Glimedoc tablets


  • Active Ingredient: Glimepiride
  • 4 mg, 2 mg, 1 mg
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What is Glimedoc?

The active ingredient of Glimedoc brand is glimepiride. Glimepiride is an oral diabetes medicine that helps control blood sugar levels. Glimepiride tablets contain the active ingredient Glimepiride and the following inactive ingredients:lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate (potato). In addition, the 2 mgand 4 mg tablets contain D&C Yellow No. 10 Aluminum Lake and the 4 mg also contains D&C Red No. 27 Aluminum Lake.

Used for

Glimedoc is used to treat diseases such as: Diabetes, Type 2.

Side Effect

Possible side effects of Glimedoc include: fast heartbeat; blurred vision; difficulty with breathing; skin rash; Abdominal or stomach pain.

How to Buy Glimedoc tablets online?

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Concomitant Administration Of Colesevelam

Colesevelam can reduce the maximum plasma concentration and total exposure of Glimedoc when the two are coadministered. However, absorption is not reduced when Glimedoc is administered 4 hours prior to colesevelam. Therefore, AMARYL should be administered at least 4 hours prior to colesevelam.

Mechanism of Action

Glimedoc primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta cells. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.


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Drug that treats eye infections

Chloramphenicol can increase the effect of Glimedoc and cause low blood sugar.

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Where can I get more information?

Your pharmacist can provide more information about Glimedoc.

What should I discuss with my healthcare provider before taking Glimedoc (Amaryl)?

You should not use Glimedoc if you are allergic to it, or if you have:

  • an allergy to sulfa drugs; or
  • diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

  • heart disease;
  • liver or kidney disease; or
  • an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Glimedoc may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

Medications similar to Glimedoc have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take Glimedoc during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking Glimedoc, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Glimedoc is not approved for use by anyone younger than 18 years old.

Why is this medication prescribed?

Glimedoc is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Glimedoc lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Glimedoc is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

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Pediatric Use

The pharmacokinetics, efficacy and safety of Glimedoc have been evaluated in pediatric patients with type 2 diabetes as described below. Glimedoc tablets are not recommended in pediatric patients because of its adverse effects on body weight and hypoglycemia.

The pharmacokinetics of a 1 mg single dose of Glimepir >(0-last) (339±203 ng•hr/mL), C max (102±48 ng/mL) and t 1/2 (3.1±1.7 hours) for Glimepir >(0-last) 315±96 ng•hr/mL, C max 103±34 ng/mL and t 1/2 5.3±4.1 hours).

The safety and efficacy of Glimepir >

After 24 weeks, the overall mean treatment difference in HbA 1c between Glimedoc and metformin was 0.2%, favoring metformin (95% confidence interval -0.3% to +0.6%).

Based on these results, the trial d >1c with Glimedoc compared to metformin.

Pediatric Use

The pharmacokinetics, efficacy and safety of AMARYL have been evaluated in pediatric patients with type 2 diabetes as described below. AMARYL is not recommended in pediatric patients because of its adverse effects on body weight and hypoglycemia.

The pharmacokinetics of a 1 mg single dose of AMARYL was evaluated in 30 patients with type 2 diabetes (male = 7; female = 23) between ages 10 and 17 years. The mean (± SD) AUC (339±203 ng·hr/mL), Cmax (102±48 ng/mL) and t½ (3.1±1.7 hours) for Glimedoc were comparable to historical data from adults (AUC(0-last) 315±96 ng·hr/mL, Cmax 103±34 ng/mL and t½ 5.3±4.1 hours).

The safety and efficacy of AMARYL in pediatric patients was evaluated in a single-blind, 24-week trial that randomized 272 patients (8-17 years of age) with type 2 diabetes to AMARYL (n=135) or metformin (n=137). Both treatment-naive patients (those treated with only diet and exercise for at least 2 weeks prior to randomization) and previously treated patients (those previously treated or currently treated with other oral antidiabetic medications for at least 3 months) were eligible to participate. Patients who were receiving oral antidiabetic agents at the time of study entry discontinued these medications before randomization without a washout period. AMARYL was initiated at 1 mg, and then titrated up to 2, 4 or 8 mg (mean last dose 4 mg) through Week 12, targeting a self-monitored fasting fingerstick blood glucose

The profile of adverse reactions in pediatric patients treated with AMARYL was similar to that observed in adults .

Hypoglycemic events documented by blood glucose values 65 years of age. No overall differences in safety or effectiveness were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

There were no significant differences in glimepir > 65 years (n=42) .

Glimedoc is substantially excreted by the kidney. Elderly patients are more likely to have renal impairment. In addition, hypoglycemia may be difficult to recognize in the elderly . Use caution when initiating AMARYL and increasing the dose of AMARYL in this patient population.

What other drugs will affect Glimedoc (Amaryl)?

Glimedoc may not work as well when you use other medicines at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

If you also take colesevelam, take your Glimedoc dose at least 4 hours before you take colesevelam.

Other drugs may affect Glimedoc, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

How should I take Glimedoc?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Glimedoc is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Glimedoc with a full glass of water.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Glimedoc is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

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