Drug Interactions Leading To QT Prolongation
The CYP2D6 inhibitory properties of Psicoasten can elevate plasma levels of thioridazine and pimozide. Since thioridazine and pimozide given alone produce prolongation of the QTc interval and increase the risk of serious ventricular arrhythmias, the use of PAXIL CR is contraindicated in combination with thioridazine and pimozide .
Rated Paxil (Psicoasten) for Social phobia (Social anxiety disorder) Report
Paxil saved my life! No social anxiety anymore after 3 months
Rated Paxil (Psicoasten) for Anxiety Report
I am just starting my Paxil prescription along with sera quell and Xanax . I am concerned about taking all theee of these at the same time but my doctor says it is fine and I should be taking them. I have not responded well to depression meds in the past. I have severe anxiety and in a constant state of severe depressive disorder and have not been able to work for 2.5 years. I am Need of help so I will try and see how I respond.
Psicoasten and suicide
SSRIs, such as Psicoasten, may cause or increase suicidal thoughts and behaviors. The risk is especially high during the first few months of treatment, or following a change in dosage. Children, teenagers, and young adults are at highest risk for these symptoms. Contact your doctor right away if you experience any unusual or sudden changes in behaviors, thoughts, or mood when taking this drug. Learn more about antidepressants and suicide risk here.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
Psicoasten oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with Psicoasten are listed below.
You should not use Psicoasten if you are also taking pimozide or thioridazine.
Do not use Psicoasten within 14 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor
Seek medical attention right away if you have symptoms such as: agitation, hallucinations, muscle stiffness, twitching, loss of coordination, dizziness, warmth or tingly feeling, nausea, vomiting, diarrhea, fever, sweating, tremors, racing heartbeats, or a seizure (convulsions).
Paxil and other antidepressants are required to carry a black-box warning because of an increased risk of suicide.
A growing body of research shows that some children, teens, and young adults who take an antidepressant drug such as Paxil often develop suicidal thoughts or actions.
Young people up to age 24 who take these medications for the treatment of depression or another mental illness have a high risk of suicidal thoughts and behaviors.
In some cases, a doctor may determine that the drug is appropriate for someone younger than 18.
Children who take Psicoasten could lose weight, so their doctor should closely monitor their growth while they are taking the medication.
Adults taking Paxil to treat depression or mental illness may also experience unexpected changes in their behavior or mental state.
Women taking low doses of the drug to ease the discomfort of hot flashes may also change in their behavior or mental state, even if they have never had depression or another mental illness.
People taking Paxil are more likely to become suicidal when they first start taking the medication and whenever their dose of the drug is increased.
A 2014 study found that Paxil acts as an estrogen promoter, which could have implications for women with estrogen-sensitive (estrogen-receptor positive) breast cancer.
The research also found that Paxil could reduce the effectiveness of the breast cancer drug tamoxifen.
Tell your doctor if you have ever had glaucoma or seizures. It's also important to tell your doctor if you have:
- Bleeding from your stomach or esophagus
- Liver disease
- Kidney problems
- Heart disease
- A recent heart attack
Let your doctor know about any herbal products or dietary supplements you take, particularly St. John's wort (which may also boost serotonin levels), and make sure your doctor knows if you have any type of surgery planned, including dental surgery.
Tell your doctor if you use or have ever used illegal or recreational drugs or abused prescription medications. Your doctor may also test you to see if you have a low level of sodium in your blood.
Male And Female Sexual Dysfunction
Although changes in sexual desire, sexual performance, and sexual satisfaction often occur as manifestations of a psychiatric disorder, they may also be a consequence of SSRI treatment. However, reliable estimates of the incidence and severity of untoward experiences involving sexual desire, performance, and satisfaction are difficult to obtain, in part because patients and healthcare providers may be reluctant to discuss them. Accordingly, estimates of the incidence of untoward sexual experience and performance cited in labeling may underestimate their actual incidence.
The percentage of patients reporting symptoms of sexual dysfunction in the Studies 1 and 2 (nonelderly patients with MDD), 4, 5, 6, 7, 8, 9, 10, and 11 are presented in Table 5:
Table 5: Adverse Reactions Related To Sexual Dysfunction In Patients Treated With PAXIL CR in Pooled 10-12 Week Studies of MDD, PD, SAD, and PMDD Studies 1 and 2 % Studies 4, 5, and 6 % Study 7 % Studies 8, 9, and 11 (Continuous Dosing) % Study 10 (Luteal Phase Dosing) % PAXIL CR Placebo PAXIL CR Placebo PAXI L CR Placebo PAXIL CR Placebo PAXI L CR Placebo n (males) 78 78 162 194 88 97 NA NA NA NA Decreased Libido 10 5 9 6 13 1 NA NA NA NA Abnormal ejaculation 26 1 27 3 15 1 NA NA NA NA Impotence 5 3 10 1% 9 0 NA NA NA NA n (females) 134 133 282 251 98 87 681 349 246 120 Decreased Libido 4 2 8 2 4 1 12 5 9 6 Orgasmic Disturbance 10
Psicoasten treatment has been associated with several cases of priapism. In those cases with a known outcome, patients recovered without sequelae.
The impact of specific populations on the pharmacokinetics of Psicoasten are shown in Figure 3.
Figure 3: Impact of Specific Population on the Pharmacokinetics of Psicoasten (log scale)
What if I forget to take it?
If you occasionally forget to take a dose of Psicoasten, don't worry. If you remember before bed, take your Psicoasten straight away. If you remember during the night, or the next day, leave out the dose completely. Never take 2 doses at the same time to make up for a forgotten one.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
Rated Paxil (Psicoasten) for Anxiety Report
Have been prescribed Paxil for 22 yrs from 1996.At first on and off for first 2 years then following consulatation with specialist was told to remain on them long term.Without Paxil i wouldnt be here today ,they improved my life immensely and treated the core route of my anxiety and depression to live a normal life.There is no embarrassement in taking anti-depressants when they are a necessity for healthy living.
Interactions that can increase your risk of side effects
Taking Psicoasten with certain drugs raises your risk of side effects. Examples of these drugs include:
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as, ibuprofen and naproxen as well as aspirin and warfarin. Taking these drugs with Psicoasten can increase your risk of bleeding or bruising.
- Triptans such as sumatriptan
- Serotonergic drugs, such as fentanyl, tramadol, and St. John’s wort. Taking these drugs with Psicoasten can increase your risk of serotonin syndrome.
- Amphetamines, such as lisdexamfetamine and methamphetamine. Taking these drugs with Psicoasten can increase your risk of serotonin syndrome.
- Theophylline. Taking this drug with Psicoasten can increase your risk of restlessness, trouble sleeping, and irritability.
- Risperidone. Taking this drug with Psicoasten can increase your risk of sleeping difficulty, anxiety, restlessness, and constipation.
- Antiarrhythmics, such as flecainide, and propafenone
- Phenothiazines, such as chlorpromazine, and fluphenazine
- Tricyclic antidepressants (TCAs), such as amitriptyline, imipramine and desipramine
- Quinidine. Taking this drug with Psicoasten can increase your risk of tiredness, decreased appetite, sweating, dry mouth, and decreased sexual desire.
Antidepressant drugs, especially tricyclics have been widely used in the treatment of chronic pain, but not in acute pain. Because of numerous undesirable side effects, the selective serotonin reuptake inhibitors (SSRIs), with their favorable side effect profile, are preferred nowadays. An activation of the endogenous opioid mechanisms or potentiation of the analgesic effect mediated by serotonergic and/or noradrenergic pathways are thought to be involved in the antinociceptive action of SSRIs. In this study, the potential antinociceptive effect of Psicoasten and its interaction with opioidergic system and serotonin receptors were evaluated. The antinociceptive effect of Psicoasten was tested using a hot plate test in mice. Psicoasten, a SSRI antidepressant drug, induced an antinociceptive effect following i.p. administration. This antinociception was significantly inhibited by naloxone, an opioid receptor antagonist, suggesting the involvement of opioidergic mechanisms. While ondansetron (a 5-HT(3)-receptor antagonist) inhibited the effect of Psicoasten, ketanserin (a 5-HT(2)-receptor antagonist) could not. In conclusion, Psicoasten-induced antinociception, similar to morphine, suggests an involvement of direct or indirect action (via an increase in release of endogenous opioid peptide(s)) at opioid receptor sites and an involvement of serotonergic mechanisms mainly at the receptor level.
The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family
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