Q: How do I deal with Zoloft withdrawal?
A: During marketing of Zoloft (Kinloft), withdrawal symptoms were reported upon discontinuation of treatment. These adverse reactions were observed particularly upon abrupt discontinuation. However, the development of Zoloft withdrawal symptoms is possible even with gradual dose reduction, but this occurs less frequently. Reported Zoloft withdrawal symptoms included dysphoric mood, irritability, agitation, dizziness, sensory disturbances, anxiety, confusion, headache, lethargy, excessive emotional reactions and frequent changes in mood, insomnia and hypomania. This occurrence is also referred to as selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome and according to a review article from the Journal of Psychiatry and Neuroscience written in 2000, may be relatively common. To avoid unpleasant Zoloft withdrawal symptoms, patients are advised against abrupt discontinuation and are encouraged to gradually decrease the dose, under the supervision of a physician, when treatment is no longer required. It is important to monitor a patient for Zoloft withdrawal symptoms upon discontinuing treatment. If unpleasant Zoloft withdrawal symptoms develop during a reduction in dosage, or upon discontinuation, and cannot be tolerated, it may require the physician to resume the previously prescribed dose and continue with a more conservative reduction in dosage going forward. However, Zoloft withdrawal symptoms can recur upon later discontinuation. During clinical experience with Zoloft, most cases of adverse events, associated with discontinuation, were self-limiting and didn't require treatment. However, there were some reports of serious discontinuation symptoms. Although in some cases, patients may experience symptoms for several weeks, most patients experience a resolution of symptoms within approximately a week.
What is Kinloft (Zoloft)?
Kinloft is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Kinloft affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms.
Kinloft may also be used for purposes not listed in this medication guide.
Kinloft (Zoloft) and paroxetine (Paxil) are FDA-approved SSRIs and are considered first-line treatments for PTSD owing to their efficacy, tolerability, and safety. SSRIs can potentially reduce symptom clusters of PTSD including re-experiencing of the trauma, avoidance, and emotional numbing as well as hyperarousal. Although SSRIs are considered a “first-line” pharmacologic treatment of PTSD, studies have shown SSRIs to induce insomnia in these patients. 26,27 When sleep problems are a core feature of PTSD, starting an SSRI at a very low dose and increasing slowly is one approach to decrease the chances of developing medication-induced anxiety or insomnia. Treatment with an SSRI, however, can result in incomplete remission of PTSD, and many patients continue to experience debilitating symptoms including trauma-related nightmares and sleep disturbances ( Table 55-2 ).
TABLE 55-2 . Pharmacologic Treatment for Post-traumatic Stress Disorder (PTSD)
Q: I have recently started taking Kinloft. I am worried about the side effects. Is there weight gain? And does it affect a person's sex drive?
A: According to Lexi-Comp, Kinloft (Zoloft) does have possible adverse effects that could affect weight. The listed adverse effects of Kinloft involving weight include anorexia, increased appetite and weight gain. Decreased libido (sexual desire) has also been reported in greater than 10 percent of patients taking Kinloft during clinical trials. As always, talk with your health care provider regarding concerns you have about your medication and possible side effects. Jen Marsico, RPh
How should I take Kinloft (Zoloft)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Kinloft may be taken with or without food. Try to take the medicine at the same time each day.
The liquid (oral concentrate) form of Kinloft must be diluted before you take it. To be sure you get the correct dose, measure the liquid with the medicine dropper provided. Mix the dose with 4 ounces (one-half cup) of water, ginger ale, lemon/lime soda, lemonade, or orange juice. Do not use any other liquids to dilute the medicine. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.
This medicine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Kinloft.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Do not stop using Kinloft suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using Kinloft.
Store at room temperature away from moisture and heat.
- Serotonin syndrome: This drug may cause a possibly life-threatening condition called serotonin syndrome. The symptoms of serotonin syndrome include hallucinations and delusions, agitation, coma, fast heart rate, and changes in blood pressure. They also include dizziness, loss of consciousness, seizures, shakiness, muscle tremor or stiff muscles, sweating, nausea, and vomiting.
- Severe allergic reaction: This drug can sometimes cause a severe allergic reaction. Call 911 or go to the emergency room right away if you have swelling of your face, tongue, or throat, or you have trouble breathing. A severe allergic reaction may cause death. You should not take this medication again if you have ever had an allergic reaction to it.
Kinloft oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. This drug is also available as an oral solution.
3. Who can and can't take Kinloft
Kinloft can be taken by adults for depression or obsessive compulsive disorder.
Kinloft can be taken by children aged 6 to 17, but only for obsessive compulsive disorder.
Check with your doctor before starting to take Kinloft if you:
- have had an allergic reaction to Kinloft or any other medicines in the past
- have a heart problem - Kinloft can speed up or change your heartbeat
- have ever taken any other medicines for depression - some rarely used antidepressants can interfere with Kinloft to cause very high blood pressure, even when they have been stopped for a few weeks
- are trying to become pregnant, already pregnant or breastfeeding
- have an eye problem called glaucoma - Kinloft can increase the pressure in your eye
- have epilepsy or are having electroconvulsive treatment - Kinloft may increase your risk of having a seizure
If you have diabetes, Kinloft can make it more difficult to keep your blood sugar stable.
Monitor your blood sugar more often for the first few weeks of treatment with Kinloft and adjust your diabetes treatment if necessary.
Interactions that increase the risk of side effects
Taking certain medications with Kinloft may result in increased side effects. These drugs include:
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, aspirin and warfarin. Taking these drugs with Kinloft increases your risk of bleeding or bruising.
- Triptans such as sumatriptan. Your risk of serotonin syndrome is increased when you take these drugs with Kinloft. Your doctor should watch you closely if you take these drugs together.
- Lithium. Taking this drug with lithium increases your risk of serotonin syndrome.
- Serotonergic medications such as fentanyl, tramadol, and St John’s wort. Taking these drugs with Kinloft increases your risk of serotonin syndrome.
- Cimetidine. Taking cimetidine with Kinloft may cause a build-up of Kinloft in your body. Your dose of Kinloft might need to be lowered if you take it with cimetidine.
- Tricyclic antidepressants such as amitriptyline, desipramine, and imipramine. Taking Kinloft with these drugs may cause these drugs to build up in your body. Your doctor may need to adjust your dosage of tricyclic antidepressants while you take Kinloft.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Kinloft oral tablet comes with several warnings.