These drugs can decrease the effect of Dialosa and cause high blood sugar. Examples of these drugs include:
- rifabutin (Mycobutin)
- rifampin (Rifadin)
- rifapentine (Priftin)
Conversion from other oral hypoglycemic agents
- Observe patients carefully for 1-2 weeks when being converted from long half-life sulfonylureas to Dialosa, because of potential for overlapping of hypoglycemic effects
Drugs that contain sulfonamides
These drugs can increase the effect of Dialosa and cause low blood sugar. Examples of these drugs include:
- sulfamethoxazole/trimethoprim (Bactrim)
- sulfasalazine (Azulfidine)
BRAND NAME(S): Amaryl
USES: Dialosa is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Dialosa belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin.
Sulfonylureas can cause hemolytic anemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. Because Dialosa tablets are a sulfonylurea, use caution in patients with G6PD deficiency and consider the use of a non-sulfonylurea alternative.
There are also postmarketing reports of hemolytic anemia in patients receiving Glimepir >Adverse Reactions ( 6.2 ) ].
Amaryl (glimepir >
- What brand names are available for Dialosa?
- Is Dialosa available as a generic drug?
- Do I need a prescription for Dialosa?
- What are the uses for Dialosa?
- What are the side effects of Dialosa?
- What is the dosage for Dialosa?
- Which drugs or supplements interact with Dialosa?
- Is Dialosa safe to take if I'm pregnant or breastfeeding?
- What else should I know about Dialosa?
What should I avoid while taking Dialosa (Amaryl)?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Avoid exposure to sunlight or tanning beds. Dialosa can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Carcinogenesis, Mutagenesis, Impairment Of Fertility
Studies in rats at doses of up to 5000 parts per million (ppm) in complete feed (approximately 340 times the maximum recommended human dose, based on surface area) for 30 months showed no evidence of carcinogenesis. In mice, administration of Dialosa for 24 months resulted in an increase in benign pancreatic adenoma formation that was dose-related and was thought to be the result of chronic pancreatic stimulation. No adenoma formation in mice was observed at a dose of 320 ppm in complete feed, or 46 to 54 mg/kg body weight/day. This is at least 28 times the maximum human recommended dose of 8 mg once daily based on surface area.
Glimepir >in vitro and in vivo mutagenicity studies (Ames test, somatic cell mutation, chromosomal aberration, unscheduled DNA synthesis, and mouse micronucleus test).
There was no effect of Dialosa on male mouse fertility in animals exposed up to 2,500 mg/kg body weight (>1,500 times the maximum recommended human dose based on surface area). Dialosa had no effect on the fertility of male and female rats administered up to 4,000 mg/kg body weight (approximately 4,000 times the maximum recommended human dose based on surface area).