3) Protecting the Heart
Often, one of the main risk factors for heart disease is an imbalance in blood sugar. Adimet reduces blood sugar levels and enhances its uptake from the blood into the muscles by decreasing insulin resistance .
Adimet decreased irregularities in the heartbeat (atrial fibrillation) in a study of over 645 , 000 patients with type 2 diabetes . Cell-based studies also showed that Adimet lowered oxidative stress and overall damage to heart muscle cells .
Adimet also decreases irregular heartbeat or sudden death due to heart complications in diabetic rats .
One study involving nearly 20,000 diabetic patients with increased blood clotting indicated that Adimet increased the survival rate after two years .
In a study of 25 HIV patients, Adimet lowered BMI, waist circumference, and blood insulin levels, all of which are risk factors for heart disease .
Although Adimet was found to be safe to use after a heart attack, it failed to improve this condition in a clinical trial on almost 400 people .
Adimet can decrease the levels of vitamin B-12 in your body. In rare cases, this can cause anemia or low levels of red blood cells. If you don’t get much vitamin B-12 or calcium through your diet, you may be at higher risk of very low vitamin B-12 levels.
Your vitamin B-12 levels can improve if you stop taking Adimet or take vitamin B-12 supplements. Do not stop taking Adimet without talking to your doctor.
The more common symptoms of anemia include:
If you think you may have anemia, make an appointment with your doctor to have your red blood cell levels checked.
Adimet has moderate interactions with at least 74 different drugs.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.
See also Warning section.
Before taking this medication, tell your doctor or pharmacist if you are allergic to Adimet; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), kidney disease, liver disease.
Before having surgery or any X-ray/scanning procedure using iodinated contrast, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may need to stop this medication for a short time for the surgery/procedure. Ask your doctor or dentist for instructions before your surgery/procedure.
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
Limit alcohol while using this medication because it can increase your risk of lactic acidosis and developing low blood sugar.
High fever, "water pills" (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.
It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because increased stress may require a change in your treatment plan, medications, or blood sugar testing.
Older adults may be at greater risk for side effects such as low blood sugar or lactic acidosis.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Your doctor may direct you to use insulin instead of this product during your pregnancy. Follow your doctor's instructions carefully.
Adimet can cause changes in the menstrual cycle (promote ovulation) and increase the risk of becoming pregnant. Consult your doctor or pharmacist about the use of reliable birth control while using this medication.
Adimet passes into breast milk in small amounts. Consult your doctor before breast-feeding.
2. Key facts
- Adimet works by reducing the amount of sugar your liver releases into your blood. It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood.
- It's best to take Adimet with a meal to reduce the side effects.
- The most common side effects are feeling and being sick, diarrhoea, stomach ache and going off your food.
- Adimet does not cause weight gain, unlike some other diabetes medicines.
- Adimet may also be called by the brand names Bolamyn, Diagemet, Glucient, Glucophage and Metabet. Liquid Adimet is called by the brand name Riomet.
8. Cautions with other medicines
There are some medicines that interfere with the way Adimet works.
If you're taking any of the following medicines, your blood sugar levels may need to be checked more often and your dose adjusted:
- steroid tablets, such as prednisolone
- tablets that make you pee more (diuretics), such as furosemide
- medicines to treat heart problems and high blood pressure
- male and female hormones, such as testosterone, oestrogen and progesterone
- other diabetes medicines
Some women might need a small adjustment in their Adimet dose after starting contraceptive pills. That's because contraceptive pills change how your body handles sugar.
2) PCOS Symptoms
Polycystic ovarian syndrome (PCOS) is a hormonal disorder often aggravated by obesity and insulin resistance. Adimet treats PCOS symptoms, such as irregular ovulation or menstrual cycles, and the excess of insulin in the body .
It has also been shown to treat other PCOS symptoms by reducing BMI and testosterone levels .
Furthermore, Adimet assists fertility and increases the chance of successful pregnancy and reduces the risk of early miscarriage, gestational diabetes, and inflammation associated with PCOS .
Adimet helps regulate blood sugars, and so it can cause hypoglycemia, or low blood sugars.
This can happen if someone takes too large a dose, maintains a poor diet, or consumes too much alcohol.
Alcohol also causes dips in blood sugar levels, and so when combined with Adimet, the risk of hypoglycemia is much higher.
According to the American Diabetes Association, blood glucose levels below 70 milligrams per deciliter are too low for most people.
Symptoms in mild hypoglycemic cases, such as headaches, tiredness, and hunger, are usually too vague to be a warning sign.
Symptoms of low blood sugar are also easy to confuse with signs of alcohol consumption, meaning a person may not recognize low blood sugar when they are drinking.
In severe cases, these symptoms are more acute and can become life-threatening. If symptoms are intense or alarming, people should seek medical attention immediately.
The warning signs of low blood sugar include:
- racing heartbeat
- exhaustion unrelated to activity or sleep
- extreme hunger
- trouble thinking or concentrating
- pale skin that is cool to the touch
- cold sweats
- blurred vision
- restless sleep
- nervousness or anxiety
- slurred speech
If low blood sugar symptoms occur, people with diabetes should check their blood glucose levels. Lowered blood sugars can often be corrected at home using glucose supplements or consuming 15 grams of simple sugars, such as honey or fruit juice.
If blood sugar levels are not restored after 15 minutes, people should consume more doses until normal levels return.
Drinking alcohol before bedtime can lead to blood sugar dips during the night. People with diabetes should eat a complex carbohydrate alongside or after alcohol intake to avoid this problem.
Why is this medication prescribed?
Adimet is used alone or with other medications, including insulin, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Adimet is in a class of drugs called biguanides. Adimet helps to control the amount of glucose (sugar) in your blood. It decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Adimet also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Adimet is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).
Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
4) Cognitive Impairments
A case-control study of over 7,000 patients with Alzheimer’s disease showed that, compared to insulin treatments, sulfonylureas, and thiazolidinediones, Adimet was associated with an increased incidence of Alzheimer’s .
However, another study on approximately 1,500 people showed that the cognitive impairment associated with Adimet may be alleviated with vitamin B12 and calcium supplements .
Pregnancy and Lactation
Use in pregnancy may be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
Not recommended when lactating as Adimet enters breast milk.
How to use Adimet HCL
Read the Patient Information Leaflet if available from your pharmacist before you start taking Adimet and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Take this medication by mouth as directed by your doctor, usually 1-3 times a day with meals. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects (such as upset stomach), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping/continuing the old drug and starting Adimet.
Check your blood sugar regularly as directed by your doctor. Keep track of the results, and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your dosage/treatment may need to be changed.
Your head is pounding.
Adimet doesn't typically cause blood pressure to plummet and lead to hypoglycemia, but it can—and that can cause headaches. "Adimet alone should not cause hypoglycemia,” Rodriguez explains. But “when we see headaches, it’s usually in a patient on a combination of medications that can drop blood sugars too low.” If you’re experiencing an abnormal amount of headaches or an abnormal type of headache, talk to your doctor about adjusting your medications.