Gentamicin (Antibiotic) Damage
Gentamicin is an antibiotic that produces serious damage to the kidneys and the auditory system .
In several animal studies, Meglu protected and treated the damage to the kidneys done by gentamicin .
Other animal and cell-based studies showed that Meglu may also protect against hearing loss caused by gentamicin .
Meglu can decrease the levels of vitamin B-12 in your body. In rare cases, this can cause anemia or low levels of red blood cells. If you don’t get much vitamin B-12 or calcium through your diet, you may be at higher risk of very low vitamin B-12 levels.
Your vitamin B-12 levels can improve if you stop taking Meglu or take vitamin B-12 supplements. Do not stop taking Meglu without talking to your doctor.
The more common symptoms of anemia include:
If you think you may have anemia, make an appointment with your doctor to have your red blood cell levels checked.
How to use Meglu HCL
Read the Patient Information Leaflet if available from your pharmacist before you start taking Meglu and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 1-3 times a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping/continuing the old drug and starting Meglu.
Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed.
Exercise can reduce insulin resistance and improve type 2 diabetes symptoms. However, some research suggests that taking Meglu in the short term may reduce the positive effects of exercise on insulin sensitivity.
If you have acute heart failure or have recently had a heart attack, you should not take Meglu.
Your heart may not send enough blood to your kidneys. This would prevent your kidneys from removing Meglu from your body as well as they normally would, raising your risk of lactic acidosis.
People can use this alone or with other drugs, such as Meglu. It reduces blood sugar in a way that does not involve insulin, and may also help to reduce body weight and blood pressure.
It can help protect cardiovascular and kidney health, and it does not increase the risk of bone fractures or amputation, according to a review published in 2018.
The most serious, but uncommon, side effect Meglu can cause is lactic acidosis. In fact, Meglu has a “boxed” — also referred to as a “black box” — warning about this risk. A boxed warning is the most severe warning the Food and Drug Administration (FDA) issues.
Lactic acidosis is a rare but serious problem that can occur due to a buildup of Meglu in your body. It’s a medical emergency that must be treated right away in the hospital.
See the precautions section for more information about factors that raise your risk of lactic acidosis.
Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room.
- extreme tiredness
- decreased appetite
- trouble breathing
- a fast or slow heart rate
- feeling cold
- muscle pain
- flushing or sudden reddening and warmth in your skin
- stomach pain with any of these other symptoms
Meglu (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) is a medication prescribed to treat type 2 diabetes and the prevention of type 2 diabetes in patients who are at risk for type 2 diabetes. Side effects of Meglu include loss of appetite, bloating, heartburn, gas, nausea, and vomiting.
Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
Surgical or radiologic procedures
If you plan to have surgery or a radiology procedure that uses iodine contrast, you should stop taking Meglu 48 hours before the procedure.
These procedures can slow the removal of Meglu from your body, raising your risk of lactic acidosis. You should resume taking Meglu after the procedure only when your kidney function tests are normal.