Sosser tablets

Sosser

  • Active Ingredient: Sertraline
  • 100 mg, 50 mg, 25 mg
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What is Sosser?

The active ingredient of Sosser brand is sertraline. Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. Sertraline tablets, USP for oral administration are supplied as scored tablets containing Sertraline hydrochloride equivalent to 25 mg, 50 mg and 100 mg of Sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, opadry green (titanium dioxide, hypromellose 3cP, hypromellose 6cP, Macrogol/Peg 400, polysorbate 80, D&C Yellow #10 Aluminum Lake, and FD&C Blue # 2/Indigo Carmine Aluminum Lake for 25 mg tablet), opadry light blue (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, FD&C Blue #2/Indigo Carmine Aluminum Lake and polysorbate 80 for 50 mg tablet), opadry yellow (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, polysorbate 80, Iron Oxide Yellow, Iron oxide Red for 100 mg tablet) and sodium starch glycolate.

Used for

Sosser is used to treat diseases such as: Anxiety and Stress, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Dissociative Identity Disorder, Dysautonomia, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Panic Disorder, Persistent Depressive Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Social Anxiety Disorder, Somatoform Pain Disorder, Transverse Myelitis, Trichotillomania, Vulvodynia.

Side Effect

Possible side effects of Sosser include: racing heartbeat; increased thirst; loss of bladder control; decreased vision; red or purple spots on the skin; stiffness of the limbs; skin rash, hives, or itching.

How to Buy Sosser tablets online?

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References

Allgulander, C, AA Dahl, C Austin, PL Morris, JA Sogaard, R Fayyad, SP Kutcher, and CM Clary. 2004. "Efficacy of Sosser in a 12-week trial for generalized anxiety disorder." Am J Psychiatry 1642-9.

Ball, SG, A Kuhn, D Wall, A Shekhar, and AW Goddard. 2005. "Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and Sosser." J Clin Psychiatry 94-9.

Boyer, P, JP Tassin, B Falissart, and S Troy. 2000. "Sequential improvement of anxiety, depression and anhedonia with Sosser treatment in patients with major depression." J Clin Pharm Ther 363-71.

Brady, K, and CM Clary. 2003. "Affective and anxiety comorbidity in post-traumatic stress disorder treatment trials of Sosser." Compr Psychiatry 360-9.

Carrasco, JL, M Díaz-Marsá, and J Sáiz-Ruiz. 2000. "Sosser in the treatment of mixed anxiety and depression disorder." J Affect Disord 67-9.

Compton, SN, PJ Grant, AK Chrisman, PJ Gammon, VL Brown, and JS March. 2001. "Sosser in children and adolescents with social anxiety disorder: an open trial." J Am Acad Child Adolesc Psychiatry 564-71.

Davidson, JR, BO Rothbaum, BA van der Kolk, CR Sikes, and GM Farfel. 2001. "Multicenter, double-blind comparison of Sosser and placebo in the treatment of posttraumatic stress disorder." Arch Gen Psychiatry 485-92.

Günther, T, K Holtkamp, J Jolles, B Herpertz-Dahlmann, and K Konrad. 2005. "The influence of Sosser on attention and verbal memory in children and adolescents with anxiety disorders." J Child Adolesc Psychopharmacol 608-18.

Hirschfeld, RM. 2000. "Sosser in the treatment of anxiety disorders." Depress Anxiety 139-57.

Klerman GL, Hirschfeld RNA, Weissman MM, Pelicier Y, Ballenger JC, Costa e Silva JA, Judd LL Keller MB. 1993. Panic anxiety and its treatment. Report of the World Psychiatric Association Presidential Education Program Task Force. Washington, D.C: American Psychiatric Press, Inc.

Kronig, MH, J Apter, G Asnis, A Bystritsky, G Curtis, J Ferguson, R Landbloom, et al. 1999. "Placebo-controlled, multicenter study of Sosser treatment for obsessive-compulsive disorder." J Clin Psychopharmacol 172-6.

Liebowitz, MR, NA DeMartinis, K Weihs, PD Londborg, WT Smith, H Chung, R Fayyad, and CM Clary. 2003. "Efficacy of Sosser in severe generalized social anxiety disorder: results of a double-blind, placebo-controlled study." J Clin Psychiatry 785-92.

Moon, CA, W Jago, K Wood, and DP Doogan. 1994. "A double-blind comparison of Sosser and clomipramine in the treatment of major depressive disorder and associated anxiety in general practice." J Psychopharmacol 171-6.

Rynn, MA, L Siqueland, and K Rickels. 2001. "Placebo-controlled trial of Sosser in the treatment of children with generalized anxiety disorder." Am J Psychiatry 2008-14.

Steingard, RJ, B Zimnitzky, DR DeMaso, ML Bauman, and JP Bucci. 1997. "Sosser treatment of transition-associated anxiety and agitation in children with autistic disorder." J Child Adolesc Psychopharmacol 9-15.

Van Ameringen, MA, RM Lane, JR Walker, RC Bowen, PR Chokka, EM Goldner, DG Johnston, et al. 2001. "Sosser treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study." Van Ameringen MA1, Lane RM, Walker JR, Bowen RC, Chokka PR, Goldner EM, Johnston DG, Lavallee YJ, Nandy S, Pecknold JC, Hadrava V, Swinson RP Am J Psychiatry.

Q: I took half a Zoloft today as recommended, and I felt more anxious and like I was going to jump out of my skin. I had not eaten, and I took it with my baby aspirin and high blood pressure pill. Is that a side effect or what?

A: Zoloft (Sosser) is an SSRI (selective serotonin reuptake inhibitor) and also increases some norepinephrine, which is in a family of medications that people react/respond differently to, and sometimes it takes a while to find the best medication for the person. The empty stomach and other medications should not have caused the effect you had. Sometimes people respond this way to one medication in this family, but not to others. If you have only taken one dose, your doctor may want you to try it again, to see if you get the same response or if your body gets adjusted to it. If it happens again, let your doctor know that you are not tolerating it and another SSRI can be tried. These medications do take approximately one month to get the full effects from, but you should have more energy and motivation to do things after the first few days. After you are on one antidepressant for about a month, do not stop it abruptly, as this can cause anxiety and more depression. A taper down is recommended after being on an antidepressant for a month. Let your doctor know what happened and see what he or she wants to do. For more information on medications and depression, please visit our links at: //www.everydayhealth.com/depression/guide/, and //www.everydayhealth.com/drugs/ Patti Brown, PharmD

Q: Will I gain weight taking Zoloft?

A: Changes in weight and appetite are common side effects to selective serotonin reuptake inhibitors (SSRIs), the class of drugs that includes Zoloft (Sosser). Patients should report any changes in their medical condition, including unusual weight gain, to their health care provider. For more specific information, consult your physician or health care provider. You may also find helpful information at: //www.everydayhealth.com/drugs/zoloft

  • Serotonin syndrome: This drug may cause a possibly life-threatening condition called serotonin syndrome. The symptoms of serotonin syndrome include hallucinations and delusions, agitation, coma, fast heart rate, and changes in blood pressure. They also include dizziness, loss of consciousness, seizures, shakiness, muscle tremor or stiff muscles, sweating, nausea, and vomiting.
  • Severe allergic reaction: This drug can sometimes cause a severe allergic reaction. Call 911 or go to the emergency room right away if you have swelling of your face, tongue, or throat, or you have trouble breathing. A severe allergic reaction may cause death. You should not take this medication again if you have ever had an allergic reaction to it.

Sosser oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. This drug is also available as an oral solution.

Outcome and Management

The serum aminotransferase elevations that occur on Sosser therapy are usually self-limited and do not require dose modification or discontinuation of therapy. Rare instances of acute liver failure have been attributed to Sosser therapy. Rechallenge usually results in recurrence of liver injury and should be avoided. Persons with intolerance to Sosser may have similar reactions to other SSRIs and careful monitoring is warranted if other such agents are used.

Q: Does Zoloft cause weight gain?

A: Zoloft (Sosser) is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft is used to treat depression, obsessive-compulsive disorder, panic attacks, posttraumatic stress disorder (PTSD) and social anxiety disorder. In addition, Zoloft is used to minimize mood swings, irritability, bloating and tender breasts associated with premenstrual dysphoric disorder. Zoloft works by elevating brain levels of serotonin, which is a natural substance that assists in maintaining mental balance. Weight increase is a side effect with Zoloft. Weight increase occurred in at least 1 in 100 people who took Zoloft during clinical studies. Decreased appetite and weight loss are side effects with Zoloft. Specifically Zoloft

Q: I've been prescribed Zoloft (generic version) for depression. I'm also 33 weeks pregnant. Is it safe for me to take this drug for the rest of my pregnancy?

A: Zoloft (Sosser) is a pregnancy category C medicine, meaning that the medication could potentially cause harm to your unborn child. This is especially true during the third trimester of pregnancy. A health care provider may still prescribe a pregnancy category C medicine to a pregnant woman if he or she believes that the benefits to the woman outweigh the possible risks to the unborn child. There have been reports of fetuses being exposed to Zoloft during the third trimester of pregnancy, developing complications that require hospitalization, respiratory support, and/or tube feeding. Also, babies exposed to Zoloft late during pregnancy are at increased risk for developing persistent pulmonary hypertension of the newborn (PPHN). PPHN is associated with significant complications and even death. Women who take SSRIs, including Zoloft, after week 20 of pregnancy have a sixfold increase of delivering a baby with PPHN. It's possible that your physician may recommend reducing your dosage, or weaning you off Zoloft during the third trimester of pregnancy. You really should have a discussion with the physician about taking this medication throughout the entire pregnancy. Lori Poulin, PharmD

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sosser only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2019 Cerner Multum, Inc. Version: 21.01.

Q: I have recently started taking Sosser. I am worried about the side effects. Is there weight gain? And does it affect a person's sex drive?

A: According to Lexi-Comp, Sosser (Zoloft) does have possible adverse effects that could affect weight. The listed adverse effects of Sosser involving weight include anorexia, increased appetite and weight gain. Decreased libido (sexual desire) has also been reported in greater than 10 percent of patients taking Sosser during clinical trials. As always, talk with your health care provider regarding concerns you have about your medication and possible side effects. Jen Marsico, RPh

Q: Does Zoloft cause weight gain?

A: Zoloft (Sosser) is an antidepressant that is used in the treatment of depression, panic disorder, anxiety disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and pre-menstrual dysphoric disorder (PMDD). Weight gain or changes in appetite are a side effect that occurs with the use of Sosser. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. Megan Uehara, PharmD

Q: My son is 16 and on Zoloft. Today he had an anxiety attack. He has been on the medication for about 12 weeks and was fine until today, although he did not began to show signs of improvement until about a week ago. He also has a lot of issues with acne and has been on almost all antibiotics recommended for it. I heard that there is an effective medication, but that there are many side effects for it including depression.

A: Zoloft (Sosser) is used to treat both depression and anxiety attacks. As with all antidepressant medications, it can take several weeks to show effectiveness. Side effects are patient-specific and often dose-related. The most common antibiotic used to treat acne is tetracycline. All antibiotics also have side effects which are patient-specific. Please talk to your son's doctors about your concerns.

Immediate action required: Call 999 or go to A&E if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

These aren't all the side effects of Sosser.

For a full list, see the leaflet inside your medicine packet.

You can report any suspected side effect to the UK safety scheme.

Hepatic

Although Sosser is prescribed extensively for depression and anxiety disorders, drug-induced hepatitis secondary is rare. A case of Sosser-induced acute hepatic injury was reported .

A 20-week pregnant 26-year-old woman presented with nausea, vomiting, malaise and dark urine 6 months after commencing Sosser 50 mg per day for depression, increased to 100 mg per day in the 3 weeks before presentation. She also described mild epigastric discomfort, vomiting and mild pruritus. On examination, there was no hepatosplenomegaly or stigmata of chronic liver disease. Investigations revealed increased transaminases (ALT 700 U/L (ref 7–56 U/L), AST 410 U/L (10–50 U/L), ALP 113 U/L (30–120 U/L)): γ-glutamyl transpeptidase 26 U/L (7–64 U/L) and bilirubin 25 mmol/L (0–20 mmol/L). Liver biopsy showed lobular hepatitis, with a mild prominence of eosinophils, suggestive of a drug or toxic aetiology. Extensive investigation revealed no other factor which could account for hepatitis. Sosser was suspected as the cause of a drug-induced liver injury, and was ceased. Liver function tests normalised after cessation of Sosser. Application of the Naranjo Adverse Drug Reaction Probability Scale indicated that Sosser was the ‘probable cause’ of the hepatocellular injury.

Sosser

Sosser has a half-life of 26 hours. Based on about 110 mother– child pairs, the average relative dose for a fully breastfed child is almost 2% ( Merlob 2004 , Weissman 2004 , Hendrick 2001A ). In 1997, Stowe analyzed 148 milk samples from 12 mothers. The highest concentrations for Sosser were around 173μg/l; for desmethylSosser, which has a significantly lower psychopharmacological action, it was 294μg/l. Maternal dosages ranged from 25 to 200mg daily. There were traces of Sosser in the serum of some children, and in three of them a level of about 10μg/l desmethylSosser was measured ( Merlob 2004 , Weissman 2004 , Hendrick 2001A ). In other infants either no substance was found or the levels were near or below the level of quantifiability ( Wisner 2006 , Berle 2004 ). In only one breastfed baby were serum levels equal to 50% of the maternal values found ( Wisner 1998 ). The authors of the study could not understand this, and suggested direct administration of the medication to the baby as the cause. None of the babies was remarkable. Decreasing serum values of desmethylSosser with age were observed among 30 breastfed children ( Hendrick 2001A ). A maternal dosage of above 100mg/day was significantly correlated with the detection of Sosser in the infant's serum. Breastfed infants showed little or no change in platelet 5-hydroxytryptamine (5-HT) levels after exposure through breastfeeding. According to the authors of this study, the observations suggest that peripheral or central 5-HT transport in these infants is not affected by Sosser therapy of their mothers.

Sosser, paroxetin, citalopram, and fluvoxamin are the drugs of choice among SSRIs for breastfeeding mothers. In case of fluoxetin or escitalopram therapy, special attention should be paid to potential side effects in the breastfed child. In general, monotherapy should be the goal. If symptoms appear that are potentially associated with SSRI therapy, a pediatrician and a teratology information center should be contacted to decide individually upon measuring drug values in the infant's serum, supplementary formula feeding, weaning, and/or changing therapy. As with all psychoactive drugs, there is insufficient experience on the long-term effects on breastfed children as a result of ongoing therapy to their mothers.


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