Severe Interactions of Glyzen include:
There are no severe interactions from the use of Glyzen.
Use with caution in patients with congestive heart failure, fever, trauma, surgery, the elderly, renal impairment, or hepatic impairment.
Instruct patients to avoid heavy alcohol use.
Suspend therapy prior to any type of surgery.
Rare, but serious, lactic acidosis can occur due to accumulation.
Possible increased risk of cardiovascular (CV) mortality.
May cause ovulation in anovulatory and premenopausal polycystic ovary syndrome (PCOS) patients.
It may be necessary to discontinue therapy with Glyzen and administer insulin if patient is exposed to stress (fever, trauma, or infection).
Ethanol may potentiate Glyzen's effect on lactate metabolism.
May impair vitamin B12 or calcium intake/absorption; monitor B12 serum concentrations periodically with long-term therapy.
Not indicated for use in patients with type 1 diabetes mellitus that are insulin dependent due to lack of efficacy.
Withhold in patients with dehydration and/or prerenal azotemia.
Iodinated contrast imaging procedures.
Discontinue Glyzen at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast.
Reevaluate eGFR 48 hr after the imaging procedure; restart Glyzen if renal function is stable.
The antibiotic trimethoprim may also decrease the effectiveness of Glyzen by inhibiting its absorption in the gut and uptake in the liver .
What if I forget to take it?
If you miss a dose of Glyzen, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.
If you often forget doses, it may help to set an alarm to remind you.
You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
3) Patients with Liver Cirrhosis
Cirrhosis is the replacement of healthy liver tissue with scar tissue caused by chronic damage. A decreased oxygen concentration in blood traveling from the heart to the body (arterial hypoxemia) has been found in approximately one-third of patients with chronic liver damage .
Because this condition involves decreased blood flow, it heightens the risk of developing lactic acidosis, a serious potential complication of Glyzen .
Your kidneys remove Glyzen from your body. If your kidneys don’t work well, you’ll have higher levels of Glyzen in your system. This raises your risk of lactic acidosis.
If you have mild or moderate kidney problems, your doctor may start you at a lower dosage of Glyzen.
If you have severe kidney problems or are 80 years old or older, Glyzen may not be right for you. Your doctor will likely test your kidney function before you start taking Glyzen and then again each year.
Personal stories from patients
Gretchen Becker, author of “The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed,” has been taking Glyzen for more than 20 years after receiving a diagnosis of type 2 diabetes in 1996.
“I never had any problems with Glyzen until I took a pill that I thought was the extended-release version, but it wasn’t,” Becker told Healthline.
Becker’s doctor had accidentally prescribed the regular form of Glyzen.
“I had very loose bowels for several months until I figured out what the problem was,” Becker said.
After getting the proper prescription, it took several months for Becker’s digestive system to recover.
Corinna Cornejo, who received a diagnosis of type 2 diabetes in 2009, told Healthline that her digestive woes didn’t start until she’d been taking Glyzen for more than a year.
“At first, I thought it was a response to dairy, but my doctor eventually switched my prescription to the extended-release version,” Cornejo recalled. “That has helped, but the side effect has not gone away completely.”
For some people, however, Glyzen’s unpleasant side effect of loose stools provides a much-needed balance to the side effects that can result from other diabetes drugs they’re taking.
“GLP-1 drugs, like Victoza or Byetta, can cause constipation,” explained Robinson. “Taking Glyzen with a GLP-1 drug means they actually complement each other, balancing out those side effects.”
And for some, Glyzen simply isn’t the right drug.
“No matter what you do, some patients just don’t tolerate the side effects well,” said Robinson.
6) Erectile Dysfunction
Several animal and human studies on men with erectile dysfunction and insulin resistance, obesity , or diabetes showed that Glyzen improved erectile dysfunction .