Mirzalux tablets

Mirzalux

  • Active Ingredient: Mirtazapine
  • 30 mg, 15 mg
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What is Mirzalux?

The active ingredient of Mirzalux brand is mirtazapine. Mirtazapine is an antidepressant. Mirtazapine affects chemicals in the brain that may be unbalanced in people with depression.

Used for

Mirzalux is used to treat diseases such as: Anxiety, Depression, Hot Flashes, Insomnia, Major Depressive Disorder, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder.

Side Effect

Possible side effects of Mirzalux include: sense of constant movement of self or surroundings; convulsions (seizures); menstrual pain; weight gain; mood or mental changes, including anger, feelings of being outside the body, hallucinations (seeing, hearing, or feeling things that are not there), mood swings, and unusual excitement; drowsiness; weakness.

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In an in vivo interaction study in healthy, CYP2D6 extensive metabolizer patients (n=24), Mirzalux (30 mg/day), at steady state, did not cause relevant changes in the pharmacokinetics of steady state paroxetine (40 mg/day), a CYP2D6 inhibitor.

More common side effects

The more common side effects of Mirzalux can include:

  • sleepiness
  • increased appetite
  • weight gain
  • dry mouth
  • constipation
  • dizziness
  • strange dreams

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Rated Mirzalux (Remeron) for Depression Report

Mirzalux saved my life. Something that I find unusual here is the reviews, most warn you from vivid dreams and nightmares - the pills had the total opposite effect on me.. I have been struggling with vivid dreams and sleep paralysis since I was a kid, they often caused me lack of sleep because of the frightening experienxe. However when i started on Mirzalux I haven’t had a single vivid dream or experience of sleep paralysis! 15 mg 1 hr before sleep and I will sleep like a baby the whole night. The only side effect I had is the hunger and cravings but that was just a bonus for me as I was already underweight so I needed to take on a few kgs anyway.

Rated Mirzalux (Remeron) for Depression Report

I started Mirzalux about a year ago, due to my trouble sleeping and overall social anxiety. I had a thing where I couldn't eat in front of people, without feeling extremely sick and wanting to vomit. It worked for a while, but wore off after the first four months, up my dosage and it worked again, but then went away the same way. I wasn't eating enough then, and I started eating a lot more after it. Recently, I finally started getting very self-conscious about my weight, something I've never really had a problem before, but I gained almost 25 pounds or more. I tried changing up my lifestyle, eating healthy, working out, but I can't shake this weight off and I'm still depressed. I didn't connect the dots before it was too late, I'm talking to my doctor about slowly getting off so I can get my body back. I just started a new anti-depressant anyways with this one, so hopefully, we can find something to help me sleep better. Not saying it's a bad medication, but it's not for everyone. I just wish I had gotten around to realizing it's symtoms sooner.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history or family history of psychiatric disorders (e.g., bipolar/manic-depressive disorder), history or family history of suicide attempts, liver disease, kidney disease, seizures, high blood cholesterol or triglyceride levels, heart disease (e.g., recent heart attack, angina), stroke, severe loss of body fluids (dehydration), low blood pressure, personal or family history of glaucoma (angle-closure type).

Mirzalux may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Mirzalux, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Mirzalux safely.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition where you must restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist regarding the safe use of this medicine.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and QT prolongation (see above).

This medication should be used only when clearly needed during pregnancy. If this medication is used during the last 3 months of pregnancy, infrequently your newborn may develop symptoms including feeding or breathing difficulties, seizures, muscle stiffness, jitteriness or constant crying. Report any such symptoms to your doctor promptly. However, since untreated mental/mood disorders (such as depression) can be a serious condition, do not stop taking this medication unless your doctor directs you to do so. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk. Consult your doctor before breast-feeding.

How should this medicine be used?

Mirzalux comes as a tablet and as a disintegrating tablet to take by mouth. It usually is taken once a day at bedtime. It may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Mirzalux exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

To take a Mirzalux disintegrating tablet, open the blister pack with dry hands and place the tablet on your tongue. The tablet will disintegrate on the tongue and can be swallowed with saliva. No water is needed to swallow disintegrating tablets. Once the tablet is removed from the blister pack, it cannot be stored. Do not split Mirzalux disintegrating tablets.

It may take several weeks or longer for you to feel the full benefit of Mirzalux. Continue to take Mirzalux even if you feel well. Do not stop taking Mirzalux without talking to your doctor. Your doctor probably will decrease your dose gradually.

Rated Mirzalux (Remeron) for Depression Report

Feeling better as far as the anxiety and suicidal thoughts are concerned. However It hasn't helped me sleep better and the weight has piled on, I'm constantly hungry

Related Questions & Answers

Query: Hello doctor, I was taking 30 mg Mirzalux for 10 weeks before being told by the doctor to take 45 mg three weeks ago. I have now been told to drop it back to 30 mg a day. I also have been taking Xanor 0.25 mg for past six months. For the first two weeks, I took two tablets a day then was told to. Read Full »

Query: Hi doctor, My mother is 52 years old and suffering from headache since so many years. We started the psychiatric treatment for her before six years. She has to take all medicines every day and whenever she misses them, she suffers from the headache. So, we decided to go for her brain MRI and the res. Read Full »

Query: Hi doctor, Which atypical antipsychotic will cause the least weight gain? Abilify is not an option as I am allergic to it. Also, Geodon or Zeldox gave me severe drowsiness to the point that I had to sleep or could not open my eyes. Please help me. Read Full »

Major Depression

The only indication for Mirzalux (Remeron) is the treatment of major depressive disorder.

According to the FDA label, the efficacy of Mirzalux tablets as a treatment for major depressive disorder was established in four placebo-controlled, 6-week trials in adult outpatients meeting DSM-III criteria for major depressive disorder .

In eight trials (randomized controlled trials) of major depression, improvement began in the first week of treatment and was greater than placebo and equal to that of the tricyclic antidepressant (TCA) amitriptyline .

Mirzalux is also as effective as trazodone in short-term randomized controlled trials of patients with moderate or severe depression, including elderly patients that also had anxiety or sleep disturbance .

Mirzalux was more effective than SSRIs and the serotonin-noradrenaline reuptake inhibitor (SNRI) venlafaxine after two weeks and short-term therapy for major depression .

However, in terms of long-term efficacy, it was equally as effective as TCAs and SSRIs in treating major depression .

Mirzalux combined with other antidepressants improves efficacy in the treatment of depression and, in conjunction with SNRIs, has successfully used to treat treatment-resistant major depression .

Mirzalux is hypothesized to reduce depression by:

  • Blocking α2-adrenoceptors, which lead to enhanced release of norepinephrine .
  • Potent blocking of serotonin 5-HT2 and 5-HT3, which decreases inhibition of serotonin-releasing neurons, increasing overall serotonergic signaling .
  • Blocking the histamine H1 receptors, causing a sedative effect, and improvement of sleep .
  • Activating mu- and kappa 3-opio >Other Potential Uses

Before taking this medicine

You should not take this medicine if you are allergic to Mirzalux.

Do not use Mirzalux if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure Mirzalux is safe for you, tell your doctor if you have ever had:

liver or kidney disease;

long QT syndrome (in you or a family member); or

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with Mirzalux and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

The orally disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Low Appetite/Anorexia Nervosa Associated with Depression

Mirzalux may have an appetite-stimulating effect in patients taking it. Weight gain and increased appetite are among the most commonly reported side effects of the medication .

The appetite-stimulating effects of Mirzalux and antidepressant effects of the medication show it as a promising drug in the use of patients that have anorexia caused by depression, or depression caused by anorexia .

Potential mechanisms of Mirzalux-induced weight gain:

  • Blocking 5HT2C and H1 receptors .
  • Mirzalux possibly reduces the energy your body expands, which results in weight gain .

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Suic > Hives can be seen in allergic reactions to Mirzalux.
  • rash, itchy welts (hives), or blisters, alone or with fever or joint pain
  • Increased appetite or weight
  • High cholesterol and triglyceride levels
  • muscle aches and pains
  • kidney problems
  • Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Mirzalux oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

    To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

    Examples of drugs that can cause interactions with Mirzalux are listed below.

    Mixing Mirzalux with herbal remedies and supplements

    Do not take St John's wort while you are being treated with Mirzalux as this will increase your risk of side effects.

    Sleepiness or dizziness

    Mirzalux can cause sleepiness or dizziness. For this reason, a person should avoid using heavy equipment or driving after taking Mirzalux.

    The risk of QT prolongation and/or ventricular arrhythmias (e.g., Torsades de Pointes) may be increased with concomitant use of medicines which prolong the QTc interval (e.g., some antipsychotics and antibiotics) and in case of Mirzalux overdose (see ADVERSE REACTIONS and OVERDOSE sections).


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