Sensival capsules


  • Active Ingredient: Nortriptyline
  • 25 mg
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What is Sensival?

The active ingredient of Sensival brand is nortriptyline. Nortriptyline is a tricyclic antidepressant. Nortriptyline affects chemicals in the brain that may be unbalanced in people with depression. C19H21Nв€™HCl MW = 299.8 Each capsule, for oral administration, contains Nortriptyline hydrochloride equivalent to 10 mg, 25 mg, 50 mg, and 75 mg of Nortriptyline hydrochloride USP. In addition, each capsule contains the following inactive ingredients: black iron oxide, colloidal silicon dioxide, D&C Yellow #10 (aluminum lake), D&C Yellow #10, FD&C Blue #1 (aluminum lake), FD&C Blue #2 (aluminum lake), FD&C Green #3 (10, 50 and 75 mg only), FD&C Red #40 (aluminum lake), gelatin, I.M.S. 74 OP, magnesium stearate, pregelatinized corn starch, shellac, sodium lauryl sulfate and titanium dioxide.

Used for

Sensival is used to treat diseases such as: Burning Mouth Syndrome, Cyclic Vomiting Syndrome, Depression, Diabetic Peripheral Neuropathy, Dysautonomia, Irritable Bowel Syndrome, Migraine Prevention, Neuralgia, Neurosis, Pain, Panic Disorder, Postherpetic Neuralgia, Primary Nocturnal Enuresis, Reflex Sympathetic Dystrophy Syndrome, Smoking Cessation, Tinnitus, Vulvodynia.

Side Effect

Possible side effects of Sensival include: confusion about identity, place, and time false beliefs that cannot be changed by facts; stiffness of the limbs; increased sensitivity of the eyes or skin to light; feeling, seeing, or hearing things that are not there; weakness in the arms, hands, legs, or feet.

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Missed Dose of Sensival

If you miss a dose of Sensival, take it as soon as you remember.

However, if it is almost time for your next dose, skip the missed dose and continue on your regular schedule.

Do not "double up" to make up for a missed one.

What is Sensival?

Sensival is a tricyclic antidepressant. Sensival affects chemicals in the brain that may be unbalanced in people with depression.

Sensival is used to treat symptoms of depression.

Sensival may also be used for purposes not listed in this medication guide.

Rated Sensival (Pamelor) for Neuropathic Pain Report

I have nerve pain in my shoulder that runs down to my finger tips. Sensival makes it so I don’t feel that annoying pain. I have tried Gabapentin and that just made me loopy. Sensival Works for me.

How does Trazadone interact with Sensival. Can I safely take both?

Updated 2 Mar 2015 • 3 answers

Warnings for people with certain health conditions

For people with heart and other cardiovascular disorders: Taking this drug may increase your risk of stroke and heart problems, such as irregular heart rhythm or heart attack. Do not take this drug if you’re recovering from a recent heart attack.

For people with bipolar disorder: Before starting therapy with antidepressants, it’s important for your doctor to check your risk of bipolar disorder. If you have bipolar disorder that’s not being treated, taking Sensival can make your condition worse.

For people with a history of seizures: Taking this drug may increase your risk of seizures. If you have a history of seizures, your doctor will monitor you more closely. If you have a seizure while taking Sensival, stop taking it and call your doctor.

For people with glaucoma or increased eye pressure: Taking this drug could increase the pressure in your eyes. If you have a history of glaucoma or increased eye pressure, your doctor will monitor you more closely while you take Sensival.

For people with urinary retention: Taking this drug could make symptoms of urinary retention worse. If you have a history of urinary retention, your doctor will monitor you more closely while you take Sensival.

For people with hyperthyroidism or who take thyroid medication: Taking this drug could increase heart rhythm irregularity for you. Your doctor will need to monitor you very closely.

Rated Sensival (Pamelor) for Migraine Prophylaxis Report

I started taking Sensival about 23 years ago to prevent migraines. It has been very effective for me, as it reduced both the frequency and intensity of migraine. Daily dose 50 mg works well to prevent migraines. Initially it made me sleepy and caused a bit of a dry mouth but both of those went away after about 6 weeks. No other side effects.

How it works

Sensival belongs to a class of drugs called tricyclic antidepressants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Sensival works on your central nervous system to increase the level of certain chemicals in your brain. This helps relieve your depression.

Sensival oral capsule may cause drowsiness. It may also cause other side effects.

Rated Sensival (Pamelor) for Depression Report

I was given this drug in late 1981. I no longer remember the dose. Taking it was the worst mistake of my life. I will admit that the depression lifted within a week, but then bad things started happening: 1. Hyperpigmentation due to sun exposure. I lived in Florida,. The Sun was unavoidable. I was in my early twenties. My appearance mattered to me and I hated this. 2. The worst was rage. I was angry before, but in a rage within a week or two. The rage persisted even after I stopped taking the drug. Something was knocked out of balance in my brain and didn't go back to balance after I stopped taking the drug. I lost my temper all the time, flipped people off in traffic, dreamed about flogging people. This was a total change in personality. I used to be a mellow person. Now, I am a witch. 3. The drug interferes with oxytocin, which is involved in the menstrual cycle. I had very difficult emotional symptoms for the week before and the week during menstruation. I was in a rage. I was severely depressed. I mean really depressed and this depression continued for decades until I reached menopause. Decades after I stopped taking the drug. I had to go on a macrobiotic brown rice

Rated Sensival (Pamelor) for Migraine Prophylaxis Report

This medication is life changing. Has cut my migraine days per month in half! I’m a 24 y.o female taking 30 mg 1 x a day. Doc tried me at 50 and I experienced constipation, so brought me back down to 30 and I have been regular again. Helps with depression and MAJORLY helps my sleep problems, too. Now at 30 mg, I have almost zero side effects. Occasional dry mouth. I highly recommend.

Before taking this medicine

You should not use Sensival if you are allergic to it, or if:

you have recently had a heart attack;

you are allergic to similar antidepressants (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, protriptyline, trimipramine); or

you are allergic to certain seizure medications (carbamazepine, eslicarbazepine, oxcarbazepine, rufinamide).

Do not use Sensival if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine, as well as methylene blue injection.

To make sure Sensival is safe for you, tell your doctor if you have:

heart disease, or a history of heart attack, stroke, or seizures;

bipolar disorder (manic-depression);

schizophrenia or other mental illness;

a thyroid disorder;

diabetes (Sensival may raise or lower blood sugar);

narrow-angle glaucoma; or

problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Sensival. Your family or other caregivers should also be alert to changes in your mood or symptoms.

It is not known whether Sensival will affect an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether Sensival passes into breast milk or if it could affect a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give this medicine to a child without medical advice. Sensival is not approved for use in children.

Usual Adult Dose

25 mg three or four times daily; dosage should begin at a low level and be increased as required. As an alternative regimen, the total daily dosage may be given once a day. When doses above 100 mg daily are administered, plasma levels of Sensival should be monitored and maintained in the optimum range of 50 to 150 ng/mL. Doses above 150 mg/day are not recommended.


  • In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (under 24 years) taking antidepressants for major depressive disorders or other psychiatric illnesses
  • This increase was not seen in patients aged over age 24 years; a slight decrease in suicidal thinking was seen in adults over age 65 years
  • In children and young adults, risks must be weighed against the benefits of taking antidepressants
  • Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during the initial 1-2 months of therapy and dosage adjustments
  • The patient's family should communicate any abrupt changes in behavior to the healthcare provider
  • Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy
  • This drug is not approved for use in pediatric patients
  • This medication contains Sensival. Do not take Pamelor or Aventyl if you are allergic to Sensival or any ingredients contained in this drug
  • Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately

How long does Sensival take to work for chronic tension headaches?

Updated 6 Jan 2015 • 1 answer

Sensival 'High' and Abuse

There have been some anecdotal and online reports that taking large doses of Sensival can lead to a "high" or hallucinations in some people.

Trying to get a high from Sensival or any prescription medication is dangerous and could lead to severe side effects or a life-threatening overdose.

Take Sensival only as directed, and keep this and all other drugs away from children, teenagers, and anyone for whom the drug has not been prescribed.

Why it’s used

Sensival is used to treat depression.

Sensival may be used as part of a combination therapy. This means you may need to take it with other medications.

More common side effects

Some of the more common side effects that can occur with use of Sensival include:

  • low blood pressure
  • high blood pressure
  • confusion (mainly in seniors)
  • sleep problems
  • shakiness
  • dry mouth
  • blurry vision
  • constipation
  • skin rash
  • hives
  • itching
  • skin sensitivity to light
  • nausea
  • vomiting
  • diarrhea
  • stomach cramps
  • decreased sexual desire
  • unexpected weight loss or gain
  • sweating
  • headache

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Some side effects may be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

  • jaw, neck, and back muscle spasms
  • slow or difficult speech
  • shuffling walk
  • uncontrollable shaking of a part of the body
  • fever
  • difficulty breathing or swallowing
  • rash
  • yellowing of the skin or eyes
  • irregular heartbeat

Sensival may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

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