Apo-Glim tablets

Apo-Glim

  • Active Ingredient: Glimepiride
  • 4 mg, 2 mg, 1 mg
Buy Now

What is Apo-Glim?

The active ingredient of Apo-Glim brand is glimepiride. Glimepiride is an oral diabetes medicine that helps control blood sugar levels. Glimepiride tablets contain the active ingredient Glimepiride and the following inactive ingredients:lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate (potato). In addition, the 2 mgand 4 mg tablets contain D&C Yellow No. 10 Aluminum Lake and the 4 mg also contains D&C Red No. 27 Aluminum Lake.

Used for

Apo-Glim is used to treat diseases such as: Diabetes, Type 2.

Side Effect

Possible side effects of Apo-Glim include: Lack or loss of strength; nausea and vomiting; red skin lesions, often with a purple center; itching; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; blurred vision; chest pain; back, leg, or stomach pains.

How to Buy Apo-Glim tablets online?

To buy Apo-Glim online - just click on the "Buy Now" button in the top and follow on to our shop. Payment and Order takes a couple of minutes, and all steps are obvious. We don't require a medical prescription plus also we have many methods of payment. Considering all the details of fast shipping and confidentiality, then you may read on the applicable pages on the links in the navigation menu.

Related Medications

Losarquilab

Losarquilab 50mg, 25mg

losartan

More info

Psycholanz

Psycholanz 50mg, 25mg

losartan

More info

Docmetformi

Docmetformi 850mg, 500mg

metformin

More info

Higlucem

Higlucem 45mg, 30mg, 15mg

pioglitazone

More info

What other drugs will affect Apo-Glim (Amaryl)?

Apo-Glim may not work as well when you use other medicines at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

If you also take colesevelam, take your Apo-Glim dose at least 4 hours before you take colesevelam.

Other drugs may affect Apo-Glim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Blood pressure and heart drugs (angiotensin-converting enzyme inhibitors)

These drugs can increase the effect of Apo-Glim and cause low blood sugar. Examples of these drugs include:

  • benazepril (Lotensin)
  • captopril (Capoten)
  • enalapril (Vasotec)
  • enalaprilat
  • fosinopril (Monopril)
  • lisinopril (Prinivil)
  • moexipril (Univasc)
  • perindopril (Aceon)
  • quinapril (Accupril)
  • ramipril (Altace)
  • trandolapril (Mavik)

Hidden costs

Besides the drug, you’ll need to purchase the following:

  • sterile alcohol wipes
  • lancing device and lancets
  • blood sugar test strips
  • blood glucose monitor
  • needle container for safe disposal of lancets

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

  • Low blood sugar warning: Apo-Glim can cause low blood sugar (hypoglycemia). Symptoms may include:
    • trembling or shaking
    • nervousness or anxiety
    • irritability
    • sweating
    • lightheadedness or dizziness
    • headache
    • fast heart rate or palpitations
    • intense hunger
    • fatigue or tiredness
  • urinating more often than usual
  • feeling very thirsty
  • feeling very hungry even though you’re eating
  • extreme fatigue
  • blurred vision
  • cuts or bruises that are slow to heal
  • tingling, pain, or numbness in your hands or feet

Fatal heart problems warning: Apo-Glim may increase your risk of fatal heart problems compared to treatment with diet alone or diet plus insulin. Ask your doctor if this drug is right for you.

This drug comes with several warnings.

What should I avoid while taking Apo-Glim (Amaryl)?

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Avoid exposure to sunlight or tanning beds. Apo-Glim can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Nursing Mothers

It is not known whether AMARYL is excreted in human milk. During pre- and post-natal studies in rats, significant concentrations of Apo-Glim were present in breast milk and the serum of the pups. Offspring of rats exposed to high levels of Apo-Glim during pregnancy and lactation developed skeletal deformities consisting of shortening, thickening, and bending of the humerus during the postnatal period. These skeletal deformations were determined to be the result of nursing from mothers exposed to Apo-Glim. Based on these animal data and the potential for hypoglycemia in a nursing infant, a decision should be made whether to discontinue nursing or discontinue AMARYL, taking into account the importance of AMARYL to the mother.

Summary

Amaryl (Apo-Glim) is a drug prescribed to treat individuals with type 2 diabetes that cannot be controlled by a strict diabetes diet. Side effects include:

Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.

Is Apo-Glim safe to take if I'm pregnant or breastfeeding?

  • In animal studies, Apo-Glim and other sulfonylureas were associated with a higher risk of fetal death. However, there have been no good studies in women. Abnormal blood sugar concentrations (high or low) during pregnancy increase the risk of abnormalities in the fetus. Therefore, physicians must carefully weigh the benefits and risks of sulfonylurea treatment during pregnancy. Insulin is the drug of choice for treating diabetes in pregnant women.
  • It is not known if Apo-Glim is excreted in breast milk like other sulfonylureas. Because of the risk of low blood sugar in the infant, it is recommended that Apo-Glim be discontinued in nursing mothers. If therapy other than diet and exercise is needed, insulin is preferred.

7.3 Cytochrome P450 2C9 Interactions

There may be an interaction between Apo-Glim and inhibitors (e.g., fluconazole) and inducers (e.g., rifampin) of cytochrome P450 2C9. Fluconazole may inhibit the metabolism of Apo-Glim, causing increased plasma concentrations of Apo-Glim which may lead to hypoglycemia. Rifampin may induce the metabolism of Apo-Glim, causing decreased plasma concentrations of Apo-Glim which may lead to worsening glycemic control.

How should I take Apo-Glim (Amaryl)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Apo-Glim is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Apo-Glim with a full glass of water.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Apo-Glim is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

How it works

Apo-Glim belongs to a class of drugs called sulfonylureas. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Apo-Glim helps your pancreas to release insulin. Insulin is a chemical that your body makes to move sugar (glucose) from your bloodstream into your cells. Once the sugar enters your cells, they can use it as fuel for your body.

With type 2 diabetes, your body doesn’t make enough insulin, or it can't properly use the insulin that it makes, so the sugar stays in your bloodstream. This causes high blood sugar levels (hyperglycemia).

Apo-Glim oral tablet doesn’t cause drowsiness, but it can cause other side effects.

Cytochrome P450 2C9 Interactions

There may be an interaction between Apo-Glim and inhibitors (e.g., fluconazole) and inducers (e.g., rifampin) of cytochrome P450 2C9. Fluconazole may inhibit the metabolism of Apo-Glim, causing increased plasma concentrations of Apo-Glim which may lead to hypoglycemia. Rifampin may induce the metabolism of Apo-Glim, causing decreased plasma concentrations of Apo-Glim which may lead to worsening glycemic control.

Dictionary Entries near Apo-Glim

Cite this Entry

“Apo-Glim.” The Merriam-Webster.com Medical Dictionary, Merriam-Webster Inc., https://www.merriam-webster.com/medical/Apo-Glim. Accessed 27 December 2019.

Which drugs or supplements interact with Apo-Glim?

  • Some medications when given with Apo-Glim may reduce its ability to lower blood sugar. These drugs include diuretics, for example, hydrochlorothiazide (Microzide, and many combinations with other drugs), loop diuretics (for example, furosemide ), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), colesevelam (Welchol), danazol and somatropin (Genotropin). Rifampin increases the breakdown of Apo-Glim by liver enzymes. This might reduce the effect of Apo-Glim and result in higher levels of sugar in the blood.
  • Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar. Additionally, they can directly reverse the sugar-lowering effect of sulfonylureas and render them less effective. Beta blockers also can blunt some of the body's protective responses to low blood sugar, thus making it difficult for patients to recognize reactions due to low blood sugar (hypoglycemia).
  • Certain drugs when given with Apo-Glim may increase the risk of low blood sugar (hypoglycemia). These include nonsteroidal anti-inflammatory drugs or NSAIDs (for example ibuprofen), sulfa drugs, warfarin (Coumadin), miconazole (Oravig), fluconazole (Diflucan), chloramphenicol, cimetidine (Tagamet HB), ranitidine (Zantac), clarithromycin (Biaxin), MAO Inhibitors (for example, isocarboxazid and phenelzine ), mifepristone (Mifeprex), probenecid, quinolone antibiotics and selective serotonin reuptake inhibitors or SSRIs (for example paroxetine , fluoxetine and sertraline ) and voriconazole (Vfend). Blood sugar should be closely monitored when interacting drugs are given with Apo-Glim.
  • Combination Apo-Glim with insulin and use in patients with congestive heart failure may increase risk of other heart related side effects.

Apo-Glim (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation.

How should I take Apo-Glim?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Apo-Glim is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Apo-Glim with a full glass of water.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Apo-Glim is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Apo-Glim is completely metabolized by oxidative biotransformation after either an intravenous or oral dose. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2). Cytochrome P450 2C9 is involved in the biotransformation of Apo-Glim to M1. M1 is further metabolized to M2 by one or several cytosolic enzymes. M2 is inactive. In animals, M1 possesses about one-third of the pharmacological activity of Apo-Glim, but it is unclear whether M1 results in clinically meaningful effects on blood glucose in humans.


© Copyright 2017-2020 - rootsdentclinic.com - We Care About You!

Sitemap