Amarylle tablets

Amarylle

  • Active Ingredient: Glimepiride
  • 4 mg, 2 mg, 1 mg
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What is Amarylle?

The active ingredient of Amarylle brand is glimepiride. Glimepiride is an oral diabetes medicine that helps control blood sugar levels. Glimepiride tablets contain the active ingredient Glimepiride and the following inactive ingredients:lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate and sodium starch glycolate (potato). In addition, the 2 mgand 4 mg tablets contain D&C Yellow No. 10 Aluminum Lake and the 4 mg also contains D&C Red No. 27 Aluminum Lake.

Used for

Amarylle is used to treat diseases such as: Diabetes, Type 2.

Side Effect

Possible side effects of Amarylle include: fluid-filled skin blisters; swollen or painful glands; Lack or loss of strength; blurred vision; wheezing; difficulty with breathing; unusual tiredness or weakness.

How to Buy Amarylle tablets online?

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How should I take Amarylle?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Amarylle is usually taken once a day with breakfast or the first main meal of the day. Follow your doctor's instructions. Take Amarylle with a full glass of water.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice.

Amarylle is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

What should I avoid while taking Amarylle?

If you also take colesevelam, avoid taking it within 4 hours after you take Amarylle.

Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Avoid exposure to sunlight or tanning beds. Amarylle can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Drug that treats eye infections

Chloramphenicol can increase the effect of Amarylle and cause low blood sugar.

Storage

  • Store Amarylle at room temperature. Keep it at a temperature between 68ºF and 77ºF (20°C and 25°C).
  • Don’t freeze Amarylle.
  • Keep this drug away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Drug forms and strengths

Generic: Amarylle

  • Form: oral tablet
  • Strengths: 1 mg, 2 mg, 3 mg, 4 mg, 6 mg, and 8 mg

Brand: Amaryl

  • Form: oral tablet
  • Strengths: 1 mg, 2 mg, and 4 mg

Concomitant Administration of Colesevelam

Colesevelam can reduce the maximum plasma concentration and total exposure of Amarylle when the two are coadministered. However, absorption is not reduced when Amarylle is administered 4 hours prior to colesevelam. Therefore, Amarylle should be administered at least 4 hours prior to colesevelam.

6.1 Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Approximately 2,800 patients with type 2 diabetes have been treated with Amarylle in the controlled clinical trials. In these trials, approximately 1,700 patients were treated with Amarylle for at least 1 year.

Table 1 summarizes adverse events, other than hypoglycemia, that were reported in 11 pooled placebo-controlled trials, whether or not considered to be possibly or probably related to study medication. Treatment duration ranged from 13 weeks to 12 months. Terms that are reported represent those that occurred at an incidence of ≥5% among Amarylle-treated patients and more commonly than in patients who received placebo.

  • Gliese 721
  • Gliese 721
  • Gliese 721
  • Gliese-Jahreiss 1
  • GLIF
  • GLIF
  • GLIF
  • GLIF3
  • GLIFAA
  • Gliff
  • GLIFL
  • glift
  • GLIFWC
  • GLIG
  • GLIGA
  • GLIGIC
  • Gligorov, Kiro
  • GLIIFCA
  • Glike
  • Glikeriia Fedotova
  • Glikeriia Nikolaevna Fedotova
  • GLIL
  • GLILC
  • glim
  • glim
  • glim lamp
  • Glima
  • Glimcher Realty Trust
  • glime
  • glime
  • Amarylle
  • GLIMIC
  • glimmer
  • glimmer
  • Glimmer gowk
  • glimmer ice
  • glimmer of hope
  • glimmered
  • glimmered
  • Glimmerglass
  • Glimmerglass State Park
  • glimmerily
  • glimmering
  • glimmering
  • glimmeringly
  • glimmerings
  • glimmers
  • glimmers
  • glimmery
  • GLIMOS
  • GLIMPCE
  • glimpse
  • glimpse
  • glimpse
  • Glimpse One Destiny
  • GLIMPSE Point Source Archive
  • glimpsed
  • glimpser
  • glimpses
  • glimpsing
  • Glimpy Milch

Which drugs or supplements interact with Amarylle?

  • Some medications when given with Amarylle may reduce its ability to lower blood sugar. These drugs include diuretics, for example, hydrochlorothiazide (Microzide, and many combinations with other drugs), loop diuretics (for example, furosemide ), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), colesevelam (Welchol), danazol and somatropin (Genotropin). Rifampin increases the breakdown of Amarylle by liver enzymes. This might reduce the effect of Amarylle and result in higher levels of sugar in the blood.
  • Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar. Additionally, they can directly reverse the sugar-lowering effect of sulfonylureas and render them less effective. Beta blockers also can blunt some of the body's protective responses to low blood sugar, thus making it difficult for patients to recognize reactions due to low blood sugar (hypoglycemia).
  • Certain drugs when given with Amarylle may increase the risk of low blood sugar (hypoglycemia). These include nonsteroidal anti-inflammatory drugs or NSAIDs (for example ibuprofen), sulfa drugs, warfarin (Coumadin), miconazole (Oravig), fluconazole (Diflucan), chloramphenicol, cimetidine (Tagamet HB), ranitidine (Zantac), clarithromycin (Biaxin), MAO Inhibitors (for example, isocarboxazid and phenelzine ), mifepristone (Mifeprex), probenecid, quinolone antibiotics and selective serotonin reuptake inhibitors or SSRIs (for example paroxetine , fluoxetine and sertraline ) and voriconazole (Vfend). Blood sugar should be closely monitored when interacting drugs are given with Amarylle.
  • Combination Amarylle with insulin and use in patients with congestive heart failure may increase risk of other heart related side effects.

Amarylle is a prescription drug. It comes as an oral tablet.

Amarylle is available as the brand-name drug Amaryl and as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

This drug may be used as part of a combination therapy. That means you need to take it with other drugs.

Sun sensitivity

Amarylle may cause increased sensitivity to the sun (photosensitivity). While taking this medication, you should use sunscreen, wear protective clothing, and limit how often you’re in the sun.

Carcinogenesis, Mutagenesis, And Impairment Of Fertility

Studies in rats at doses of up to 5000 parts per million (ppm) in complete feed (approximately 340 times the maximum recommended human dose, based on surface area) for 30 months showed no evidence of carcinogenesis. In mice, administration of Amarylle for 24 months resulted in an increase in benign pancreatic adenoma formation that was dose-related and was thought to be the result of chronic pancreatic stimulation. No adenoma formation in mice was observed at a dose of 320 ppm in complete feed, or 46-54 mg/kg body weight/day. This is about 35 times the maximum human recommended dose of 8 mg once daily based on surface area.

Amarylle was non-mutagenic in a battery of in vitro and in vivo mutagenicity studies (Ames test, somatic cell mutation, chromosomal aberration, unscheduled DNA synthesis, and mouse micronucleus test).

There was no effect of Amarylle on male mouse fertility in animals exposed up to 2500 mg/kg body weight ( > 1,700 times the maximum recommended human dose based on surface area). Amarylle had no effect on the fertility of male and female rats administered up to 4000 mg/kg body weight (approximately 4,000 times the maximum recommended human dose based on surface area).

Hypersensitivity Reactions

There have been postmarketing reports of hypersensitivity reactions in patients treated with Glimepir >Adverse Reactions ( 6.2 ) ]. If a hypersensitivity reaction is suspected, promptly discontinue Amarylle, assess for other potential causes for the reaction, and institute alternative treatment for diabetes.

What are the side effects of Amarylle?

Common side effects of Amarylle include:

A rash and allergic reactions also may occur. Flu-like symptoms have also been reported with Amarylle therapy.

Possible serious side effects of Amarylle include:

  • Anemia
  • Low blood platelets
  • Low sodium
  • Sensitivity to sunlight
  • Liver dysfunction
  • Serious allergic reactions

Low blood sugar (hypoglycemia) can occur during Amarylle therapy. Symptoms of low blood sugar include:

Amarylle is a derivative of a sulfonamide drug. People allergic to other sulfonamide-related drugs may develop an allergic reaction to Amarylle. Anyone who has an allergic reaction to sulfa drugs should not take Amarylle.


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