Tryptizol tablets

Tryptizol

  • Active Ingredient: Amitriptyline
  • 50 mg, 25 mg
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What is Tryptizol?

The active ingredient of Tryptizol brand is amitriptyline. Amitriptyline is a tricyclic antidepressant. Amitriptyline affects chemicals in the brain that may be unbalanced in people with depression. Amitriptyline HCl, a dibenzocycloheptadiene derivative, has a molecular weight of 313.87. It is a white, odorless, crystalline compound which is freely soluble in water. Each tablet, for oral administration, contains 10 mg, 25 mg, 50 mg, 75 mg, 100 mg or 150 mg of Amitriptyline hydrochloride. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, talc, polyethylene glycol, and titanium dioxide; 10 mg contains D&C Red No. 27 Aluminum Lake, FD&C Yellow No. 6 Aluminum Lake, and FD&C Blue No. 1 Aluminum Lake; 25 mg contains D&C Yellow No. 10 Aluminum Lake, FD&C Blue No. 1 Aluminum Lake, and FD&C Red No. 40 Aluminum Lake; 50 mg contains FD&C Yellow No. 5 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, and FD&C Red No. 40 Aluminum Lake; 75 mg contains D&C Red No. 7 Lake, and FD&C Blue No. 1 Aluminum Lake; 100 mg and 150 mg contain D&C Red No. 30 Lake, and D&C Yellow No. 10 Aluminum Lake.

Used for

Tryptizol is used to treat diseases such as: Anxiety and Stress, Burning Mouth Syndrome, Chronic Myofascial Pain, Cough, Cyclic Vomiting Syndrome, Depression, Dysautonomia, Fibromyalgia, Hyperhidrosis, Insomnia, Interstitial Cystitis, Irritable Bowel Syndrome, Migraine Prevention, Neurotic Depression, Pain, Persistent Depressive Disorder, Post Traumatic Stress Disorder, Pudendal Neuralgia, Reflex Sympathetic Dystrophy Syndrome, Somatoform Pain Disorder, Urinary Incontinence, Vulvodynia.

Side Effect

Possible side effects of Tryptizol include: increased need to urinate; cool, pale skin; Bigger, dilated, or enlarged pupils (black part of eye); difficulty in passing urine (dribbling); loss of sense of taste; swollen glands.

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Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These are not all the side effects of Tryptizol. For a full list see the leaflet inside your medicines packet.

You can report any suspected side effect to the UK safety scheme.

Mixing Tryptizol with herbal remedies and supplements

Do not take St John's wort, the herbal remedy for depression, while you are being treated with Tryptizol. It will increase your risk of side effects.

Warnings for people with certain health conditions

For people with heart disorders: Taking this drug could cause heart problems, such as irregular heart rhythm, heart attack, and stroke. Do not take this drug if you’re recovering from a recent heart attack.

For people with bipolar disorder: Before starting you on treatment with antidepressants such as Tryptizol, it’s important for your doctor to check your risk of bipolar disorder. Your doctor should do this because a major depressive episode is usually the first symptom noticed in people with bipolar disorder. This drug should not be used in people with bipolar disorder.

For people with a history of seizures: Taking this drug raises your risk of seizures. If you have a history of seizures, your doctor will monitor you closely while you’re taking this drug. If you have a seizure while taking this drug, stop taking it and call your doctor right away.

For people with a history of glaucoma or increased eye pressure: Taking this drug could increase the pressure in your eyes. If you have a history of glaucoma or increased eye pressure, your doctor will monitor you closely while you’re taking this drug.

Tryptizol side effects

Get emergency medical help if you have signs of an allergic reaction to Tryptizol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

unusual thoughts or behavior;

a light-headed feeling, like you might pass out;

chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

pounding heartbeats or fluttering in your chest;

a seizure (convulsions);

painful or difficult urination;

easy bruising, unusual bleeding; or

sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing.

Common Tryptizol side effects may include:

nausea, vomiting, upset stomach;

mouth pain, unusual taste, black tongue;

appetite or weight changes;

urinating less than usual;

itching or rash;

breast swelling (in men or women); or

decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Starting Tryptizol

One in four people will get significant pain relief with Tryptizol. This is regarded as an excellent result for chronic pain conditions. It is started at a low dose (10 or 25 mg a day) and gradually increased in 10 or 25 mg increments each week up towards 75 mg if side effects are tolerable. Your doctor may advise you to go higher than this dose. The tablets are small and difficult to cut in half, and will often produce numbness of the tongue due to a local anaesthetic effect, but it is available as a syrup. It is better to use the syrup if small increases of dose are required during the titration (dose build-up) phase.

Tryptizol 'High' and Abuse

There have been some anecdotal reports that consuming larger doses of Tryptizol can lead to a "high" or hallucinations in some people.

Trying to get a high off of Tryptizol or any prescription medication is extremely dangerous and could lead to severe side effects or a life-threatening overdose.

Because of its abuse potential, and the risk of serious side effects, keep this and all medications away from children, teenagers, and anyone for whom it was not prescribed.

Serious Side Effects of Tryptizol

Tell your doctor or go to an emergency room right away if you experience any of the following serious side effects:

  • Slow or difficult speech
  • Dizziness or faintness
  • Weakness or numbness of an arm or a leg
  • Crushing or heavy chest pain
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What is the dosage for Tryptizol?

Tryptizol may be taken with or without food. The recommended adult dose is 100-300 mg daily in divided doses or at bedtime. The initial dose is 50-100 mg at bedtime that may be increased by 25 or 50 mg at bedtime as needed. The lowest effective dose should be used.

Before taking Tryptizol,

  • tell your doctor and pharmacist if you are allergic to Tryptizol or any other medications.
  • tell your doctor if you are taking cisapride (Propulsid) (not available in the U.S.) or monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have taken an MAO inhibitor during the past 14 days. Your doctor will probably tell you that you should not take Tryptizol.
  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antihistamines; cimetidine (Tagamet); diet pills; disulfiram (Antabuse); guanethidine (Ismelin); ipratropium (Atrovent); quinidine (Quinidex); medications for irregular heartbeats such as flecainide (Tambocor) and propafenone (Rythmol); medications for anxiety, asthma, colds, irritable bowel disease, mental illness, nausea, Parkinson's disease, seizures, ulcers, or urinary problems; other antidepressants; phenobarbital (Bellatal, Solfoton); sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; thyroid medications; and tranquilizers. Tell your doctor or pharmacist if you have stopped taking fluoxetine (Prozac, Sarafem) in the past 5 weeks.Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have recently had a heart attack. Your doctor will probably tell you not to take Tryptizol.
  • tell your doctor if you drink large amounts of alcohol and if you have or have ever had glaucoma (an eye condition); an enlarged prostate (a male reproductive gland); difficulty urinating; seizures; an overactive thyroid gland (hyperthyroidism); diabetes; schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions); or liver, kidney, or heart disease.
  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking Tryptizol, call your doctor. Do not breast-feed while you are taking Tryptizol.
  • talk to your doctor about the risks and benefits of taking this medication if you are 65 years of age or older. Older adults should not usually take Tryptizol because it is not as safe or effective as other medication(s) that can be used to treat the same condition.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Tryptizol.
  • you should know that Tryptizol may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • remember that alcohol can add to the drowsiness caused by this medication.

Rated Tryptizol (Elavil) for Neuropathic Pain Report

This drug turned my life around. I was in constant pain, had zero appetite and could not sleep because of my nerve pain. My doctor put me on 30 mg and folic acid and I can finally function normal again!

Tryptizol Dosage

Tryptizol comes in a tablet form.

The recommended dose is 100-300 milligrams (mg) for most adults, and 25 mg for elderly patients. The initial dose is typically between 50-100 mg.

This medicine can be taken with or without food.

How should I take Tryptizol?

Take Tryptizol exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

If you need surgery, tell the surgeon ahead of time that you are using Tryptizol. You may need to stop using the medicine for a short time.

Do not stop using Tryptizol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Tryptizol.

Store at room temperature away from moisture, heat, and light.

Neuropathic Pain

Tryptizol applied to rodent paws made neuropathic by a chronic nerve constriction injury produced an antinociceptive effect. When Tryptizol was applied to the contralateral paw, no antinociceptive effect was observed in the paw on the injured side. When desipramine and the selective serotonin reuptake inhibitor fluoxetine were studied, desipramine had a similar antinociceptive effect when applied topically, whereas fluoxetine did not.

Warnings for other groups

For pregnant women: Tryptizol is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

For women who are breastfeeding: Tryptizol passes into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. These side effects include fast heart rate, difficulty urinating, constipation, dry mouth, and blurred vision.

For children: It has not been confirmed that this drug is safe and effective for use in children younger than 18 years. Use of this drug in children must balance the potential risks with the clinical need.

Human Pain

Human ev >Tryptizol application failed to produce any pain relief, but the maximum therapy duration was 7 days; therefore, the study may have been terminated before the time to maximal effect had been reached.

Case studies have provided results of a useful reduction in pain when 5% doxepin cream was applied topically in subjects with complex regional pain syndrome type I and when doxepin was used as an oral rinse in patients with oral pain as a result of cancer or cancer therapy.

Whereas the human evidence of an analgesic effect with topical doxepin is interesting, more study is needed to verify this and other TCA effects for this route of administration. The evidence suggests that the effect of topically applied doxepin is local and that the consequences of systemic administration and, hence, systemic side effects can be substantially reduced. Doxepin in a 5% cream formulation is currently available as Zonalon, which is indicated for the treatment of itch associated with eczema.


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