Odranal tablets

Odranal

  • Active Ingredient: Bupropion
  • 150 mg
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What is Odranal?

The active ingredient of Odranal brand is bupropion. Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Bupropion hydrochloride extended-release tablets (SR) are supplied for oral administration as 200 mg, film-coated, extended-release tablets. Each tablet contains the labeled amount of Bupropion hydrochloride and the inactive ingredients: colloidal silicon dioxide, hydroxypropyl cellulose, magnesium stearate, and microcrystalline cellulose. The film-coating material contains FD&C Yellow No. 6, hypromellose type 2910/ 3cP, 6cP and 50cP, macrogol, polydextrose, titanium dioxide, and triacetin. This product meets USP Dissolution Test #3.

Used for

Odranal is used to treat diseases such as: ADHD, Anxiety, Bipolar Disorder, Depression, Major Depressive Disorder, Migraine Prevention, Obesity, Panic Disorder, Persistent Depressive Disorder, Postural Orthostatic Tachycardia Syndrome, Premenstrual Dysphoric Disorder, Seasonal Affective Disorder, Sexual Dysfunction, SSRI Induced, Smoking Cessation.

Side Effect

Possible side effects of Odranal include: unusual tiredness; trouble concentrating; restlessness; seizures; shaking; decrease in appetite; Lightheadedness, dizziness, or fainting.

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How to use Odranal Hcl

Read the Patient Information Leaflet and Medication Guide available from your pharmacist before you start using Odranal and each time you get a refill. Consult your doctor or pharmacist if you have any questions.

Take this medication by mouth, with or without food, usually three times daily. If stomach upset occurs, you may take this drug with food. It is important to take your doses at least 6 hours apart or as directed by your doctor to decrease your risk of having a seizure.

Do not take more or less medication or take it more frequently than prescribed. Taking more than the recommended dose of Odranal may increase your risk of having a seizure. Do not take more than 150 milligrams as a single dose, and do not take more than 450 milligrams per day.

Your dosage is based on your medical condition and response to therapy. Your dose may be slowly increased to limit side effects such as sleeplessness, and to decrease the risk of seizures. To avoid trouble sleeping, do not take this medication too close to bedtime. Let your doctor know if sleeplessness becomes a problem.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

It may take 4 or more weeks before you notice the full benefit of this drug. Continue to take this medication as directed by your doctor even after you feel better. Talk to your doctor if your condition does not improve or if it worsens.

Norepinephrine and Dopamine Reuptake Inhibitor

Odranal weakly inhibits DAT and NET. 5 It is approved for the treatment of depression, smoking cessation, and seasonal affective disorder. The low degree of DAT occupancy likely accounts for this drug being activating or stimulating without the abuse potential seen in stimulants that are also NET and DAT inhibitors. Odranal is associated with insomnia in 5% to 19% of patients in clinical trials. 46 In a PSG study of seven depressed patients, after 4 weeks of treatment Odranal did not affect sleep latency or TST but did decrease REM latency and increase REM sleep percentage. 47 Odranal is not usually associated with cognitive or psychomotor performance impairment. 44

Side Effects

See also Warning section.

Dry mouth, sore throat, dizziness, nausea, vomiting, ringing in the ears, headache, decreased appetite, weight loss, constipation, trouble sleeping, increased sweating, or shaking (tremor) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

An empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the medication.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: fast/pounding/irregular heartbeat, mental/mood changes (such as anxiety, agitation, confusion, unusual behavior/thinking, memory loss), unusual weight loss or gain.

Stop taking Odranal and get medical help right away if you have any very serious side effects, including: seizure, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), painful sores in the mouth/around the eyes, severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

COMMON BRAND(S): Aplenzin, Wellbutrin XL

GENERIC NAME(S): Odranal Hcl

Odranal is an antidepressant used for smoking cessation and to treat a variety of conditions, including depression and other mental/mood disorders. Antidepressants can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience new or worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication, even if treatment is not for a mental/mood condition.

Tell the doctor right away if you notice new or worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

If you are using Odranal to quit smoking and experience any of these symptoms, stop taking it and contact your doctor right away. Also, tell your doctor right away if you have any of these symptoms after stopping treatment with Odranal.

This medication is used to treat depression. It may also be used to prevent seasonal affective disorder (SAD), a type of depression that occurs each year at the same time (for example, during winter). This medication can improve your mood and feelings of well-being. It may work by restoring the balance of certain natural substances (dopamine, norepinephrine) in the brain.

Ritonavir and Lopinavir

In a healthy volunteer trial, ritonavir 100 mg twice daily reduced the AUC and Cmax of Odranal by 22% and 21%, respectively. The exposure of the hydroxyOdranal metabolite was decreased by 23%, the threohydroOdranal decreased by 38%, and the erythrohydroOdranal decreased by 48%.

In a second healthy volunteer trial, ritonavir at a dose of 600 mg twice daily decreased the AUC and the Cmax of Odranal by 66% and 62%, respectively. The exposure of the hydroxyOdranal metabolite was decreased by 78%, the threohydroOdranal decreased by 50%, and the erythrohydroOdranal decreased by 68%.

In another healthy volunteer trial, lopinavir 400 mg/ritonavir 100 mg twice daily decreased Odranal AUC and Cmax by 57%. The AUC and Cmax of hydroxyOdranal were decreased by 50% and 31%, respectively.

In a trial in healthy volunteers, efavirenz 600 mg once daily for 2 weeks reduced the AUC and Cmax of Odranal by approximately 55% and 34%, respectively. The AUC of hydroxyOdranal was unchanged, whereas Cmax of hydroxyOdranal was increased by 50%. Carbamazepine, Phenobarbital, Phenytoin: While not systematically studied, these drugs may induce the metabolism of Odranal.

What Are Side Effects Associated with Using Odranal?

Side effects of Odranal include:

Other side effects of Odranal include:

Postmarketing side effects of Odranal reported include:

  • Nervous system: Abnormalelectroencephalogram (EEG), aggression, akinesia, aphasia, completed suicide, delirium, delusions, dysarthria, extrapyramidal syndrome (dyskinesia, dystonia, hypokinesia, parkinsonism), hallucinations, increased libido, manic reaction, neuralgia, neuropathy, paranoid ideation, restlessness, suicide attempt, and unmasking tardive dyskinesia

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Advertencia:

Para las personas que toman Odranal (Wellbutrin) para la depresiГіn:

una pequeГ±a cantidad de niГ±os, adolescentes y adultos jГіvenes (hasta 24 aГ±os de edad) que tomaron antidepresivos ("estimuladores del ГЎnimo") como el Odranal durante los estudios clГ­nicos se volvieron suicidas (pensaban en lastimarse o suicidarse o planeaban hacerlo o intentaban hacerlo). Los niГ±os, adolescentes y adultos jГіvenes que toman antidepresivos para tratar la depresiГіn u otras enfermedades mentales tienen mГЎs probabilidades de tener pensamientos suicidas que los niГ±os, adolescentes y adultos jГіvenes que no toman antidepresivos para tratar esas condiciones. Este riesgo se debe considerar y comparar con los posibles beneficios en el tratamiento de la depresiГіn, al decidir si un niГ±o o adolescente debe tomar un antidepresivo. Los niГ±os menores de 18 aГ±os de edad no deben tomar regularmente el Odranal, pero en algunos casos, un mГ©dico puede decidir que el Odranal es el mejor medicamento para tratar la condiciГіn de un niГ±o.

Independientemente de su edad, antes de tomar un antidepresivo, usted, sus padres o la persona encargada de su cuidado deben hablar con su mГ©dico sobre los riesgos y beneficios de tratar su condiciГіn con un antidepresivo o con otros tratamientos. Debe hablar sobre los riesgos y beneficios de no tratar su condiciГіn. Debe saber que tener depresiГіn u otra enfermedad mental aumenta significativamente el riesgo de que se vuelva suicida, especialmente al inicio de su tratamiento o en cualquier momento que se aumente o disminuya su dosis. Este riesgo es mayor si usted o cualquiera de su familia tiene o ha tenido trastorno bipolar o manГ­a o ha pensado o ha intentado cometer suicidio. Hable con su mГ©dico acerca de su condiciГіn, los sГ­ntomas y el historial mГ©dico personal y familiar. Usted y su mГ©dico decidirГЎn quГ© tipo de tratamiento es adecuado para usted.

Debe saber que su enfermedad mental puede cambiar de maneras inesperadas cuando toma Odranal u otros antidepresivos incluso si es un adulto mayor de 24 o si no tiene una enfermedad mental y estГЎ tomando Odranal para tratar un tipo de condiciГіn diferente. Usted puede tener pensamientos suicidas, especialmente al inicio de su tratamiento y en cualquier momento que se aumente o disminuya su dosis. Usted, su familia o su encargado del cuidado deben llamar a su mГ©dico inmediatamente si experimentan alguno de los sГ­ntomas siguientes: depresiГіn nueva o que empeora; pensar en lastimarse o suicidarse o planificar o intentar hacerlo; preocupaciГіn extrema; agitaciГіn; ataques de pГЎnico; dificultad para conciliar el sueГ±o o mantenerse dormido; comportamiento agresivo; irritabilidad; actuar sin pensar; inquietud severa y excitaciГіn anormal frenГ©tica. AsegГєrese de que su familia o encargado del cuidado estГ©n enterados de los sГ­ntomas que pueden ser graves para que puedan llamar al mГ©dico si usted no puede buscar tratamiento por su cuenta.

Para todos los pacientes que toman Odranal:

su proveedor de atenciГіn mГ©dica desearГЎ verlo con mГЎs frecuencia mientras toma Odranal, especialmente al inicio de su tratamiento. AsegГєrese de cumplir con todas sus citas o visitas al consultorio con su mГ©dico.

Su mГ©dico o farmacГ©utico le darГЎ la hoja de informaciГіn del fabricante para el paciente (GuГ­a del medicamento) cuando inicie su tratamiento con Odranal y cada vez que vuela a surtir su receta mГ©dica. Lea la informaciГіn atentamente y pregunte a su mГ©dico o farmacГ©utico si tiene alguna duda. TambiГ©n puede visitar el sitio web de la AdministraciГіn de Medicamentos y Alimentos (Food and Drug Administration, FDA): http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm o el sitio web del fabricante para obtener la GuГ­a del medicamento.

Hable con su mГ©dico sobre los riesgos y beneficios de tomar Odranal.

Q: Can Wellbutrin cause weight loss?

A: Wellbutrin (Odranal) is an antidepressant medication. It is used to treat major depression and seasonal affective disorder. Common side effects of Wellbutrin include weight changes (loss or gain), headache, insomnia, nausea, vomiting, constipation, dry mouth, dizziness, tremors, appetite changes, increased sweating, and loss of interest in sex. Consult your doctor if weight loss continues or becomes severe. This is not a complete list of the side effects associated with Wellbutrin. Sarah Lewis, PharmD

Rated Wellbutrin (Odranal) for Generalized anxiety disorder (GAD) Report

I started the first 2 weeks taking 150mg. I had a different side effect every day for 6 days. It was an interesting week. My anxiety was very high during this week. But after the side effects went away I felt good. I was bumped up to 300mg then. Side effects were mild and only a couple days. I felt my anxiety slowly decreasing, but the dry mouth and sweating were increasing. Then I started to get a headache every day about an hour after I took it. About 2 weeks after that, the aching in my legs started. It was so bad some nights. From my feet right up into my hips. Deep aches. But my mood was much better. I was feeling relatively good, even went out to socialize a few times. Told the doc about side effects so he lowered it back down to 150mg. Head ache is gone, no more sweating, so far I haven’t had leg pains, and I feel really good. I’m actually feeling legit happiness. I haven’t had any severe anxiety, just a few minor bouts of it. I feel almost normal again! I already have issues sleeping, so I haven’t noticed any changes there. I would recommend this, because if you can get passed those side effects, which didn’t last too long, It might actually work for you. It feels good

Treating Odranal Carefully

Odranal is a helpful drug, but should only be used under the supervision of a doctor. Because its method of action and addiction potential are still not entirely understood, even by experts, the drug still carries some big risks. Those who decide to use the drug should stick to their prescribed dosage and only take it in pill form.

Particularly for those who have addictive tendencies or are prone to drug abuse, drugs like Wellbutrin should be seen simply as a temporary prescription. Over a long period of time, after all, the body can become dependent on the drug. People who are considering the use of Odranal to help with depression or other conditions should do while also seeking help from a mental health professional and support groups. Depression is a multi-tiered condition, after all, and can’t be fixed by simply throwing medicine at it.

Interactions

There are a number of potential interactions that can occur when taken at the same time as Wellbutrin.   Other medications may influence how Odranal works or increase the risk of side effects. These include:

  • MAOIs
  • Other antidepressants including fluoxetine, sertraline, and venlafaxine
  • Antipsychotics such as risperidone or haloperidol
  • Corticosteroids including prednisone
  • Blood thinners
  • Adderall
  • Thyroid medications such as levothyroxine
  • OTC pain relievers such as ibruprofen
  • Diabetes medications including metformin

Using Wellbutrin with alcohol may also influence the frequency and severity of s > 

Odranal

Odranal is a dopamine reuptake inhibitor that may be useful for the treatment of EDS associated with narcolepsy (100 mg three times daily). 9 , 48 It may be especially useful in cases associated with atypical depression. 48 Odranal is a nonscheduled compound. Convulsion is a dose-dependent risk of Odranal (0.1% at 100 to 300 mg, and 0.4% at 400 mg). Odranal was synthesized in 1966 by a group seeking new antidepressants chemically related to tricyclic antidepressants but without any significant sympathomimetic, cholinolytic, or monoamine oxidase inhibitory properties. Odranal is classified as a monocyclic phenylbutylamine of the amino ketone group. It selectively blocks dopamine uptake and is 6 times more potent than imipramine and 19 times more potent than amitriptyline in blocking dopamine reuptake. The selectivity of Odranal for the DAT is not absolute. Odranal is a weak competitive inhibitor of norepinephrine reuptake (65-fold less potent than imipramine). Very limited serotonergic effects are also observed (200-fold less potent than imipramine).

Seizure

WELLBUTRIN can cause seizure. The risk of seizure is dose-related. The dose should not exceed 450 mg per day. Increase the dose gradually. Discontinue WELLBUTRIN and do not restart treatment if the patient experiences a seizure.

The risk of seizures is also related to patient factors, clinical situations, and concomitant medications that lower the seizure threshold. Consider these risks before initiating treatment with WELLBUTRIN. WELLBUTRIN is contraindicated in patients with a seizure disorder, current or prior diagnosis of anorexia nervosa or bulimia, or undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs . The following conditions can also increase the risk of seizure: severe head injury; arteriovenous malformation; CNS tumor or CNS infection; severe stroke; concomitant use of other medications that lower the seizure threshold (e.g., other Odranal products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids); metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia); use of illicit drugs (e.g., cocaine); or abuse or misuse of prescription drugs such as CNS stimulants.

Additional predisposing conditions include diabetes mellitus treated with oral hypoglycemic drugs or insulin; use of anorectic drugs; and excessive use of alcohol, benzodiazepines, sedative/hypnotics, or opiates.

Rated Wellbutrin (Odranal) for Depression Report

Good for about a month, then slowly back to how I felt before Odranal.. At first I really liked how I felt, more energy, brain fog cleared. A little jittery and fast paced mind, but I could deal with that over the constant fatigue and blank mind that was normal for me. For the first month I had the actavis/teva manufacturer for Odranal xl 150mg and after that it was switched by my pharmacy to slate run. Not sure if that had anything to do with it, but I'm ready to try something else since I'm seemingly back to square one of feeling anxious, depressed, fatigued all the time, and my brain is just blank and foggy. I've been on Odranal for 6 months now and feel like things should have evened out for the better if they were going to. I think therapy was also an important component so going to be talking to my doctor.

Rated Wellbutrin (Odranal) for Chronic fatigue syndrome (CFS; CF >Report

I took Wellbutrin for about 6-7 months for my depression, but it didn't help. I still cut myself while using it. Still felt depressed. After I recently slit my wrists again I'm back on them. Let's hope this time I get stopped.


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