What other information should I know?
Keep all appointments with your doctor.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking Depreger.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Is Zoloft safe to use during pregnancy or while breastfeeding?
- Use of Depreger during the 3rd trimester of pregnancy may lead to adverse effects in the newborn.
- Use of Depreger by nursing mothers has not been adequately evaluated.
What if I take too much?
The amount of Depreger that can lead to an overdose varies from person to person.
Renal impairment: Dose adjustment not necessary
- Mild (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50%
- Moderate-to-severe (Child-Pugh 7-15): Not recommended; Depreger is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied
The elderly are prone to SSRI/SNRI-induced hyponatremia; monitor closely
Q: Is Zoloft an MAO Inhibitor?
A: Zoloft (Depreger) is not considered a monoamine oxidase inhibitor (MAOI). Rather, Zoloft is an antidepressant which is classified as a selective serotonin reuptake inhibitor (SSRI). MAOIs are antidepressants indicated for the treatment of depression. MAOIs are generally used in the treatment of patients with atypical depression and in those patients who do not respond to treatment with other antidepressants. The mechanism of action of the MAO inhibitors involves the inhibition of the enzyme monoamine oxidase and, therefore, prevents the breakdown of neurotransmitters, such as norepinephrine, dopamine, epinephrine and serotonin, causing an increase in their concentration and availability. As a result of the potentially life-threatening drug and dietary interactions with MAO inhibitors, this class of antidepressants is rarely a first-line treatment for depression and is typically reserved as a last-line of therapy. SSRIs are chemically unrelated to other available antidepressants. SSRIs are approved for a variety of indications. SSRIs are often times used as a first-line treatment for major depressive disorder. Zoloft, specifically, is approved for the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD) and social anxiety disorder. The mechanism of action of the Zoloft is believed to be linked to the inhibition of central nervous system (CNS) neuronal uptake of serotonin. Zoloft does not inhibit monoamine oxidase. According to clinical studies of certain SSRIs, such as Zoloft, they may also exhibit weak effects on the reuptake of other neurotransmitters including norepinephrine and dopamine. MAO inhibitors should not be administered concomitantly with, or within two weeks of, SSRIs, such as Zoloft, because of the potential for serious, life-threatening adverse reactions. These reactions have been observed in patients who have recently discontinued treatment with an SSRI and started on an MAO inhibitor. Allow at least two weeks after discontinuation from most SSRIs before initiating treatment with an MAO inhibitor.
Depreger is a selective serotonin reuptake inhibitor (SSRI) used in the therapy of depression, anxiety disorders and obsessive-compulsive disorder. Depreger therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.
Q: How can I lose weight on Zoloft?
A: During controlled clinical trials of Zoloft (Depreger), patients experienced a minimal one or two pound weight loss, on average. Patients did not report significant weight gain or difficulty losing weight during clinical studies or postmarketing experience with Zoloft. However, Zoloft has been reported to cause changes in appetite and weight. Zoloft is antidepressant that affects certain neurotransmitters in the brain, specifically serotonin. Zoloft is a potent and selective inhibitor of neuronal serotonin reuptake in the central nervous system and therefore categorized as a selective serotonin reuptake inhibitor (SSRI). Zoloft is used for the treatment of post-traumatic stress disorder (PTSD), panic disorder, premenstrual dysphoric disorder (PMDD), anxiety disorders, obsessive-compulsive disorder (OCD) and major depressive disorder. In general, irrespective of drug therapy, the safest and most effective method for long-term weight loss is proper diet and exercise. Eating a healthy, well-balanced diet full of fruits, vegetables and whole grains while limiting sugar, processed foods and alcohol typically people lose weight. According to the prescribing information, patients being treated with Zoloft are already cautioned to avoid alcohol. Although studies did not show an increase in mental or motor skill impairment with alcohol, patients taking Zoloft are still advised to avoid alcohol. According to the National Heart Lung and Blood Institute (NHLBI), a part of the National Institutes of Health (NIH), to lose weight it is essential for individuals to make lifestyle changes which focus on reducing calories from food and drink, a healthy eating plan and proper portion control. Furthermore, the NHLBI outlines a healthy eating plan to control portion sizes and include fruits, vegetables, whole grains and fat-free or low-fat dairy products. A healthy eating plan should also include lean meats, poultry, fish, beans, eggs and nuts and be low in saturated fat, trans fat, cholesterol, sodium and added sugars. To safely and effectively lose weight, in general and while taking Zoloft, individuals need to expend more calories than they take in. Essentially, reduce the daily caloric intake from food and beverages and increase calories burned through physical exercise. An appropriate diet and exercise regimen should initially be under the guidance of a physician.