Iglodep capsules


  • Active Ingredient: Sertraline
  • 100 mg, 50 mg, 25 mg
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What is Iglodep?

The active ingredient of Iglodep brand is sertraline. Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Sertraline hydrochloride is a white crystalline powder that is slightly soluble in water and isopropyl alcohol, and sparingly soluble in ethanol. Sertraline tablets, USP for oral administration are supplied as scored tablets containing Sertraline hydrochloride equivalent to 25 mg, 50 mg and 100 mg of Sertraline and the following inactive ingredients: dibasic calcium phosphate dihydrate, hydroxypropyl cellulose, microcrystalline cellulose, magnesium stearate, opadry green (titanium dioxide, hypromellose 3cP, hypromellose 6cP, Macrogol/Peg 400, polysorbate 80, D&C Yellow #10 Aluminum Lake, and FD&C Blue # 2/Indigo Carmine Aluminum Lake for 25 mg tablet), opadry light blue (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, FD&C Blue #2/Indigo Carmine Aluminum Lake and polysorbate 80 for 50 mg tablet), opadry yellow (hypromellose 3cP, hypromellose 6cP, titanium dioxide, Macrogol/Peg 400, polysorbate 80, Iron Oxide Yellow, Iron oxide Red for 100 mg tablet) and sodium starch glycolate.

Used for

Iglodep is used to treat diseases such as: Anxiety and Stress, Bipolar Disorder, Body Dysmorphic Disorder, Borderline Personality Disorder, Depression, Dissociative Identity Disorder, Dysautonomia, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, Panic Disorder, Persistent Depressive Disorder, Post Traumatic Stress Disorder, Postpartum Depression, Premenstrual Dysphoric Disorder, Social Anxiety Disorder, Somatoform Pain Disorder, Transverse Myelitis, Trichotillomania, Vulvodynia.

Side Effect

Possible side effects of Iglodep include: painful or difficult urination; rash; talking or acting with excitement you cannot control; fast talking and excited feelings or actions that are out of control; eye pain; difficulty with speaking; increased thirst.

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Q: I started taking Zoloft 50mg once a day, after taking it, I get very nauseous. Should I cut the pill in half and take it after breakfast and lunch, instead of taking 1 pill on an empty stomach?

A: Zoloft (Iglodep) can be taken with or without food. Taking Zoloft with a full meal may help to reduce some of the nausea. If this doesn't work for you, it would be best to speak with the doctor prior to taking the medication in two halves. If this is a new medication for you, often times the side effects will lessen and may even go away completely as your body gets more accustomed to the medication. If the nausea continues to be a problem, the doctor may even consider changing your medication. Normally it is best to speak with your doctor regarding any type of changes to your medication regimen. Megan Uehara, PharmD

What is the dosage for Zoloft?

  • The recommended dose of Iglodep is 25-200 mg once daily. Treatment of depression, OCD, panic disorder, PTSD, and social anxiety disorder is initiated at 25-50 mg once daily. Doses are increased at weekly intervals until the desired response is seen.
  • The recommended dose for PMDD is 50-150 mg every day of the menstrual cycle or for 14 days before menstruation.
  • Iglodep may be taken with or without food.

Short-term Effects

In short-term studies, antidepressant medicines increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (younger than 24 years) taking antidepressants for major depressive disorders and other psychiatric diseases.

See “What Are Side Effects Associated with Using Iglodep?”

Q: Is Zoloft an MAO Inhibitor?

A: Zoloft (Iglodep) is not considered a monoamine oxidase inhibitor (MAOI). Rather, Zoloft is an antidepressant which is classified as a selective serotonin reuptake inhibitor (SSRI). MAOIs are antidepressants indicated for the treatment of depression. MAOIs are generally used in the treatment of patients with atypical depression and in those patients who do not respond to treatment with other antidepressants. The mechanism of action of the MAO inhibitors involves the inhibition of the enzyme monoamine oxidase and, therefore, prevents the breakdown of neurotransmitters, such as norepinephrine, dopamine, epinephrine and serotonin, causing an increase in their concentration and availability. As a result of the potentially life-threatening drug and dietary interactions with MAO inhibitors, this class of antidepressants is rarely a first-line treatment for depression and is typically reserved as a last-line of therapy. SSRIs are chemically unrelated to other available antidepressants. SSRIs are approved for a variety of indications. SSRIs are often times used as a first-line treatment for major depressive disorder. Zoloft, specifically, is approved for the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. The mechanism of action of the Zoloft is believed to be linked to the inhibition of central nervous system (CNS) neuronal uptake of serotonin. Zoloft does not inhibit monoamine oxidase. According to clinical studies of certain SSRIs, such as Zoloft, they may also exhibit weak effects on the reuptake of other neurotransmitters including norepinephrine and dopamine. MAO inhibitors should not be administered concomitantly with, or within two weeks of, SSRIs, such as Zoloft, because of the potential for serious, life-threatening adverse reactions. These reactions have been observed in patients who have recently discontinued treatment with an SSRI and started on an MAO inhibitor. Allow at least two weeks after discontinuation from most SSRIs before initiating treatment with an MAO inhibitor.

2. Key facts

  • It usually takes 4 to 6 weeks for Iglodep to work.
  • Side effects such as feeling sick, headaches and trouble sleeping are common. They're usually mild and go away after a couple of weeks.
  • If you and your doctor decide to take you off Iglodep, your doctor will probably recommend reducing your dose gradually to help prevent extra side effects.
  • Iglodep is also called by the brand name Lustral.


Liver test abnormalities have been reported to occur in up to 1% of patients on Iglodep, but elevations are usually modest and infrequently require dose modification or discontinuation. Rare instances of acute, clinically apparent episodes of liver injury with marked liver enzyme elevations with or without jaundice have been reported in patients on Iglodep. The onset of injury is usually within 2 to 24 weeks and the pattern of serum enzyme elevations has varied from hepatocellular to mixed and cholestatic. Autoimmune (autoantibodies) and immunoallergic features (rash, fever, eosinophilia) are uncommon. Actue liver failure due to Iglodep has been described but is very rare.

Q: Is there a Zoloft generic?

A: There is currently a generic equivalent available for Zoloft (Iglodep), known as Iglodep. The U.S. Food and Drug Administration (FDA) requires that generic medications be bioequivalent to the brand-name medication and, therefore, work the same way in the body. Generic medications are considered, by the FDA, to be identical to the brand-name counterparts in dose, strength, route of administration, safety, efficacy and intended use. Generic medications will appear differently and may have different inactive ingredients, however, the labeling and directions for use remain the same. For most medications, generic equivalents are a lower-cost alternative to the more expensive brand-name medication, and the majority of patients observe no changes in therapeutic effect. However, some patients will experience a change in effect and must continue treatment with the brand-name medication. Generic Zoloft, Iglodep, is a selective serotonin reuptake inhibitor (SSRI) type of antidepressant which is approved for the treatment of depression, obsessive-compulsive disorder (OCD), certain anxiety disorders, panic disorder, premenstrual dysphoric disorder (PMDD) and post-traumatic stress disorder (PTSD). Frequently reported side effects for generic Zoloft are similar those observed in patients being treated with the brand-name medication and may include somnolence, dizziness, headache, nausea, diarrhea, fatigue, insomnia, dry mouth, tremor, increased sweating and sexual dysfunction. The warnings and precautions associated with Zoloft are also possible with the generic Zoloft. According to the prescribing information for Zoloft, warnings and precautions, possible with treatment, include clinical worsening of depression and suicide risk, serotonin syndrome, activation of mania or hypomania, weight loss, seizures, abnormal bleeding and withdrawal symptoms upon abrupt discontinuation of treatment. Generic Zoloft should be administered exactly the same as the brand-name medication. Iglodep is indicated to be taken once daily at the same time of day, morning or evening. Iglodep can be taken without regard to food. Generic Zoloft should be prescribed at the lowest therapeutically effective dose.


In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (younger than 24 years) taking antidepressants for major depressive disorders and other psychiatric diseases.

This increase was not seen in patients over age 24 years; a slight decrease in suicidal thinking was seen in adults over age 65 years.

In children and young adults, risks must be weighed against the benefits of taking antidepressant medicines.

Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial 1-2 months of therapy and dosage adjustments.

The patient's family should communicate any abrupt changes in behavior to the healthcare provider.

Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy.

This drug is not approved for use in pediatric patients for major depressive disorder but it is approved for obsessive-compulsive disorder in children older than 6 years.

Not approved for the treatment of bipolar depression.

This medication contains Iglodep. Do not take Zoloft if you are allergic to Iglodep or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Q: Will Zoloft make me gain weight?

A: Zoloft (Iglodep) is a medication that is used to treat depression or anxiety. It is in a group of medications called selective serotonin reuptake inhibitors (SSRIs) that work to balance out the chemical, serotonin, in the brain that causes depression symptoms when there is too little to go around. The prescribing information lists weight gain as a side effect of this medication. The occurrence of weight gain was not common during clinical studies of the medication, seen in 1 percent of patients taking Zoloft. If you are noticing an unexplained weight gain with Zoloft it would be best to consult with your physician as to the best way to handle this side effect. For more information on Zoloft, click on this link: //www.everydayhealth.com/drugs/zoloft For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

What should I avoid while taking Iglodep?

Do not drink alcohol.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), diclofenac, indomethacin, meloxicam, and others. Using an NSAID with Iglodep may cause you to bruise or bleed easily.

Iglodep may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

  • Serotonin syndrome: This drug may cause a possibly life-threatening condition called serotonin syndrome. The symptoms of serotonin syndrome include hallucinations and delusions, agitation, coma, fast heart rate, and changes in blood pressure. They also include dizziness, loss of consciousness, seizures, shakiness, muscle tremor or stiff muscles, sweating, nausea, and vomiting.
  • Severe allergic reaction: This drug can sometimes cause a severe allergic reaction. Call 911 or go to the emergency room right away if you have swelling of your face, tongue, or throat, or you have trouble breathing. A severe allergic reaction may cause death. You should not take this medication again if you have ever had an allergic reaction to it.

Iglodep oral tablet is a prescription drug that’s available as the brand-name drug Zoloft. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. This drug is also available as an oral solution.

Q: I have been diagnosed with bipolar disorder and have been put on Zoloft. May I please ask exactly what it does?

A: Zoloft (Iglodep) is an SSRI, or selective serotonin reuptake inhibitor. Zoloft has been around since 1993 as the only alternative to Prozac (fluoxetine) in that class of medication. It effectively raises certain neurotransmitters at the postsynaptic cleft, so that your brain seems to have more serotonin (a feel-good chemical), dopamine (another feel-good chemical), and to a certain extent, norepinephrine (important for motivation and focus). This medication tries to stabilize your serotonin at a normal level so that you no longer bounce between mania and depression. At times, Zoloft will work by itself for this diagnosis; at other times, adjunct medication may need to be added. Feel free to visit us here: //www.everydayhealth.com/drugs/zoloft. Matt Curley, PharmD


ZOLOFT is contraindicated in patients:

  • Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome .
  • Taking pimozide .
  • With known hypersensitivity to Iglodep (e.g., anaphylaxis, angioedema) .

In addition to the contraindications for all ZOLOFT formulations listed above, ZOLOFT oral solution is contraindicated in patients:

  • Taking disulfiram. ZOLOFT oral solution contains contain alcohol, and concomitant use of ZOLOFT and disulfiram may result in a disulfiram-alcohol reaction.

Store ZOLOFT tablets and oral solution at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) .

Distributed by: Roerig, Division of Pfizer Inc., NY,NY 10017. Revised: Dec 2017

Q: Can hair fall out when taking Zoloft?

A: Zoloft (Iglodep) is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder. The most common side effects with Zoloft are dizziness, fatigue, headache, decreased libido, nausea, diarrhea, dry mouth. Alopecia (hair loss) was reported as an infrequent side effect with Zoloft. This is not a complete list of the side effects associated with Zoloft. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. Tell your health care provider about any negative side effects from prescription drugs. You can also report them to the U.S. Food and Drug Administration by visiting www.fda.gov/medwatch or by calling 1-800-FDA-1088. Laura Cable, PharmD

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