Blood pressure and heart drugs (angiotensin-converting enzyme inhibitors)
These drugs can increase the effect of Limeral and cause low blood sugar. Examples of these drugs include:
- benazepril (Lotensin)
- captopril (Capoten)
- enalapril (Vasotec)
- fosinopril (Monopril)
- lisinopril (Prinivil)
- moexipril (Univasc)
- perindopril (Aceon)
- quinapril (Accupril)
- ramipril (Altace)
- trandolapril (Mavik)
These drugs can decrease the effect of Limeral and cause high blood sugar. Examples of these drugs include:
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
Why is this medication prescribed?
Limeral is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Limeral lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Limeral is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
What is Limeral (Amaryl)?
Limeral is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.
Limeral may also be used for purposes not listed in this medication guide.
How should I take Limeral (Amaryl)?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Limeral is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Limeral with a full glass of water.
Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.
You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).
Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Limeral is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.
Store at room temperature away from moisture and heat.
Dosage for type 2 diabetes
Adult dosage (ages 18 to 64 years)
- The recommended starting dose is 1 mg or 2 mg taken once per day with breakfast or the first main meal of the day.
- After reaching a dose of 2 mg per day, your doctor may increase your dose by 1 mg or 2 mg based on your blood sugar levels. They may increase your dose every 1 to 2 weeks until your blood sugar levels are controlled.
- The maximum recommended dose is 8 mg taken once per day.
Child dosage (ages 0 to 17 years)
Limeral isn’t recommended for people under 18 years old because it may affect body weight and cause low blood sugar.
Senior dosage (ages 65 years and older)
- The starting dose is 1 mg taken once per day with breakfast or the first main meal of the day.
- Your doctor may adjust your dose based on your blood sugar levels. Since seniors may be more sensitive to Limeral and are more likely to have decreased kidney function, your doctor may increase your dose more slowly.
- The maximum recommended dose is 8 mg taken once per day.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Studies in rats at doses of up to 5000 parts per million (ppm) in complete feed (approximately 340 times the maximum recommended human dose, based on surface area) for 30 months showed no evidence of carcinogenesis. In mice, administration of Limeral for 24 months resulted in an increase in benign pancreatic adenoma formation that was dose-related and was thought to be the result of chronic pancreatic stimulation. No adenoma formation in mice was observed at a dose of 320 ppm in complete feed, or 46 to 54 mg/kg body weight/day. This is at least 28 times the maximum human recommended dose of 8 mg once daily based on surface area.
Glimepir >in vitro and in vivo mutagenicity studies (Ames test, somatic cell mutation, chromosomal aberration, unscheduled DNA synthesis, and mouse micronucleus test).
There was no effect of Limeral on male mouse fertility in animals exposed up to 2,500 mg/kg body weight (>1,500 times the maximum recommended human dose based on surface area). Limeral had no effect on the fertility of male and female rats administered up to 4,000 mg/kg body weight (approximately 4,000 times the maximum recommended human dose based on surface area).