig),
  • fluconazole (Diflucan),
  • voriconazole (Vfend),
  • beta-blockers (for example, propranolol ),
  • androgens (for example fluoxymesterone ),
  • chloramphenicol,
  • cimetidine (Tagamet HB),
  • ranitidine (Zantac),
  • clarithromycin (Biaxin),
  • MAO Inhibitors (for example, isocarboxazid and phenelzine ),
  • mifepristone (Mifeprex),
  • probenecid,
  • quinolone antibiotics, and
  • selective serotonin reuptake inhibitors (for example paroxetine , fluoxetine , and sertraline .
  • thiazide diuretics (for example, hydrochlorothiazide ),
  • loop diuretics (for example, furosemide ),
  • corticosteroids such as prednisone and methylprednisolone (Medrol),
  • phenytoin (Dilantin),
  • colesevelam (Welchol),
  • danazol and somatropin (Genotropin).
  • Rifampin may reduce the blood levels of Melizide and this may result in higher levels of sugar in the blood.
  • Patients Receiving Other Oral Hypoglycemic Agents

    As with other sulfonylurea-class hypoglycemics, no transition period is necessary when transferring patients to GLUCOTROL. Patients should be observed carefully (1–2 weeks) for hypoglycemia when being transferred from longer half-life sulfonylureas (e.g., chlorpropamide) to GLUCOTROL due to potential overlapping of drug effect.

    When colesevelam is coadministered with Melizide ER, maximum plasma concentration and total exposure to Melizide is reduced. Therefore, GLUCOTROL should be administered at least 4 hours prior to colesevelam.

    Metaglip (Melizide and metformin)

    In a double-blind 24-week clinical trial involving METAGLIP (Melizide and metformin) as initial therapy, a total of 172 patients received METAGLIP (Melizide and metformin) 2.5 mg/250 mg, 173 received METAGLIP (Melizide and metformin) 2.5 mg/500 mg, 170 received Melizide, and 177 received metformin. The most common clinical adverse events in these treatment groups are listed in Table 4.

    Table 4: Clinical Adverse Events > 5% in any Treatment Group, by Primary Term, in Initial Therapy Study

    In a double-blind 18-week clinical trial involving METAGLIP (Melizide and metformin) as second-line therapy, a total of 87 patients received METAGLIP (Melizide and metformin) , 84 received Melizide, and 75 received metformin. The most common clinical adverse events in this clinical trial are listed in Table 5.

    Table 5: Clinical Adverse Events > 5% in any Treatment Group, by Primary Term, in Second- Line Therapy Study

    Common Side Effects of Melizide

    Call your doctor if any of the following side effects become severe or don't go away:

    Tell your doctor if you have any of the following side effects, and get emergency help if they become severe:

    • Dizziness
    • Jittery feelings
    • Red or itchy skin
    • Rash, hives, or blisters
    • Uncontrollable shaking

    Serious Side Effects of Melizide

    Call your doctor right away if you experience any of the following serious side effects:

    • Dark urine
    • Light-colored stools
    • Yellowing of the eyes or skin
    • Mental or mood changes
    • Fever
    • Sore throat

    If you have any of the following and can't reach your doctor, you may need emergency medical help:

    • Pain in the upper right area of the stomach
    • Unusual bleeding or bruising
    • Unusual or sudden weight gain
    • Extreme mental or mood changes
    • Seizures
    • Swelling of the eyes, face, lips, tongue, or throat

    Pregnancy and Melizide

    Melizide is an FDA Pregnancy Category C drug, which means harm to an unborn baby is possible.

    Similar drugs have caused severe low blood sugar in newborn babies whose mothers used the medicine near the time of delivery.

    Tell your physician if you are or plan to become pregnant.

    It's not known whether Melizide passes into breast milk or could harm a breastfeeding baby. Tell your doctor if you are breastfeeding.

    Generic Name: Melizide (GLIP i zide)Brand Names: Glucotrol

    Medically reviewed by Sanjai Sinha, MD Last updated on Jan 11, 2019.

    Before and During Use

    What do I need to tell my doctor BEFORE I take this drug?

    If you have an allergy to Melizide or any other part of this drug.If you have a sulfa allergy.If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.If you have any of these health problems: Acidic blood problem or type 1 diabetes.If you have G6PD deficiency.This is not a list of all drugs or health problems that interact with this drug.Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

    What are some things I need to know or do while I take this drug?

    Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.Check your blood sugar as you have been told by your doctor.Have blood work checked as you have been told by the doctor. Talk with the doctor.This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.Follow the diet and workout plan that your doctor told you about.Do not drive if your blood sugar has been low. There is a greater chance of you having a crash.Avoid drinking alcohol while taking this drug.If you also take colesevelam, take it at least 4 hours after you take this drug.It may be harder to control your blood sugar during times of stress like when you have a fever, an infection, an injury, or surgery. A change in level of physical activity or exercise and a change in diet may also affect your blood sugar. Talk with your doctor.This drug may raise the chance of death from heart disease. Talk with your doctor.Low blood sugar may happen with this drug. Very low blood sugar can lead to seizures, passing out, long lasting brain damage, and sometimes death. Talk with the doctor.If you are 65 or older, use this drug with care. You could have more side effects.Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.Low blood sugar has happened in infants born to women who took a drug like this one until the birth date. If this drug is used during pregnancy, you will need to stop taking it some time before your due date. Talk with your doctor.Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

    What other information should I know?

    Keep all appointments with your doctor and the laboratory. Your blood sugar and urine sugar levels should be checked regularly to determine your response to Melizide. Your doctor may order other lab tests, including glycosylated hemoglobin (HbA1c), to check your response to Melizide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

    If you are taking the extended-release tablets you may notice something that looks like a tablet in your bowel movement. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.

    You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

    Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

    It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    What Other Drugs Interact with Melizide ?

    If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

    Severe Interactions of Melizide include:

    Serious Interactions of Melizide include:

    • aminolevulinic acid
    • ethanol
    • lumacaftor/ivacaftor
    • methyl aminolevulinate

    Melizide has moderate interactions with at least 156 different drugs.

    Melizide has mild interactions with at least 91 different drugs.

    This information does not contain all possible interactions or adverse effects. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine.

    Q: I wake up in the middle of the night feeling queasy. I'm on Melizide, Dyazide, and Lipitor. I've been on Lipitor for years, so that is not the problem; however the other two meds are new. Could either or both of these meds be causing my problem?

    A: Sometimes stomach upset can be a side effect of medication, but this usually goes away during the first two weeks of treatment. If it continues to be a problem, you should consult with your physician.


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