Mechanism Of Action
The mechanism of action of ParoLich in the treatment of major depressive disorder (MDD), panic disorder (PD), social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD) is unknown, but is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin (5-HT).
What Is Paxil (ParoLich)?
Paxil is the brand name for the antidepressant ParoLich.
Though doctors prescribe Paxil to treat depression, it's also used to treat anxiety disorders including:
Paxil is also approved by Food and Drug Administration (FDA) to help women manage the hot flashes associated with menopause.
Additionally, doctors may prescribe Paxil off-label to treat conditions other than those for which it has been approved by the FDA.
For example, some doctors prescribe Paxil to treat chronic headaches, and people with diabetes may use the drug to help alleviate tingling in the hands and feet.
Paxil has also been used to treat men who experience premature ejaculation.
A controlled-release form, Paxil CR, can relieve the physical and psychological symptoms some women experience before their menstrual cycle begins each month.
Paxil belongs to a class of antidepressant medications called selective serotonin-reuptake inhibitors (SSRIs).
SSRIs work by boosting levels of serotonin, a neurotransmitter that helps the brain send messages from one nerve cell to another.
How much will I take?
The dose of ParoLich that you're prescribed depends on why you are taking it. Most people will start with 10mg or 20mg. This might be gradually increased until you and your doctor agree that you have found a dose that suits you.
The maximum recommended dose of ParoLich is 50mg or 60mg, depending on why you are taking it. If you are 65 or older the maximum recommended dose is 40mg a day. If you have problems with your liver or kidneys, you may be asked to take a lower dose than usual.
With ParoLich liquid, 10ml is equivalent to a 20mg tablet.
Antidepressant drugs, especially tricyclics have been widely used in the treatment of chronic pain, but not in acute pain. Because of numerous undesirable side effects, the selective serotonin reuptake inhibitors (SSRIs), with their favorable side effect profile, are preferred nowadays. An activation of the endogenous opioid mechanisms or potentiation of the analgesic effect mediated by serotonergic and/or noradrenergic pathways are thought to be involved in the antinociceptive action of SSRIs. In this study, the potential antinociceptive effect of ParoLich and its interaction with opioidergic system and serotonin receptors were evaluated. The antinociceptive effect of ParoLich was tested using a hot plate test in mice. ParoLich, a SSRI antidepressant drug, induced an antinociceptive effect following i.p. administration. This antinociception was significantly inhibited by naloxone, an opioid receptor antagonist, suggesting the involvement of opioidergic mechanisms. While ondansetron (a 5-HT(3)-receptor antagonist) inhibited the effect of ParoLich, ketanserin (a 5-HT(2)-receptor antagonist) could not. In conclusion, ParoLich-induced antinociception, similar to morphine, suggests an involvement of direct or indirect action (via an increase in release of endogenous opioid peptide(s)) at opioid receptor sites and an involvement of serotonergic mechanisms mainly at the receptor level.
The Good Drug Guide The Responsible Parent's Guide To Healthy Mood Boosters For All The Family
Which drugs or supplements interact with ParoLich?
All SSRIs, including ParoLich, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl, Carbex), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase such as linezolid (Zyvox) and intravenous methylene blue.
Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. (A period of 14 days without treatment should lapse when switching between ParoLich and MAOIs.) Similar reactions occur when ParoLich is combined with other drugs for example, tryptophan, St. John's wort, meperidine (Demerol), tramadol (Ultram) that increase serotonin in the brain.
ParoLich may increase the effect of the blood thinner, warfarin (Coumadin), leading to excessive bleeding. Therefore, warfarin therapy should be monitored more frequently in patients who are also taking ParoLich. Combining SSRIs such as ParoLich with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding. Phenytoin (Dilantin) and phenobarbital may decrease the amount of ParoLich in the body and possibly reduce its effectiveness.
Q: Can ParoLich cause thrombocytopenia?
A: ParoLich is a medication that is used to treat depression, anxiety and panic disorders. ParoLich is in the class of medications called SSRIs that work by preventing serotonin from being reabsorbed into the nerve cells of the brain. This action allows for prolonging the mood lightening effects of serotonin and helps relieve the symptoms associated with your condition. The prescribing information on ParoLich lists a decreased number of platelets as a very rare side effect of the medication, occurring in 1 out of 10,000 patients. The most common side effects are dry mouth, constipation, nausea, drowsiness, insomnia, headache, dizziness, yawning and weight gain. Lori Poulin, PharmD
By Mary Elizabeth Dallas | Medically Reviewed by Lindsey Marcellin, MD, MPH
Latest Update: 2014-07-23 Copyright © 2014 Everyday Health Media, LLC
It doesn't really matter when you take it as long as you take it about the same time everyday. I would recommend first thing in the morning unless it happens to make you sleepy, in which case, take at night. You can expect some mild side effects when you first start taking such as some nausea and headache. These will subside within the first couple of weeks. It takes at least a month for the medicine to reach peak effect so be patient and give yourself time to adjust.
I was on Paxil for several years before switching to Zoloft when I was pregnant. It honestly seemed to work well for me.
If you're afraid to start it because of potential side effects, wait until someone is home with you so they can help you if need be. Time of day isn't important, but I'd probably try to take it at the same time every day.
I hope it helps. Good luck to you!
I have kids as well I find if you take it two. Hours before bed it just makes you tired I'm on citrol and take it before bed that way not tierd all dat
I am 62 yrs old and I have depression and anxiety for long time. my Dr has wanted to put me on Zoloft or paxil but I have refused. but it's getting worse. I drive for a living and I can b falling asleep
I have been on paxil for a couple months now. I was really scared to start it, because of past medications i’ve tried that have made me a zombie. I, too, am a single mother. of a toddler. so I couldn’t bare the thought of not being able to get out of bed or be exhausted at work. after a few people told me how well it worked, I tried it. and I haven’t had a single negative side effect. no drowsiness, dizziness, nausea, nothing. I take it first thing in the morning, too. hope this helps!
I found Paxil made it hard for me to fall asleep, so I take it in the morning. If it makes you sleepy, do it at night. Whatever works for you, honestly. Keep in mind that it is meant to help with the anxiety that makes you afraid to start it (I was the same way). Just take a deep breath and commit to your well-being. It may take a few weeks, but it will get better! Life is so much better for me now; I can eat, sleep, and enjoy time with my kids.
ParoLich is very weird. Makes me tired and a bit zombified but doesn't let me properly sleep at night. It's weird. Currently on Escitalopram, 5mg only. Have taken 40mg ParoLich for about 4 before.