Losatrix tablets

Losatrix

  • Active Ingredient: Losartan
  • 50 mg, 25 mg
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What is Losatrix?

The active ingredient of Losatrix brand is losartan. Losartan is an angiotensin II receptor antagonist. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. C22H22ClKN6O M.W. 461.01 Losartan potassium, USP is a white to off-white free-flowing crystalline powder. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of Losartan. Losartan potassium tablets USP are available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of Losartan potassium, USP and the following inactive ingredients: D&C Yellow #10 aluminum lake, FD&C Blue #2/indigo carmine aluminum lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, pregelatinized starch, talc, and titanium dioxide. Additionally, 50 mg and 100 mg tablets contain FD&C Yellow #6/sunset yellow FCF aluminum lake. Losartan potassium tablets USP, 25 mg, 50 mg and 100 mg contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively.

Used for

Losatrix is used to treat diseases such as: Alport Syndrome, Diabetic Kidney Disease, High Blood Pressure.

Side Effect

Possible side effects of Losatrix include: Black, tarry stools; cough; large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs; heartburn; redness or other discoloration of the skin; frequent urge to urinate.

How to Buy Losatrix tablets online?

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What Is Losatrix (Cozaar)?

Losatrix, sold under the brand name Cozaar, is used to treat high blood pressure (hypertension).

It's also used to lower the risk of stroke in some patients with heart disease.

Losatrix is an angiotensin receptor blocker (ARB) that blocks a substance that causes blood vessels to tighten.

By relaxing blood vessels, Losatrix helps a person maintain a lower blood pressure, increasing the supply of oxygen and blood to the heart.

Losatrix is also used to slow long-term kidney damage for people with type 2 diabetes, and it is sometimes used to treat congestive heart failure.

Losatrix was the first angiotensin receptor blocker to be sold following its approval by the Food and Drug Administration (FDA) in 1995.

It's made by Merck & Co. under the trade name Cozaar, and is also available in generic form.

Additionally, Losatrix is sold as Hyzaar (hydrochlorothiazide/Losatrix), a combination drug with a low-dose diuretic to add to its antihypertensive effect.

What is Losatrix, and how does it work (mechanism of action)?

Losatrix is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). Other ARBs include irbesartan (Avapro), valsartan (Diovan), and candesartan (Atacand). Angiotensin formed in the blood by the action of angiotensin converting enzyme (ACE) is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells of blood vessels. Angiotensin's attachment to the receptors causes the muscle cells to contract and the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Losatrix (more specifically, the chemical formed when the liver converts the inactive Losatrix into its active form) blocks the angiotensin receptor. By blocking the action of angiotensin, Losatrix relaxes muscle cells and dilates blood vessels thereby reducing blood pressure.

The FDA approved lorsartan in April 1995.

Losatrix dosing information

Usual Adult Dose of Losatrix for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day. Maintenance dose: 25 to 100 mg orally in 1 to 2 divided doses.

Before taking Losatrix

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking Losatrix it is important that your doctor knows:

  • If you are pregnant or breastfeeding.
  • If you know you have a blockage of the artery which supplies blood to your k >

Michael Stewart, Reviewed by Sid Dajani | Last edited 25 Feb 2019 | Certified by The Information Standard

Take Losatrix once each day. You can take your doses either before or after a meal.

Any side-effects are usually mild, and can include feeling dizzy or light-headed.

Some painkillers can interfere with Losatrix and increase the risk of side-effects, so ask a pharmacist for advice before you buy any medicines 'over the counter'.

Clinical author's note: Michael Stewart 15/11/2018: Following an MHRA update, new advice has been added to this leaflet for people also taking the blood pressure medicine hydrochlorothiazide. Hydrochlorothiazide is only available in the UK in combination with other blood pressure medicines such as Losatrix. It may be available on its own in other countries. For more information see 'Getting the most from your treatment' below or view the MHRA Alert.

Important information

Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Losatrix can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.

You should not use this medication if you are allergic to Losatrix.

If you have diabetes, do not use Losatrix together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

In extremely rare cases, Losatrix can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Will my dose go up or down?

After a few weeks your doctor will check your blood pressure and ask you if you're getting any side effects. You may also have blood tests to check how well your kidneys are working and the amount of potassium in your blood. Your doctor will then decide whether to change your dose of Losatrix.

If Losatrix doesn't bring your blood pressure down, your doctor may want to increase the dose. If your blood pressure gets too low or you get side effects, your doctor may want to lower your dose.

Before taking Losatrix,

  • tell your doctor and pharmacist if you are allergic to Losatrix, any other medications, or any of the ingredients in Losatrix tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor if you have diabetes (high blood sugar) and you are taking aliskiren (Tekturna, in Amturnide, Tekamlo, Tekturna HCT). Your doctor will probably tell you not to take Losatrix if you have diabetes and you are also taking aliskiren.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec), fosinopril, lisinopril (in Prinzide, in Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), and selective COX-2 inhibitors such as celecoxib (Celebrex); diuretics ('water pills') including potassium-sparing diuretics such as amiloride (Midamor), spironolactone (Aldactone, in Aldactazide), and triamterene (Dyrenium, in Dyazide, in Maxzide); fluconazole (Diflucan); lithium ( Lithobid); phenobarbital; potassium supplements; and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have or have ever had heart failure or kidney or liver disease.
  • tell your doctor if you are breastfeeding.
  • you should know that Losatrix may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking Losatrix. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
  • you should know that diarrhea, vomiting, not drinking enough fluids, and sweating a lot can cause a drop in blood pressure, which may cause lightheadedness and fainting. Tell your doctor if you have any of these problems or develop them during your treatment.

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