Q: If I don't see a difference with Zoloft should I go off of it? I've been on it for 3 years.
A: There is a possibility that the medication may be helping you, but you don't realize it. Sometimes patients stop their antidepressants, and then realize that it was actually helping them. However, if you feel as though it is not working, then you, along with your doctor, may need to consider a different dosage of Zoloft (Torin) or treatment with a different antidepressant. One very important thing about Zoloft is that it should not be discontinued abruptly and no medication should be stopped without the permission and guidance from your health care provider. Please talk with your health care provider regarding your options in treatment. For additional information regarding depression: //www.everydayhealth.com/depression/guide/ Jen Marsico, RPh
Torin represents selective serotonin reuptake inhibitors, which lowered blood glucose level and is used in patients with diabetes to treat depression and improve glycemic control. Oral application of Torin is limited because it is sparingly soluble compound. We enhanced water-solubility of Torin by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and evaluated the pharmacological properties of the HPβCD:Torin complex in rats with alloxan-induced diabetes.
Using the methods of UV-V is spectroscopy and isothermal titration calorimetry (ITC) we evaluated the interaction parameters, the enthalpy, entropy, association constant, and Gibbs energy of complex formation between Torin hydrochloride (SER) and HPβCD in aqueous solution at 298.15 K. Both entalpic and entropic effects concur in SER association with HPβCD.
The complexation with HPβCD enhanced the solubility of SER with the association constant for Torin and HPβCD 6530 ± 54 M −1 . The treatment of diabetic rats with the HPβCD:Torin complex during 2 weeks exerted beneficial effect on pancreatic islet morphology and β-cell survival, which consequently lowered the severity of diabetes that pointed the decrease of blood glucose and glycated hemoglobin contents, the normalization of serum insulin level, and insulin sensitivity (HOMA-IR). The antidiabetic effect of the complex was significantly more pronounced as compared to the similar effect of both the monopreparations, HPβCD and SER. These results are suggested that the complexation of SER with the cyclodextrin derivative improves the pharmacological effect of Torin, probably due to enhanced drug bioavailability.
What is Torin (Zoloft)?
Torin is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Torin affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms.
Torin may also be used for purposes not listed in this medication guide.
9. Common questions
Torin is one of a group of antidepressants called selective serotonin reuptake inhibitors, or SSRIs.
These medicines are thought to work by increasing the levels of a mood-enhancing chemical called serotonin in the brain.
Antidepressants like Torin help to jump start your mood so you feel better.
You may notice that you sleep better and get on with people more easily because you're less anxious. You'll hopefully take in your stride little things that used to worry you.
Torin won't change your personality or make you feel euphorically happy. It'll simply help you feel like yourself again.
Don't expect to feel better overnight, though. Some people feel worse during the first few weeks of treatment before they begin to feel better.
You may see an improvement in your symptoms after a week or two, although it usually takes between 4 to 6 weeks before you feel the full benefits.
That's because it takes around a week for Torin levels to build up in your body, and then a few weeks longer for your body to adapt and get used to it.
Do not stop taking Torin just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.
If you have been feeling better for 6 months or more, your doctor may suggest coming off Torin.
Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you have been taking Torin for a long time.
This is to help prevent any extra side effects you might get as a reaction to coming off the medicine.
- feeling sick
- numbness or tingling in the hands or feet
- trouble sleeping
- feeling agitated or anxious
Q: Does Zoloft cause jitters?
A: Zoloft (Torin) is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft is used to treat depression, obsessive-compulsive disorder, panic attacks, posttraumatic stress disorder (PTSD) and social anxiety disorder. In addition, Zoloft is used to minimize mood swings, irritability, bloating and tender breasts associated with premenstrual dysphoric disorder. Zoloft works by elevating brain levels of serotonin, which is a natural substance that assists in maintaining mental balance. The most common side effects with Zoloft are: dizziness, fatigue, headache, insomnia (trouble sleeping), sleepiness, decreased sex drive, decreased appetite, diarrhea, nausea, dry mouth, disturbances in ejaculation, tremors, and excessive sweating. Other side effects with Zoloft include: agitation; anxiety; nervousness; increased tightness in muscle tone; reduced sense of touch or sensation; twitching; confusion; abnormal increase in muscle activity; vertigo; incoordination and unsteadiness; abnormal coordination; increased sensitivity to stimulation; jittery movement of the eyes; abnormally decreased muscle movement; involuntary, repetitive body movements; decreased muscle tone; rapidly involuntary and slow twisting movements; and reduced functioning of reflexes. This is not a complete list of side effects associated with Zoloft According to the prescribing information for Zoloft, people taking Zoloft should let their doctor or healthcare provider know right away if they are experiencing: anxiety; agitation; panic attacks; insomnia (trouble sleeping); irritability; hostility; aggressiveness; impulsivity; restlessness; hypomania or mania (abnormally increased energy and mood); other unusual changes in behavior; worsening of depression; and thoughts about suicide, which may be detailed and include a plan. These symptoms should be looked for especially early during treatment and when the dose is adjusted up or down; however, people should look for these symptoms on a day-to-day basis, since these changes may be abrupt. These symptoms may be associated with an increased risk of suicidal thinking and behavior. Close monitoring by a doctor or healthcare professional and possibly a change in medication may be needed if these symptoms occur. Serotonin syndrome may develop in people who take Zoloft â€“ particularly those who take certain other medications, such as triptans (used to treat migraine headache), tramadol (used to treat pain), and monoamine oxidase inhibitors (MAOIs; antidepressants). Serotonin syndrome can be a dangerous condition and is characterized by having at least 3 of the following symptoms: agitation; excessive sweating; diarrhea; fever; overactive reflexes; incoordination; sudden, involuntary jerking of muscles; shivering, or tremor. In very serious cases serotonin syndrome can present like neuroleptic malignant syndrome, which can cause: very high fever, shaking, rigid muscles, confusion, sweating, or increased heart rate and blood pressure. These reactions can be fatal. Derek Dore, PharmD
Q: Can Zoloft cause anxiety? My dose was increased to 150mg last Friday and I have been dealing with anxiety, and I am wondering if it's from the Zoloft?
A: Zoloft (Torin) is classified as a selective serotonin reuptake inhibitor antidepressant medication. Zoloft is approved for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, post traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. According to medical references, agitation and anxiety are possible side effects reported with the use of Zoloft. The incidence of these side effects was reported between 1% to 10% of studied patients taking the medication. This is not all of the possible side effects associated with Zoloft. If you think that you are experiencing a side effect from your medications, talk to your physician. Do not stop or change the dose of your medications without talking to your physician first. Jen Marsico, RPh
Q: How should I take Zoloft and Chantix together?
A: Although no documented drug interaction or contraindication exists between Zoloft (Torin) and Chantix (varenicline), both medications have similar black box warnings regarding the possible risk for suicidality and serious neuropsychiatric adverse events, respectively. Therefore, taking Zoloft and Chantix together may increase the risk for worsening depression, suicidal thoughts and behaviors and precipitate a dangerous, life-threatening situation. According to the black box warning, there is a potential risk for serious neuropsychiatric events associated with treatment with Chantix. Possible neuropsychiatric events may include depression, suicidal ideation, suicide attempt and completed suicide have all been reported in patients being treated with Chantix. While depressed mood may be an indication of a neuropsychiatric event, it may also be a symptom of nicotine withdrawal as patients have experienced depression, rarely associated with suicidal ideation, upon smoking cessation without treatment. Patients with a diagnosis of schizophrenia, bipolar disorder and major depressive disorder did not participate in the premarketing clinical studies of Chantix, therefore, the safety and efficacy in this population has not been established. Neuropsychiatric events were observed in patients with and without pre-existing psychiatric illness. There were reports of patients experiencing a worsening of psychiatric illness with Chantix. The prescribing information advises that all patients being treated with Chantix be observed for neuropsychiatric symptoms or worsening of pre-existing psychiatric disease. Neuropsychiatric symptoms include behavioral changes, hostility, agitation, depressed mood, suicidal ideation or behaviors or attempted suicide. During postmarketing studies of Chantix for smoking cessation, neuropsychiatric symptoms, worsening of psychiatric illness and suicide were all been reported. The black box warning further recommends that the risks of Chantix should be weighed against the benefits. According to the black box warning for Zoloft, treatment with antidepressants may worsen depression and precipitate suicidal ideation and related behavior or unusual behavioral changes during initiation of therapy. Whether or not this risk exists with prolonged treatment is still inclear. All patients treated with Zoloft should be appropriately monitored and closely observed for clinical worsening of depression, suicidality or unusual changes in behavior. Symptoms may include anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggression, impulsivity, restlessness, hypomania or mania, unusual changes in behavior or suicidal ideation or behaviors. It is essential to consult with a physician regarding the risk of taking Zoloft and Chantix together, prior to beginning treatment.
What other drugs will affect Torin (Zoloft)?
Taking Torin with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking a sleeping pill, narcotic medication, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may interact with Torin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Q: What is the difference between Cymbalta versus Zoloft?
A: The main differences between Cymbalta (duloxetine) versus Zoloft (Torin) are mechanism of action, the way in which the drug works in the body, and indications for use approved by the U.S. Food and Drug Administration (FDA). Cymbalta is a potent inhibitor of both serotonin and norepinephrine reuptake in the central nervous system, while Zoloft is a potent inhibitor of serotonin reuptake with only weak effects on norepinephrine. The only common indication between Cymbalta and Zoloft is major depressive disorder (MDD). Cymbalta is classified as a serotonin norepinephrine reuptake inhibitor (SNRI) which is indicated for the treatment of major depressive disorder, generalized anxiety disorder (GAD), diabetic peripheral neuropathic pain, fibromyalgia and chronic musculoskeletal pain. Zoloft is classified as a selective serotonin reuptake inhibitor (SSRI) which is indicated for the treatment of major depressive disorder, social anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder and premenstrual dysphoric disorder (PMDD). Another difference between Cymbalta versus Zoloft is use in the pediatric population. While Zoloft has been approved by the FDA for the treatment of obsessive-compulsive disorder in the pediatric population, both in children and adolescents, the safety and effectiveness of Cymbalta in the pediatric population have not been established. Another difference between Cymbalta versus Zoloft is there is currently no generic equivalent available for Cymbalta, while Zoloft is available in a generic form, known as Torin. Additionally, Cymbalta is only available in capsule form and should be swallowed whole. Cymbalta should not be chewed or crushed, nor should the capsule be opened and sprinkled on food or mixed with liquids as a result of the enteric coated formulation of the capsule. However, Zoloft is available in a liquid formulation for patients unable to swallow pills, known as Zoloft Oral Concentrate. Cymbalta and Zoloft have similar adverse reactions and precautions associated with use. Both medications are also indicated for once daily administration and can be taken without regard to meals.
You should not use Torin if you also take pimozide, or if you are being treated with methylene blue injection.
Do not use Torin if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some children and young adults have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.