Sertralix tablets


  • Active Ingredient: Sertraline
  • 100 mg, 50 mg, 25 mg
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What is Sertralix?

The active ingredient of Sertralix brand is sertraline. Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. Sertraline tablets, USP for oral administration are supplied as scored tablets containing Sertraline hydrochloride equivalent to 25 mg, 50 mg and 100 mg of Sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, opadry green (titanium dioxide, hypromellose 3cP, hypromellose 6cP, Macrogol/Peg 400, polysorbate 80, D&C Yellow #10 Aluminum Lake, and FD&C Blue # 2/Indigo Carmine Aluminum Lake for 25 mg tablet), opadry light blue (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, FD&C Blue #2/Indigo Carmine Aluminum Lake and polysorbate 80 for 50 mg tablet), opadry yellow (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, polysorbate 80, Iron Oxide Yellow, Iron oxide Red for 100 mg tablet) and sodium starch glycolate.

Used for

Sertralix is used to treat diseases such as: Anxiety and Stress, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Dissociative Identity Disorder, Dysautonomia, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Panic Disorder, Persistent Depressive Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Social Anxiety Disorder, Somatoform Pain Disorder, Transverse Myelitis, Trichotillomania, Vulvodynia.

Side Effect

Possible side effects of Sertralix include: increased clotting times; unexplained bleeding or bruising; severe sunburn; unpleasant breath odor; hostility; general feeling of discomfort, illness, tiredness, or weakness; drooling; diarrhea.

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Before taking Sertralix, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as latex found in the medicine dropper), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, bleeding problems, liver disease, seizure disorder, thyroid disease, personal or family history of glaucoma (angle-closure type).

Sertralix may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Sertralix, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Sertralix safely.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

The liquid form of this medication contains alcohol. Caution is advised if you have diabetes, alcohol dependence, or liver disease. Some medications (such as metronidazole, disulfiram) can cause a serious reaction when combined with alcohol. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially bleeding, loss of coordination, or QT prolongation (see above). Loss of coordination can increase the risk of falling. Older adults may also be more likely to develop a type of salt imbalance (hyponatremia), especially if they are taking "water pills" (diuretics).

Children may be more sensitive to the side effects of the drug, especially loss of appetite and weight loss. Monitor weight and height in children who are taking this drug.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Also, babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop withdrawal symptoms such as feeding/breathing difficulties, seizures, muscle stiffness, or constant crying. If you notice any of these symptoms in your newborn, tell the doctor promptly.

Since untreated mental/mood problems (such as depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, discuss with your doctor right away the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk. Consult your doctor before breast-feeding.


Hepatotoxicity has again been attributed to Sertralix (SEDA-30, 16) . In this case report, it presented within 6 months of treatment in a 17-year-old boy with no other demonstrable explanation.

8. Cautions with other medicines

Some medicines and Sertralix can interfere with each other and increase the chances of you having side effects.

  • any medicines that affect your heartbeat - Sertralix can speed up or change your heartbeat
  • any other medicines for depression - some antidepressants can interfere with Sertralix to cause very high blood pressure even when they have been stopped

Q: Is there a Zoloft liquid?

A: There is currently a Zoloft (Sertralix) liquid formulation available. Zoloft liquid, or Zoloft Oral Concentrate, contains the active ingredient Sertralix 20 mg/ml and 12% alcohol. The Zoloft liquid formulation is a clear, colorless solution with a menthol scent. It is available in two ounce bottles with an accompanying dropper to ensure accurate dose measurement. Bottles of Zoloft Oral Concentrate should be stored at controlled room temperature away from moisture and heat. Zoloft liquid must be diluted prior to administration. Prior to the administration of a dose, patients are instructed to use the calibrated dropper provided with the medication to remove the prescribed dose and mix with four ounces (1/2 cup) of water, ginger ale, lemon/lime soda, lemonade or orange juice. Do not mix the Zoloft Oral Concentrate with any other liquids than those recommended. Patients should be instructed to administer the dose immediately after mixing and caution not to mix in advance. Often times a slight haze appears after mixing and is normal. According to the prescribing information, patients with a latex sensitivity should exercise caution as the dropper dispenser contains dry natural rubber. Zoloft Oral Concentrate is contraindicated with Antabuse (disulfiram) because of the alcohol content of the concentrate. Zoloft liquid is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class of medications which has been approved, by the U.S. Food and Drug Administration (FDA), for the treatment of major depressive disorder, panic disorders, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Similar to Zoloft tablets, Zoloft liquid may take four weeks or longer to achieve full therapeutic activity and before patients begin to feel better. Patients are advised not to discontinue treatment with Zoloft liquid without first consulting with a physician to avoid unpleasant withdrawal effects including agitation, irritability, dizziness, sensory disturbances, headache, confusion, insomnia, dysphoric mood, lethargy and anxiety.

Short-term Effects

In short-term studies, antidepressant medicines increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (younger than 24 years) taking antidepressants for major depressive disorders and other psychiatric diseases.

See “What Are Side Effects Associated with Using Sertralix?”

Q: Can Zoloft cause anxiety? My dose was increased to 150mg last Friday and I have been dealing with anxiety, and I am wondering if it's from the Zoloft?

A: Zoloft (Sertralix) is classified as a selective serotonin reuptake inhibitor antidepressant medication. Zoloft is approved for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, post traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. According to medical references, agitation and anxiety are possible side effects reported with the use of Zoloft. The incidence of these side effects was reported between 1% to 10% of studied patients taking the medication. This is not all of the possible side effects associated with Zoloft. If you think that you are experiencing a side effect from your medications, talk to your physician. Do not stop or change the dose of your medications without talking to your physician first. Jen Marsico, RPh

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