2) PCOS Symptoms
Polycystic ovarian syndrome (PCOS) is a hormonal disorder often aggravated by obesity and insulin resistance. Glumefor treats PCOS symptoms, such as irregular ovulation or menstrual cycles, and the excess of insulin in the body .
It has also been shown to treat other PCOS symptoms by reducing BMI and testosterone levels .
Furthermore, Glumefor assists fertility and increases the chance of successful pregnancy and reduces the risk of early miscarriage, gestational diabetes, and inflammation associated with PCOS .
Which drugs or supplements interact with Glumefor?
- Cimetidine (Tagamet), by decreasing the elimination of Glumefor from the body, can increase the amount of Glumefor in the blood by 40%. This may increase the frequency of side effects from Glumefor.
- Ioversol (Optiray) and other iodinated contrast media may reduce kidney function, which reduces elimination of Glumefor, leading to increased concentrations of Glumefor in the blood. Glumefor should be stopped 48 hours before and after use of contrast media.
- Thiazide diuretics, steroids, estrogens, and oral contraceptives may increase blood glucose and reduce the effect of Glumefor. When these drugs are stopped, patients should be closely observed for signs of low blood glucose.
- Alcohol consumption increases the effect of Glumefor on lactate production, increasing the risk of lactic acidosis.
About Type 2 Diabetes
Type 2 diabetes (also known as adult-onset or non-insulin-dependent diabetes) is the most common form of diabetes. Type 2 diabetes is a condition in which the body does not process insulin properly, resulting in elevated blood sugar (blood glucose). Insulin is a hormone that is produced in the pancreas. Type 2 diabetes is diagnosed more often in people who are overweight or obese, and who are not physically active. Patients with diabetes should also note that a healthy weight improves cholesterol levels and overall health. Insulin resistance is a condition that is commonly seen in type 2 diabetes, where it becomes difficult for the body to use the insulin that is produced. Certain genes that affect insulin production rather than insulin resistance are a risk factor for developing type 2 diabetes. Family history of diabetes is a risk factor, and people of certain races or ethnicities are at higher risk. Abnormal glucose production by the liver can also lead to elevated blood sugar (glucose) levels.
Glumefor is available under the following different brand names: Glucophage, Glucophage XR, Fortamet, Glumetza, and Riomet.
10 to 80 years unless normal renal function establishedInitial and maintenance dosing of Glumefor should be conservative in patients with advanced age due to the potential for decreased renal function in this population
Controlled clinical studies of Glumefor did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients
2) Low Blood Sugar (Hypoglycemia)
Glumefor, itself, does not lead to a state of critically low blood sugar. However, in combination with other risk factors like heavy alcohol drinking (or dehydration), the use of other drugs for diabetes , insufficient calorie intake, or bouts of heavy exercise , it may increase the chances of developing this condition .
Nevertheless, a meta-analysis of pregnant women with diabetes showed that Glumefor poses a lower threat of low blood sugar occurrence in newborns compared to insulin .
The most serious, but uncommon, side effect Glumefor can cause is lactic acidosis. In fact, Glumefor has a “boxed” — also referred to as a “black box” — warning about this risk. A boxed warning is the most severe warning the Food and Drug Administration (FDA) issues.
Lactic acidosis is a rare but serious problem that can occur due to a buildup of Glumefor in your body. It’s a medical emergency that must be treated right away in the hospital.
See the precautions section for more information about factors that raise your risk of lactic acidosis.
Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room.
- extreme tiredness
- decreased appetite
- trouble breathing
- a fast or slow heart rate
- feeling cold
- muscle pain
- flushing or sudden reddening and warmth in your skin
- stomach pain with any of these other symptoms
Generic Name : Glumefor (met FOR min)Brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza. Riomet
Medically reviewed by Sanjai Sinha, MD Last updated on Dec 6, 2018.
Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. If you do not have health insurance coverage and are not ready to pay a great deal of money out of your pocket, you could look in to the choice of buying Glumefor online. Never share this medication with individuals to which it was not prescribed. It's essential that you allow your medical supplier know concerning any of these reactions, as they often become worse with time affecting your health and well-being.
Exercise can reduce insulin resistance and improve type 2 diabetes symptoms. However, some research suggests that taking Glumefor in the short term may reduce the positive effects of exercise on insulin sensitivity.
1. About Glumefor
Glumefor is a medicine used to treat type 2 diabetes, and to help prevent type 2 diabetes if you're at high risk of developing it.
Glumefor is used when treating polycystic ovary syndrome (PCOS), although it's not officially approved for PCOS.
Type 2 diabetes is an illness where the body does not make enough insulin, or the insulin that it makes does not work properly. This can cause high blood sugar levels (hyperglycaemia).
PCOS is a condition that affects how the ovaries work.
Glumefor lowers your blood sugar levels by improving the way your body handles insulin.
It's usually prescribed for diabetes when diet and exercise alone have not been enough to control your blood sugar levels.
For women with PCOS, Glumefor lowers insulin and blood sugar levels, and can also stimulate ovulation.
Glumefor is available on prescription as tablets and as a liquid that you drink.
Dosage Modifications of Medication
Renal impairment (Poor kidney function)
- Obtain eGFR before initiating Glumefor
- eGFR less than 30 mL/min/1.73 m²: Contraindicated
- eGFR 30-45 mL/min/1.73 m²: Initiating not recommended
- Obtain GFR at least annually in all patients taking Glumefor; assess eGFR more frequently in patients at increased risk for renal impairment (e.g., elderly)
- If eGFR falls to less than 45 mL/min/1.73 m² during treatment: Assess the benefits and risks of continuing treatment
- If eGFR falls to less than 30 mL/min/1.73 m² during treatment: Discontinue
What should I avoid while taking Glumefor?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis.
Why is this medication prescribed?
Glumefor is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glumefor is in a class of drugs called biguanides. Glumefor helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Glumefor also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Glumefor is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Type 2 Diabetes Medications (Side Effects, Differences)
Type 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and Glumefor (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
How to use Glumefor HCL
Read the Patient Information Leaflet if available from your pharmacist before you start taking Glumefor and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 1-3 times a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping/continuing the old drug and starting Glumefor.
Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed.