6. How to cope with s >
What to do about:
- feeling sick - take Glifortex with food to reduce the chances of feeling sick. It may also help to slowly increase your dose over several weeks. Ask a pharmacist or your doctor for advice.
- being sick (vomiting) or diarrhoea - drink lots of fluids, such as water or squash, to avoid dehydration. Take small, frequent sips if you're being sick. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Do not take any other medicines to treat diarrhoea or vomiting without speaking to a pharmacist or doctor.
- stomach pain - try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you're in a lot of pain, speak to your pharmacist or doctor.
- loss of appetite - eat when you'd usually expect to be hungry. If it helps, eat smaller meals more often than usual.
- a metallic taste in the mouth - if you find that Glifortex is giving you a metallic taste in the mouth, try chewing sugar-free gum
Black Box Warnings
Lactic acidosis is a rare, but potentially severe, consequence of therapy with Glifortex; it is characterized by elevated blood lactate levels (>5 mmol/L), decreased blood pH, electrolyte disturbances with an increased anion gap, and an increased lactate/pyruvate ratio; when Glifortex is implicated as the cause of lactic acidosis, Glifortex plasma concentrations >5 mcg/mL are generally found
Risk factors for Glifortex-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (e.g., acute congestive heart failure), excessive alcohol intake, and hepatic impairment; if Glifortex-associated lactic acidosis is suspected, immediately discontinue
Patients with CHF requiring pharmacologic management, in particular those with unstable or acute CHF who are at risk for hypoperfusion and hypoxemia, are at an increased risk for lactic acidosis; the risk for lactic acidosis increases with the degree of renal dysfunction and the patient’s age
Do not start in patients aged 80 years or older unless CrCl demonstrates that renal function is not reduced, because these patients are more susceptible to developing lactic acidosis; Glifortex should be promptly withheld in the presence of any condition associated with hypoxemia, dehydration, or sepsis
Should generally be avoided in patients with clinical or laboratory evidence of hepatic disease; patients should be cautioned against excessive alcohol intake, either acute or chronic, during Glifortex therapy because alcohol potentiates the effects of Glifortex on lactate metabolism
Discontinue Glifortex at the time of or before an iodinated contrast imaging procedure in patients with an eGFR between 30-60 mL/minute/1.73 m²; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinate contrast
The onset of lactic acidosis often is subtle and accompanied by nonspecific symptoms (eg, malaise, myalgias, respiratory distress, increasing somnolence, nonspecific abdominal distress); with marked acidosis, hypothermia, hypotension, and resistant bradyarrhythmias may occur; patients should be instructed regarding recognition of these symptoms and told to notify their physician immediately if the symptoms occur; Glifortex should be withdrawn until the situation is clarified; serum electrolytes, ketones, blood glucose, and, if indicated, blood pH, lactate levels, and even blood Glifortex levels may be useful
Once a patient is stabilized on any dose level of Glifortex, GI symptoms, which are common during initiation of therapy, are unlikely to be drug related; later occurrences of GI symptoms could be due to lactic acidosis or other serious disease
Lactic acidosis should be suspected in any diabetic patient with metabolic acidosis who is lacking evidence of ketoacidosis (ketonuria and ketonemia); lactic acidosis is a medical emergency that must be treated in a hospital setting; in a patient with lactic acidosis who is taking Glifortex, the drug should be discontinued immediately and general supportive care measures promptly instituted; Glifortex is highly dialyzable (clearance up to 170 mL/min under good hemodynamic conditions); prompt hemodialysis is recommended to correct the acidosis and to remove the accumulated Glifortex; such management often results in prompt reversal of symptoms and recovery
6) Erectile Dysfunction
Several animal and human studies on men with erectile dysfunction and insulin resistance, obesity , or diabetes showed that Glifortex improved erectile dysfunction .
3) Anticancer Drugs
Like the previously mentioned drugs, anticancer medications such as imatinib , nilotinib , gefitinib , and erlotinib ( tyrosine kinase inhibitors ) may decrease the effectiveness of Glifortex by inhibiting Glifortex’s absorption in the gut and uptake in the liver .
2) Use During Pregnancy and Breastfeeding
A review of several studies showed that Glifortex does not have any acute negative effects on pregnancy outcomes. However, there is not enough evidence regarding its prolonged use during pregnancy. Pregnant women should always consult their doctors about the potential risks of using Glifortex .
Moreover, several human studies have shown that Glifortex may decrease the relative risks of pregnancy complications, miscarriage, premature birth, and early pregnancy loss in women with polycystic ovarian syndrome .
Because regulating their blood sugar and insulin levels is crucial to pregnant women, the benefits of taking Glifortex generally outweigh the risks.
A study of seven women taking Glifortex immediately after giving birth showed that, although traces of the drug were found in the milk, they were too low to have any effects on the blood sugar levels of the babies .
Which drugs or supplements interact with Glifortex?
- Cimetidine (Tagamet), by decreasing the elimination of Glifortex from the body, can increase the amount of Glifortex in the blood by 40%. This may increase the frequency of side effects from Glifortex.
- Ioversol (Optiray) and other iodinated contrast media may reduce kidney function, which reduces elimination of Glifortex, leading to increased concentrations of Glifortex in the blood. Glifortex should be stopped 48 hours before and after use of contrast media.
- Thiazide diuretics, steroids, estrogens, and oral contraceptives may increase blood glucose and reduce the effect of Glifortex. When these drugs are stopped, patients should be closely observed for signs of low blood glucose.
- Alcohol consumption increases the effect of Glifortex on lactate production, increasing the risk of lactic acidosis.
What are the uses for Glifortex?
- Glifortex is used for treating type 2 diabetes in adults and children. It may be used alone or in combination with other diabetic medications.
- Glifortex also has been used to prevent the development of diabetes in people who are at risk.
- Treatment of polycystic ovaries
- Weight gain due to medications used for treating psychoses.
Glifortex is generally a safe and effective treatment for type 2 diabetes. However, it can cause side effects, and some people may want to look at other options.
Type 2 diabetes occurs when the body's cells stop responding to insulin appropriately. As a result, levels of glucose, or sugar, in the blood rise too high.
Certain lifestyle factors can increase the risk of type 2 diabetes, including:
- being overweight or obese
- engaging in low levels of physical activity
- eating a poor diet
Glifortex is an oral medication that helps manage the effects of type 2 diabetes. In people with prediabetes, the drug can also help prevent or delay the onset of the condition. Doctors prescribe Glifortex to nearly 120 million people worldwide.
In this article, we look at the side effects of Glifortex and why a person with type 2 diabetes might want to stop taking it. We also look at the risk of not taking Glifortex and some alternative options.
Elderly patients with diabetes are more likely to have decreased renal function with the use of this drug; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases.
Not for use in patients over 80 years unless normal renal function established initial and maintenance dosing of Glifortex should be conservative in patients with advanced age due to the potential for decreased renal function in this population.
Controlled clinical studies of this drug did not include sufficient numbers of elderly patients with diabetes to determine whether they respond differently from younger patients with diabetes.
Gentamicin (Antibiotic) Damage
Gentamicin is an antibiotic that produces serious damage to the kidneys and the auditory system .
In several animal studies, Glifortex protected and treated the damage to the kidneys done by gentamicin .
Other animal and cell-based studies showed that Glifortex may also protect against hearing loss caused by gentamicin .
Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. If you do not have health insurance coverage and are not ready to pay a great deal of money out of your pocket, you could look in to the choice of buying Glifortex online. Never share this medication with individuals to which it was not prescribed. It's essential that you allow your medical supplier know concerning any of these reactions, as they often become worse with time affecting your health and well-being.
How to best use Glifortex
While some degree of Glifortex’s side effects can’t be helped, Marcey Robinson, MS, RD, CSSD, CDE, BC-ADM, co-founder of Achieve Health & Performance, says there are actually several things doctors can do when prescribing Glifortex to ensure patient adherence.
However, she says, many physicians simply don’t.
The first issue, Robinson told Healthline, is that there are two types of Glifortex to choose from: regular and extended release.
Most people do better on the extended-release version because the drug’s potency is affecting the body over the course of several hours, rather than hitting you all at once.
“Sometimes, it’s just a doctor’s standard of practice and they don’t even think about it. They’ve always prescribed it one way, so that’s what they continue to do,” said Robinson.
“For some patients, the doctor might also think that having a bigger boost of the medication all at once is going to help a patient who is struggling with high blood sugars after a meal. But that’s really not how Glifortex is expected to work in the body,” she added.
Glifortex can decrease the levels of vitamin B-12 in your body. In rare cases, this can cause anemia or low levels of red blood cells. If you don’t get much vitamin B-12 or calcium through your diet, you may be at higher risk of very low vitamin B-12 levels.
Your vitamin B-12 levels can improve if you stop taking Glifortex or take vitamin B-12 supplements. Do not stop taking Glifortex without talking to your doctor.
The more common symptoms of anemia include:
If you think you may have anemia, make an appointment with your doctor to have your red blood cell levels checked.