Glifage tablets

Glifage

  • Active Ingredient: Metformin
  • 850 mg, 500 mg
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What is Glifage?

The active ingredient of Glifage brand is metformin. Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin hydrochloride, USP is a white to off-white crystalline compound with a molecular formula of C4H11N5 • HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of Metformin is 12.4. The pH of a 1% aqueous solution of Metformin hydrochloride is 6.68. Metformin hydrochloride tablets contain 500 mg, 850 mg, or 1000 mg of Metformin hydrochloride. Each tablet contains the inactive ingredients povidone (K-30), povidone (K-90), pregelatinized starch, and magnesium stearate. In addition, the coating for the tablets contains artificial blackberry flavor, hypromellose, macrogol and titanium dioxide.

Used for

Glifage is used to treat diseases such as: Diabetes, Type 2, Diabetes, Type 3c, Female Infertility, Insulin Resistance Syndrome, Polycystic Ovary Syndrome.

Side Effect

Possible side effects of Glifage include: lower back or side pain; slurred speech; fever or chills; loss of appetite; change in taste; stuffy nose.

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3) Patients with Liver Cirrhosis

Cirrhosis is the replacement of healthy liver tissue with scar tissue caused by chronic damage. A decreased oxygen concentration in blood traveling from the heart to the body (arterial hypoxemia) has been found in approximately one-third of patients with chronic liver damage .

Because this condition involves decreased blood flow, it heightens the risk of developing lactic acidosis, a serious potential complication of Glifage .

What if I take too much?

An overdose of a large number of Glifage tablets can cause serious health problems. The symptoms are severe and quick to appear.

  • stomach pain
  • diarrhoea
  • fast or shallow breathing
  • feeling cold
  • unusual sleepiness
  • tiredness or weakness

2) Low Blood Sugar (Hypoglycemia)

Glifage, itself, does not lead to a state of critically low blood sugar. However, in combination with other risk factors like heavy alcohol drinking (or dehydration), the use of other drugs for diabetes , insufficient calorie intake, or bouts of heavy exercise , it may increase the chances of developing this condition .

Nevertheless, a meta-analysis of pregnant women with diabetes showed that Glifage poses a lower threat of low blood sugar occurrence in newborns compared to insulin .

Hypoglycemia

Glifage helps regulate blood sugars, and so it can cause hypoglycemia, or low blood sugars.

This can happen if someone takes too large a dose, maintains a poor diet, or consumes too much alcohol.

Alcohol also causes dips in blood sugar levels, and so when combined with Glifage, the risk of hypoglycemia is much higher.

According to the American Diabetes Association, blood glucose levels below 70 milligrams per deciliter are too low for most people.

Symptoms in mild hypoglycemic cases, such as headaches, tiredness, and hunger, are usually too vague to be a warning sign.

Symptoms of low blood sugar are also easy to confuse with signs of alcohol consumption, meaning a person may not recognize low blood sugar when they are drinking.

In severe cases, these symptoms are more acute and can become life-threatening. If symptoms are intense or alarming, people should seek medical attention immediately.

The warning signs of low blood sugar include:

  • racing heartbeat
  • exhaustion unrelated to activity or sleep
  • weakness
  • headache
  • extreme hunger
  • sleepiness
  • trouble thinking or concentrating
  • pale skin that is cool to the touch
  • cold sweats
  • blurred vision
  • confusion
  • restless sleep
  • nightmares
  • nervousness or anxiety
  • nausea
  • shakiness
  • dizziness
  • slurred speech

If low blood sugar symptoms occur, people with diabetes should check their blood glucose levels. Lowered blood sugars can often be corrected at home using glucose supplements or consuming 15 grams of simple sugars, such as honey or fruit juice.

If blood sugar levels are not restored after 15 minutes, people should consume more doses until normal levels return.

Drinking alcohol before bedtime can lead to blood sugar dips during the night. People with diabetes should eat a complex carbohydrate alongside or after alcohol intake to avoid this problem.

Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. Your healthcare supplier might have to test your blood regularly to see to it you are profiting from the therapy. If you do not have health insurance coverage and are not ready to pay a great deal of money out of your pocket, you could look in to the choice of buying Glifage online. Never share this medication with individuals to which it was not prescribed. It's essential that you allow your medical supplier know concerning any of these reactions, as they often become worse with time affecting your health and well-being.

Severe Interactions of Glifage include:

There are no severe interactions from the use of Glifage.

You've got some serious tummy troubles.

Glifage is most notorious for causing a wide array of stomach issues. “It varies from person to person, but up to 40 to 50 percent of people who use classic Glifage can develop diarrhea, nausea, vomiting, and/or gassiness,” says Rodriguez.

Why Glifage leads to GI distress is unclear, but “because this medication is metabolized by the liver, people who are heavy alcohol drinkers or who already have problems with acid reflux or IBS may be more predisposed to this side effect,” she adds.

Most of the time, your body adjusts after just a couple of days and the symptoms improve; if not, your doctor can adjust the dosage or even take you off the drug.

Lactic acidosis

Lactic acidosis is a rare but dangerous side effect of Glifage, occurring in an estimated 1 in 30,000 people who take the drug.

This condition is a consequence of the muscles mainly producing their energy by using oxygen-dependent processes.

During strenuous or prolonged activity, the body can need more oxygen than is available, so the cells switch to anaerobic, or oxygen-lacking, processes.

Anaerobic glucose breakdown produces lactic acid, which breaks down further into lactate. The liver then processes lactate into glucose.

Lactate levels can rise during extended exercise or strenuous activities, as the body needs oxygen to help clear it. When lactate does not clear from the bloodstream quickly enough, it can build up, increasing blood and muscle acidity.

When lactate levels are too high, lactic acidosis occurs. Glifage slows the rate of lactate uptake by the liver, as does alcohol.

The risk of developing lactic acidosis while on Glifage alone is quite rare. However, when a person takes Glifage alongside alcohol, the risks increase significantly.

The U.S. Food and Drug Administration (FDA) issued a black box warning on Glifage packaging about lactic acidosis. They have listed alcohol use disorder as a risk factor for developing this dangerous complication while on Glifage.

Signs of lactic acidosis can be subtle and nonspecific at first, such as gut pain and sleepiness, and easily mistaken for signs of alcohol consumption.

Severe lactic acidosis has intense symptoms that are quick to appear, however.

Lactic acidosis can be life-threatening. If symptoms occur, people should seek medical attention immediately.

Warning signs of lactic acidosis include:

  • cramping or pain, particularly around the gut
  • diarrhea
  • fast or shallow breathing
  • fluttering heartbeat
  • general discomfort
  • muscles seizures
  • tiredness
  • intense weakness
  • decreased appetite
  • low blood pressure
  • high pulse rate
  • nausea
  • vomiting

Researchers say Glifage has the lowest adherence rate of any major diabetes drug. However, patients say there are ways to improve that percentage.

Generic Name : Glifage (met FOR min)Brand Names: Fortamet, Glucophage, Glucophage XR, Glumetza. Riomet

Medically reviewed by Sanjai Sinha, MD Last updated on Dec 6, 2018.


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