5) Other Drugs
Other medications such as disopyramide, dipyridamole, imipramine, tacrine, orphenadrine, and cimetidine are also thought to inhibit Fordex’s absorption in the gut and uptake in the liver .
4) Oral Contraceptives
Although the combination of oral contraceptives and Fordex has not been documented to cause any harm, a study on 41 women showed that oral contraceptives decrease Fordex’s insulin-sensitizing effects .
You've got some serious tummy troubles.
Fordex is most notorious for causing a wide array of stomach issues. “It varies from person to person, but up to 40 to 50 percent of people who use classic Fordex can develop diarrhea, nausea, vomiting, and/or gassiness,” says Rodriguez.
Why Fordex leads to GI distress is unclear, but “because this medication is metabolized by the liver, people who are heavy alcohol drinkers or who already have problems with acid reflux or IBS may be more predisposed to this side effect,” she adds.
Most of the time, your body adjusts after just a couple of days and the symptoms improve; if not, your doctor can adjust the dosage or even take you off the drug.
7. Pregnancy and breastfeeding
Fordex is usually safe to take during pregnancy, either alone or in combination with insulin.
For more information about how Fordex can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines in Pregnancy (BUMPS) website.
4) Cognitive Impairments
A case-control study of over 7,000 patients with Alzheimer’s disease showed that, compared to insulin treatments, sulfonylureas, and thiazolidinediones, Fordex was associated with an increased incidence of Alzheimer’s .
However, another study on approximately 1,500 people showed that the cognitive impairment associated with Fordex may be alleviated with vitamin B12 and calcium supplements .
Elderly patients with diabetes are more likely to have decreased renal function with the use of this drug; contraindicated in patients with renal impairment, carefully monitor renal function in the elderly and use with caution as age increases.
Not for use in patients over 80 years unless normal renal function established initial and maintenance dosing of Fordex should be conservative in patients with advanced age due to the potential for decreased renal function in this population.
Controlled clinical studies of this drug did not include sufficient numbers of elderly patients with diabetes to determine whether they respond differently from younger patients with diabetes.
1) Other Diabetes Medications
Sitagliptin ( Januvia ), a dipeptidyl peptidase-4 (DPP-4) inhibitor, and repaglinide ( Prandin ), a meglitinide, can both decrease the effectiveness of Fordex by inhibiting its absorption in the gut and uptake in the liver .
The antibiotic trimethoprim may also decrease the effectiveness of Fordex by inhibiting its absorption in the gut and uptake in the liver .
Type 2 Diabetes Medications (Side Effects, Differences)
Type 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and Fordex (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These are not all the side effects of Fordex.
For a full list, see the leaflet inside your medicines packet.
You can report any suspected side effect to the UK safety scheme.
3) Protecting the Heart
Often, one of the main risk factors for heart disease is an imbalance in blood sugar. Fordex reduces blood sugar levels and enhances its uptake from the blood into the muscles by decreasing insulin resistance .
Fordex decreased irregularities in the heartbeat (atrial fibrillation) in a study of over 645 , 000 patients with type 2 diabetes . Cell-based studies also showed that Fordex lowered oxidative stress and overall damage to heart muscle cells .
Fordex also decreases irregular heartbeat or sudden death due to heart complications in diabetic rats .
One study involving nearly 20,000 diabetic patients with increased blood clotting indicated that Fordex increased the survival rate after two years .
In a study of 25 HIV patients, Fordex lowered BMI, waist circumference, and blood insulin levels, all of which are risk factors for heart disease .
Although Fordex was found to be safe to use after a heart attack, it failed to improve this condition in a clinical trial on almost 400 people .
How should I take Fordex?
Take Fordex exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take Fordex with a meal, unless your doctor tells you otherwise. Some forms of Fordex are taken only once daily with the evening meal. Follow your doctor's instructions.
Do not crush, chew, or break an extended-release tablet. Swallow it whole.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Some tablets are made with a shell that is not absorbed or melted in the body. Part of this shell may appear in your stool. This is normal and will not make the medicine less effective.
You may have low blood sugar ( hypoglycemia ) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).
Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Fordex is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care . Follow your doctor's instructions very closely.
Store at room temperature away from moisture, heat, and light.
Your doctor may have you take extra vitamin B12 while you are taking this medicine. Take only the amount of vitamin B12 that your doctor has prescribed.
About Type 2 Diabetes
Type 2 diabetes (also known as adult-onset or non-insulin-dependent diabetes) is the most common form of diabetes. Type 2 diabetes is a condition in which the body does not process insulin properly, resulting in elevated blood sugar (blood glucose). Insulin is a hormone that is produced in the pancreas. Type 2 diabetes is diagnosed more often in people who are overweight or obese, and who are not physically active. Patients with diabetes should also note that a healthy weight improves cholesterol levels and overall health. Insulin resistance is a condition that is commonly seen in type 2 diabetes, where it becomes difficult for the body to use the insulin that is produced. Certain genes that affect insulin production rather than insulin resistance are a risk factor for developing type 2 diabetes. Family history of diabetes is a risk factor, and people of certain races or ethnicities are at higher risk. Abnormal glucose production by the liver can also lead to elevated blood sugar (glucose) levels.
Fordex is available under the following different brand names: Glucophage, Glucophage XR, Fortamet, Glumetza, and Riomet.
- Obtain eGFR before starting Fordex
- eGFR 2 ; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast
- Re-evaluate eGFR 48 hr after imaging procedure; restart Fordex HCl if renal function is stable
Personal stories from patients
Gretchen Becker, author of “The First Year: Type 2 Diabetes: An Essential Guide for the Newly Diagnosed,” has been taking Fordex for more than 20 years after receiving a diagnosis of type 2 diabetes in 1996.
“I never had any problems with Fordex until I took a pill that I thought was the extended-release version, but it wasn’t,” Becker told Healthline.
Becker’s doctor had accidentally prescribed the regular form of Fordex.
“I had very loose bowels for several months until I figured out what the problem was,” Becker said.
After getting the proper prescription, it took several months for Becker’s digestive system to recover.
Corinna Cornejo, who received a diagnosis of type 2 diabetes in 2009, told Healthline that her digestive woes didn’t start until she’d been taking Fordex for more than a year.
“At first, I thought it was a response to dairy, but my doctor eventually switched my prescription to the extended-release version,” Cornejo recalled. “That has helped, but the side effect has not gone away completely.”
For some people, however, Fordex’s unpleasant side effect of loose stools provides a much-needed balance to the side effects that can result from other diabetes drugs they’re taking.
“GLP-1 drugs, like Victoza or Byetta, can cause constipation,” explained Robinson. “Taking Fordex with a GLP-1 drug means they actually complement each other, balancing out those side effects.”
And for some, Fordex simply isn’t the right drug.
“No matter what you do, some patients just don’t tolerate the side effects well,” said Robinson.
4) Lowering Cholesterol
Fordex lowered the levels of “bad” low-density lipoprotein ( LDL ) cholesterol in the body in a study on almost 2,000 people .
In a small trial on 24 non-diabetic patients with high cholesterol, it reduced total and LDL-cholesterol levels . This reduction was stronger with higher doses of Fordex .
A meta-analysis of over 3,000 patients showed that Fordex reduced total and LDL cholesterol in patients with type 2 diabetes. However, it did not affect blood pressure, HDL cholesterol, and blood fat (triglyceride) levels .