Glucogood tablets

Glucogood

  • Active Ingredient: Metformin
  • 850 mg, 500 mg
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What is Glucogood?

The active ingredient of Glucogood brand is metformin. Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin hydrochloride, USP is a white to off-white crystalline compound with a molecular formula of C4H11N5 • HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of Metformin is 12.4. The pH of a 1% aqueous solution of Metformin hydrochloride is 6.68. Metformin hydrochloride tablets contain 500 mg, 850 mg, or 1000 mg of Metformin hydrochloride. Each tablet contains the inactive ingredients povidone (K-30), povidone (K-90), pregelatinized starch, and magnesium stearate. In addition, the coating for the tablets contains artificial blackberry flavor, hypromellose, macrogol and titanium dioxide.

Used for

Glucogood is used to treat diseases such as: Diabetes, Type 2, Diabetes, Type 3c, Female Infertility, Insulin Resistance Syndrome, Polycystic Ovary Syndrome.

Side Effect

Possible side effects of Glucogood include: difficulty with concentrating; nausea; flu-like symptoms; tightness in the chest; cool, pale skin; shortness of breath; sneezing; Abnormal stools.

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Cautions

Use with caution in patients with congestive heart failure, fever, trauma, surgery, the elderly, renal impairment, or hepatic impairment.

Instruct patients to avoid heavy alcohol use.

Suspend therapy prior to any type of surgery.

Rare, but serious, lactic acidosis can occur due to accumulation.

Possible increased risk of cardiovascular (CV) mortality.

May cause ovulation in anovulatory and premenopausal polycystic ovary syndrome (PCOS) patients.

It may be necessary to discontinue therapy with Glucogood and administer insulin if patient is exposed to stress (fever, trauma, or infection).

Ethanol may potentiate Glucogood's effect on lactate metabolism.

May impair vitamin B12 or calcium intake/absorption; monitor B12 serum concentrations periodically with long-term therapy.

Not indicated for use in patients with type 1 diabetes mellitus that are insulin dependent due to lack of efficacy.

Withhold in patients with dehydration and/or prerenal azotemia.

Iodinated contrast imaging procedures.

Discontinue Glucogood at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast.

Reevaluate eGFR 48 hr after the imaging procedure; restart Glucogood if renal function is stable.

You're not really in the mood to eat.

“One of the ways that people hypothesize Glucogood helps with weight loss is that, in some patients, it can help curb your appetite a little bit,” says Rodriguez. When your body’s insulin doesn’t respond normally, it can lead to cravings. Glucogood can help stabilize insulin levels, thereby helping improve or curbing that sensation of extra hunger, she explains.

What Is Glucogood and How Does It Work?

Glucogood is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target cell insulin sensitivity. This medication is a treatment indicated as an adjunct to diet, exercise, and lifestyle changes such as weight loss to improve glycemic (blood sugar) control in adults with type 2 diabetes. Many patients with type 2 diabetes will eventually need to take insulin by injection. Glucogood does not cause weight gain.

5) Weight Loss

In a clinical trial on 46 middle-aged women with high insulin relative to blood sugar levels and weight gain, Glucogood along with a special diet helped sustain weight loss .

Glucogood also decreased waist circumference and body mass index (BMI) in 19 HIV-infected patients with an abnormal distribution of body fat (lipodystrophy) .

However, Glucogood had no effect on weight loss after giving birth in another trial on 114 women with gestational diabetes .

2) Use During Pregnancy and Breastfeeding

A review of several studies showed that Glucogood does not have any acute negative effects on pregnancy outcomes. However, there is not enough evidence regarding its prolonged use during pregnancy. Pregnant women should always consult their doctors about the potential risks of using Glucogood .

Moreover, several human studies have shown that Glucogood may decrease the relative risks of pregnancy complications, miscarriage, premature birth, and early pregnancy loss in women with polycystic ovarian syndrome .

Because regulating their blood sugar and insulin levels is crucial to pregnant women, the benefits of taking Glucogood generally outweigh the risks.

A study of seven women taking Glucogood immediately after giving birth showed that, although traces of the drug were found in the milk, they were too low to have any effects on the blood sugar levels of the babies .

What is the dosage for Glucogood?

  • For treating type 2 diabetes in adults, Glucogood (immediate release) usually is begun at a dose of 500 mg twice a day or 850 mg once daily. The dose is gradually increased by 500 mg weekly or 850 mg every two weeks as tolerated and based on the response of the levels of glucose in the blood. The maximum daily dose is 2550 mg given in three divided doses.
  • If extended tablets are used, the starting dose is 500 mg or 1000 mg daily with the evening meal. The dose can be increased by 500 mg weekly up to a maximum dose of 2000 mg except for Fortamet (2500 mg of Fortamet, once daily or in two divided doses). Glumetza tablets (500 -1000mg formulations are given once daily (either 1000 to 2000mg). Fortamet and Glumetza are modified release formulations of Glucogood. Glucogood should be taken with meals.
  • For pediatric patients 10-16 years of age, the starting dose is 500 mg twice a day. The dose can be increased by 500 mg weekly up to a maximum dose of 2000 mg in divided doses.
  • Children older than 17 years of age may receive 500 mg of extended release tablets daily up to a maximum dose of 2000 mg daily. Extended release tablets are not approved for children younger than 17 years of age.
  • Glucogood-containing drugs may be safely used in patients with mild to moderate renal impairment. Renal function should be assessed before starting treatment and at least yearly.
  • Glucogood should not be used by patients with an estimated glomerular filtration rate (eGFR) below 30 mL/minute/1.73 m2 and starting Glucogood in patients with an eGFR between 30-45 mL/minute/1.73 m2 is not recommended.
  • Glucogood should be stopped at the time of or before administering iodinated contrast in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Kidney function should be evaluated 48 hours after receiving contrast and Glucogood may be restarted if kidney function is stable.

Glucogood is a medication that helps people manage type 2 diabetes and occasionally prediabetes. Typically, doctors advise that drinking alcohol while taking Glucogood does not support diabetes management and is not safe.

The side effects of Glucogood can be life-threatening when a person takes it while drinking excessive amounts of alcohol.

Glucogood and alcohol both put stress on the liver, intensifying the harmful effects of both and increasing the risk of liver complications.

In this article, we look at the possible interactions between Glucogood and alcohol, as well as the complications that might occur after mixing them.

Important Information

You should not use Glucogood if you have severe k >metabolic acidosis , or diabetic ketoacidosis (call your doctor for treatment).

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glucogood.

Though extremely rare, you may develop lactic acidosis , a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Will my dose go up or down?

Your doctor will check your blood sugar levels regularly and may change your dose of Glucogood if necessary.

When you first start taking Glucogood standard-release tablets, you'll be advised to increase the dose slowly. This reduces the chances of getting side effects.

  • 1 500mg tablet with or after breakfast for at least 1 week, then
  • 1 500mg tablet with or after breakfast and your evening meal for at least 1 week, then
  • 1 500mg tablet with or after breakfast, lunch and your evening meal

If you find you cannot tolerate the side effects of standard-release Glucogood, your doctor may suggest switching to slow-release tablets.

Summary

Glucogood (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet) is a medication prescribed to treat type 2 diabetes and the prevention of type 2 diabetes in patients who are at risk for type 2 diabetes. Side effects of Glucogood include loss of appetite, bloating, heartburn, gas, nausea, and vomiting.

Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.

Glucogood is generally a safe and effective treatment for type 2 diabetes. However, it can cause side effects, and some people may want to look at other options.

Type 2 diabetes occurs when the body's cells stop responding to insulin appropriately. As a result, levels of glucose, or sugar, in the blood rise too high.

Certain lifestyle factors can increase the risk of type 2 diabetes, including:

  • being overweight or obese
  • engaging in low levels of physical activity
  • eating a poor diet

Glucogood is an oral medication that helps manage the effects of type 2 diabetes. In people with prediabetes, the drug can also help prevent or delay the onset of the condition. Doctors prescribe Glucogood to nearly 120 million people worldwide.

In this article, we look at the side effects of Glucogood and why a person with type 2 diabetes might want to stop taking it. We also look at the risk of not taking Glucogood and some alternative options.

You've got some serious tummy troubles.

Glucogood is most notorious for causing a wide array of stomach issues. “It varies from person to person, but up to 40 to 50 percent of people who use classic Glucogood can develop diarrhea, nausea, vomiting, and/or gassiness,” says Rodriguez.

Why Glucogood leads to GI distress is unclear, but “because this medication is metabolized by the liver, people who are heavy alcohol drinkers or who already have problems with acid reflux or IBS may be more predisposed to this side effect,” she adds.

Most of the time, your body adjusts after just a couple of days and the symptoms improve; if not, your doctor can adjust the dosage or even take you off the drug.


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