2 Effects of Serlift on Alcohol Consumption
Serlift is another SSRI that has been clinically shown to reduce alcohol consumption. Studies have investigated the effects of Serlift in alcohol-dependent patients with and without lifetime histories of depression. The findings revealed that there was no antidepressive effect of Serlift; however, Serlift was effective in reducing alcohol intake in subjects without a lifetime history of depression. 275 It has also been revealed that Serlift treatment reduced alcohol intake in type A alcoholics but not in type B. 285 Further studies indicate that type A alcoholics demonstrated a consistent benefit from Serlift that lasted for at least 6 months after the completion of pharmacotherapy. 248 In contrast, Serlift has not been found to be efficacious in type B alcoholics during treatment or after. Serlift was actually shown to increase alcohol intake in type B alcoholics 6 months after withdrawal from the medication. It is suggested that there might be a deficit in 5-HT synthesis in the brains of type B alcoholics, 248 resulting in a neuroadaptative upregulation of some 5-HT receptors. Thus, treating type B alcoholics with SSRIs may induce neuronal overstimulation because of increased 5-HT at the synaptic cleft and resulting in increased alcohol intake. 93,286
Q: Can Zoloft cause anxiety? My dose was increased to 150mg last Friday and I have been dealing with anxiety, and I am wondering if it's from the Zoloft?
A: Zoloft (Serlift) is classified as a selective serotonin reuptake inhibitor antidepressant medication. Zoloft is approved for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, post traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. According to medical references, agitation and anxiety are possible side effects reported with the use of Zoloft. The incidence of these side effects was reported between 1% to 10% of studied patients taking the medication. This is not all of the possible side effects associated with Zoloft. If you think that you are experiencing a side effect from your medications, talk to your physician. Do not stop or change the dose of your medications without talking to your physician first. Jen Marsico, RPh
Q: How should I take Zoloft and Chantix together?
A: Although no documented drug interaction or contraindication exists between Zoloft (Serlift) and Chantix (varenicline), both medications have similar black box warnings regarding the possible risk for suicidality and serious neuropsychiatric adverse events, respectively. Therefore, taking Zoloft and Chantix together may increase the risk for worsening depression, suicidal thoughts and behaviors and precipitate a dangerous, life-threatening situation. According to the black box warning, there is a potential risk for serious neuropsychiatric events associated with treatment with Chantix. Possible neuropsychiatric events may include depression, suicidal ideation, suicide attempt and completed suicide have all been reported in patients being treated with Chantix. While depressed mood may be an indication of a neuropsychiatric event, it may also be a symptom of nicotine withdrawal as patients have experienced depression, rarely associated with suicidal ideation, upon smoking cessation without treatment. Patients with a diagnosis of schizophrenia, bipolar disorder and major depressive disorder did not participate in the premarketing clinical studies of Chantix, therefore, the safety and efficacy in this population has not been established. Neuropsychiatric events were observed in patients with and without pre-existing psychiatric illness. There were reports of patients experiencing a worsening of psychiatric illness with Chantix. The prescribing information advises that all patients being treated with Chantix be observed for neuropsychiatric symptoms or worsening of pre-existing psychiatric disease. Neuropsychiatric symptoms include behavioral changes, hostility, agitation, depressed mood, suicidal ideation or behaviors or attempted suicide. During postmarketing studies of Chantix for smoking cessation, neuropsychiatric symptoms, worsening of psychiatric illness and suicide were all been reported. The black box warning further recommends that the risks of Chantix should be weighed against the benefits. According to the black box warning for Zoloft, treatment with antidepressants may worsen depression and precipitate suicidal ideation and related behavior or unusual behavioral changes during initiation of therapy. Whether or not this risk exists with prolonged treatment is still inclear. All patients treated with Zoloft should be appropriately monitored and closely observed for clinical worsening of depression, suicidality or unusual changes in behavior. Symptoms may include anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggression, impulsivity, restlessness, hypomania or mania, unusual changes in behavior or suicidal ideation or behaviors. It is essential to consult with a physician regarding the risk of taking Zoloft and Chantix together, prior to beginning treatment.
Q: What exactly will drinking alcohol and taking Zoloft do?
A: Zoloft (Serlift) is an antidepressant classified as a selective serotonin reuptake inhibitor (SSRI). Zoloft (Serlift) works on chemicals in the brain to treat depression, obsessive-compulsive disorder (OCD), panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). It may also be used to treat other conditions as determined by your health care provider. Some of the most commonly reported side effects associated with Zoloft (Serlift) therapy include drowsiness, dizziness, feeling tired, nausea, upset stomach, constipation, dry mouth, changes in weight or appetite, difficulty sleeping and decreased sex drive or difficulty having an orgasm. This is not a complete list of possible side effects so it is important to consult your health care provider if you experience anything unusual or bothersome. According to the prescribing information, patients being treated with Zoloft (Serlift) should avoid alcohol. Although studies did not show an increase in mental or motor skill impairment with alcohol, patients taking Zoloft (Serlift) are still advised to avoid alcohol. Zoloft (Serlift) may be taken with our without food and should be taken with water. It is important to take your dose at the same time each day. Beth Isaac, PharmD
Q: Is there a Zoloft liquid?
A: There is currently a Zoloft (Serlift) liquid formulation available. Zoloft liquid, or Zoloft Oral Concentrate, contains the active ingredient Serlift 20 mg/ml and 12% alcohol. The Zoloft liquid formulation is a clear, colorless solution with a menthol scent. It is available in two ounce bottles with an accompanying dropper to ensure accurate dose measurement. Bottles of Zoloft Oral Concentrate should be stored at controlled room temperature away from moisture and heat. Zoloft liquid must be diluted prior to administration. Prior to the administration of a dose, patients are instructed to use the calibrated dropper provided with the medication to remove the prescribed dose and mix with four ounces (1/2 cup) of water, ginger ale, lemon/lime soda, lemonade or orange juice. Do not mix the Zoloft Oral Concentrate with any other liquids than those recommended. Patients should be instructed to administer the dose immediately after mixing and caution not to mix in advance. Often times a slight haze appears after mixing and is normal. According to the prescribing information, patients with a latex sensitivity should exercise caution as the dropper dispenser contains dry natural rubber. Zoloft Oral Concentrate is contraindicated with Antabuse (disulfiram) because of the alcohol content of the concentrate. Zoloft liquid is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) class of medications which has been approved, by the U.S. Food and Drug Administration (FDA), for the treatment of major depressive disorder, panic disorders, anxiety disorders, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) and premenstrual dysphoric disorder (PMDD). Similar to Zoloft tablets, Zoloft liquid may take four weeks or longer to achieve full therapeutic activity and before patients begin to feel better. Patients are advised not to discontinue treatment with Zoloft liquid without first consulting with a physician to avoid unpleasant withdrawal effects including agitation, irritability, dizziness, sensory disturbances, headache, confusion, insomnia, dysphoric mood, lethargy and anxiety.
What is Serlift?
Serlift is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Serlift affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms.
Serlift is used to treat depression, obsessive-compulsive disorder, anxiety disorders (including panic disorder and social anxiety disorder), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).
How much will I take?
The usual dose of Serlift is 50mg a day in adults. But it might be started at a lower dose, then increased gradually to a maximum dose of 200mg a day.
If you have liver problems, your doctor might give you a lower dose or advise you to take Serlift less often.
The usual dose of Serlift in children aged 6 to 12 is 25mg a day, but this may be increased to 50mg a day after a week.
The usual dose of Serlift in children aged 13 to 17 is 50mg a day. Children aged 6 to 17 might have their dose increased up to 200mg a day, if needed.
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as Serlift during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant.
You should know that your mental health may change in unexpected ways when you take Serlift or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; new or worsening anxiety; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
Your healthcare provider will want to see you often while you are taking Serlift, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Serlift. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.
No matter what your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.
Pregnancy and Lactation
Use Serlift with caution during pregnancy if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
Use of Serlift late in the third trimester is associated with complications in newborns and may require prolonged hospitalization, respiratory support, and tube feeding.
Persistent pulmonary hypertension of the newborn
- Potential risk of persistent pulmonary hypertension of the newborn (PPHN) when used during pregnancy
- Initial public health advisory in 2006 was based on a single published study; since then, there have been conflicting findings from new studies, making it unclear whether use of SSRIs during pregnancy can cause PPHN
- FDA has reviewed the additional new study results and has concluded that, given the conflicting results from different studies, it is premature to reach any conclusion about a possible link between SSRI use in pregnancy and PPHN
- FDA recommendation: FDA advises healthcare professionals not to alter their current clinical practice of treating depression during pregnancy and to report any adverse events to the FDA MedWatch program
- A meta-analysis of 7 observational studies, found exposure to SSRIs in late pregnancy (i.e., greater than 20 weeks' gestation) more than doubled the risk of PPHN that could not be explained by other etiologies (e.g., congenital malformations, meconiumaspiration) (BMJ 2014;348:f6932)
Serlift is distributed into breast milk; use caution when breastfeeding (American Academy of Pediatrics states effect on nursing infants is unknown but may be of concern).
Interactions that increase the risk of side effects
Taking certain medications with Serlift may result in increased side effects. These drugs include:
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, aspirin and warfarin. Taking these drugs with Serlift increases your risk of bleeding or bruising.
- Triptans such as sumatriptan. Your risk of serotonin syndrome is increased when you take these drugs with Serlift. Your doctor should watch you closely if you take these drugs together.
- Lithium. Taking this drug with lithium increases your risk of serotonin syndrome.
- Serotonergic medications such as fentanyl, tramadol, and St John’s wort. Taking these drugs with Serlift increases your risk of serotonin syndrome.
- Cimetidine. Taking cimetidine with Serlift may cause a build-up of Serlift in your body. Your dose of Serlift might need to be lowered if you take it with cimetidine.
- Tricyclic antidepressants such as amitriptyline, desipramine, and imipramine. Taking Serlift with these drugs may cause these drugs to build up in your body. Your doctor may need to adjust your dosage of tricyclic antidepressants while you take Serlift.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Serlift oral tablet comes with several warnings.
Serlift represents selective serotonin reuptake inhibitors, which lowered blood glucose level and is used in patients with diabetes to treat depression and improve glycemic control. Oral application of Serlift is limited because it is sparingly soluble compound. We enhanced water-solubility of Serlift by complexation with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and evaluated the pharmacological properties of the HPβCD:Serlift complex in rats with alloxan-induced diabetes.
Using the methods of UV-V is spectroscopy and isothermal titration calorimetry (ITC) we evaluated the interaction parameters, the enthalpy, entropy, association constant, and Gibbs energy of complex formation between Serlift hydrochloride (SER) and HPβCD in aqueous solution at 298.15 K. Both entalpic and entropic effects concur in SER association with HPβCD.
The complexation with HPβCD enhanced the solubility of SER with the association constant for Serlift and HPβCD 6530 ± 54 M −1 . The treatment of diabetic rats with the HPβCD:Serlift complex during 2 weeks exerted beneficial effect on pancreatic islet morphology and β-cell survival, which consequently lowered the severity of diabetes that pointed the decrease of blood glucose and glycated hemoglobin contents, the normalization of serum insulin level, and insulin sensitivity (HOMA-IR). The antidiabetic effect of the complex was significantly more pronounced as compared to the similar effect of both the monopreparations, HPβCD and SER. These results are suggested that the complexation of SER with the cyclodextrin derivative improves the pharmacological effect of Serlift, probably due to enhanced drug bioavailability.