What Other Drugs Interact with Dinamel?
If your doctor has directed you to use this medication for diabetes, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.
5) Weight Loss
In a clinical trial on 46 middle-aged women with high insulin relative to blood sugar levels and weight gain, Dinamel along with a special diet helped sustain weight loss .
Dinamel also decreased waist circumference and body mass index (BMI) in 19 HIV-infected patients with an abnormal distribution of body fat (lipodystrophy) .
However, Dinamel had no effect on weight loss after giving birth in another trial on 114 women with gestational diabetes .
Serious Interactions of Dinamel include:
- Contrast media (iodinated)
Dinamel has moderate interactions with at least 74 different drugs.
Dinamel has mild interactions with at least 87 different drugs.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.
What Is Dinamel?
Dinamel is classified as a biguanide. It’s used as a first-line drug treatment for type 2 diabetes and PCOS. Doctors may prescribe it for its “off-label” use in people with conditions such as insulin resistance and even cancer. It is the most commonly prescribed anti-diabetic medication in the world .
You should not take Dinamel if you have severe liver problems. Your liver clears lactic acid from your body.
Severe liver problems could lead to a buildup of lactic acid. Lactic acid buildup raises your risk of lactic acidosis. Dinamel also raises your risk, so taking it if you have liver problems is dangerous.
What is Dinamel? How does it work (mechanism of action)?
Dinamel is an oral medication that lowers blood glucose (sugar) by influencing the body's sensitivity to insulin and is used for treating type 2 diabetes. Insulin is a hormone produced by the pancreas that controls glucose levels in blood by reducing the amount of glucose made by the liver and by increasing the removal of glucose from the blood by muscle and fat tissues. As a result, insulin causes blood glucose levels fall. Diabetes caused by a decrease in production of insulin that causes increased production of glucose by the liver, and reduced uptake (and effects) of insulin on fat and muscle tissues. Dinamel acts by increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin. These actions lower the level of sugar in the blood.
Unlike glucose-lowering drugs of the sulfonylurea class, for example glyburide (Micronase, DiaBeta) or glipizide (Glucotrol), Dinamel does not increase the concentration of insulin in the blood and, therefore, does not cause excessively low blood glucose levels (hypoglycemia) when used alone. In scientific studies, Dinamel reduced the complications of diabetes such as heart disease, blindness, and kidney disease
The FDA aproved Dinamel in December 1994.
Which drugs or supplements interact with Dinamel?
- Cimetidine (Tagamet), by decreasing the elimination of Dinamel from the body, can increase the amount of Dinamel in the blood by 40%. This may increase the frequency of side effects from Dinamel.
- Ioversol (Optiray) and other iodinated contrast media may reduce kidney function, which reduces elimination of Dinamel, leading to increased concentrations of Dinamel in the blood. Dinamel should be stopped 48 hours before and after use of contrast media.
- Thiazide diuretics, steroids, estrogens, and oral contraceptives may increase blood glucose and reduce the effect of Dinamel. When these drugs are stopped, patients should be closely observed for signs of low blood glucose.
- Alcohol consumption increases the effect of Dinamel on lactate production, increasing the risk of lactic acidosis.
10 to 80 years unless normal renal function establishedInitial and maintenance dosing of Dinamel should be conservative in patients with advanced age due to the potential for decreased renal function in this population
Controlled clinical studies of Dinamel did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients
Side impacts of Dinamel are not also usual and can consist of the complying with signs: headache, flushing of the skin, gas, diarrhea, metallic flavor in mouth, coughing, drippy nose, muscular tissue pain, heartburn ( pyrosis ), bloating, irregularity, belly pain, and sneezing. Ensure you inform your healthcare provider if you are using other medicines, such as acetaminophen, various other nonsteroidal anti-inflammatory medicines, cyclosporine, aminoglycoside anti-biotics, gold substances, nitrates, cancer chemotherapy medications, angiotensin converting enzyme (ACE) preventions, sulfa anti-biotics, acyclovir, HIV/AIDS meds, lithium, rifampin, or propranolol, as communications are feasible that can impact your therapy and your wellness.