See also Warning section.
Sore throat, muscle pain, weight gain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating.
Adpas may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes/skin, persistent nausea/vomiting, stomach/abdominal pain.
Adpas does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise, or do not consume enough calories from food. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.
Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product.
Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
3. Who can and can't take Adpas
Adpas can be taken by adults (aged 18 years and older).
Adpas isn't suitable for some people. To make sure it's safe for you, tell your doctor if you:
- have had an allergic reaction to Adpas or any other medicines in the past
- have liver or heart problems
- have or have ever had bladder cancer or blood in your pee
- have illnesses caused by your diabetes, including macular oedema (a swelling at the back of your eye)
- have a condition such as osteoporosis or osteopenia that affects your bones
If you're over 75 years old, you may be more likely to break a bone or get heart failure. Talk to your doctor about whether Adpas is suitable for you.
- This medicine may cause or make heart failure worse. Tell your doctor if you have had heart failure. Do not take Adpas if you have moderate to severe heart failure or any signs of heart failure. You will be watched closely while starting Adpas and if your dose is raised. Call your doctor right away if you have swelling in the arms or legs, shortness of breath, trouble breathing, sudden weight gain, weight gain that is not normal, or you feel very tired.
How should this medicine be used?
Adpas comes as a tablet to take by mouth. It is usually taken once daily with or without meals. Take Adpas at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Adpas exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor may start you on a low dose of Adpas and gradually increase your dose.
Adpas controls type 2 diabetes but does not cure it. It may take 2 weeks for your blood sugar to decrease and 2 to 3 months for you to feel the full effect of Adpas. Continue to take Adpas even if you feel well. Do not stop taking Adpas without talking to your doctor.
Serious allergic reaction
It is possible to have a serious allergic reaction (anaphylaxis) to Adpas.
Immediate action required: Call 999 or go to A&E if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These are not all the side effects of Adpas. For a full list see the leaflet inside your medicines packet.
You can report any suspected side effect to the UK safety scheme.
What Is Adpas (Actos)?
Adpas is the generic form of the prescription drug known by the brand name Actos.
It's used along with diet and exercise to help lower blood sugar in people who have type 2 diabetes.
When you have type 2 diabetes, your body doesn't make or use the hormone insulin normally, so it can't control the amount of sugar, or glucose, in the blood.
Adpas is in a class of drugs known as thiazolidinediones.
It lowers blood-sugar levels by making the body's cells more sensitive to insulin, allowing them to take up more glucose from your blood.
Taking Adpas, along with adopting a healthy lifestyle, can decrease your risk of developing the serious or life-threatening complications of type 2 diabetes.
These may include cardiovascular diseases, such as heart attack, stroke, and problems related to blood circulation; nerve damage; kidney disease; or eye conditions.
The drug is manufactured by Takeda Pharmaceuticals, and was approved by the Food and Drug Administration (FDA) in 1999.
Missed Dose of Adpas
If you miss a dose of Adpas, and you remember that same day, take the missed dose as soon as you remember.
If you don't remember until the next day, don't take an extra pill. Just continue on your regular medication schedule.
Don't take more than one dose a day or double up to make up for a missed one.
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What Is Adpas and How Does It Work?
Adpas is a prescription drug indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings.
Adpas exerts its antihyperglycemic effect only in the presence of endogenous insulin. Adpas should not be used to treat type 1 diabetes or diabetic ketoacidosis, as it would not be effective in these settings.
Adpas is available under the following different brand names: Actos.
Dosages of Adpas:
Dosage Considerations – Should be Given as Follows:
- Indicated as monotherapy or with insulin or insulin secretagogues
- 15-30 mg orally with meal every daily initially; may increase dose by 15 mg with careful monitoring to 45 mg each day
- Monitor ALT at start of treatment, each month for 12 months, then every 3 months thereafter
- Coadministration with insulin secretagogue (sulfonylurea): Decrease insulin secretagogue dose
- Coadministration with insulin: Decrease insulin dose by 10-25%
- Coadministration with strong CYP2C8 inhibitors (gemfibrozil): Limit maximum Adpas dose to 15 mg daily
Not recommended for pediatric use
Adpas comes as a tablet and is typically taken by mouth once a day, with or without meals.
Your dosage will be based on your medical condition, response to treatment, and other drugs you're taking.
Try to take Adpas around the same time each day.
Your doctor might start you on a low dose and gradually increase it.
Follow the instructions on your prescription label carefully. Don't take more or less than is prescribed.
Common Side Effects of Adpas
Tell your doctor if any of the following side effects become severe or don't go away:
- Sore throat
- Muscle pain
- Sinus pain
- Weight gain
- Tooth problems
- Pain in the arms or legs